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Deciphering the role of mitochondrial/autophagy dysfunction in regulating inflammatory processes during AMD pathogenesis

Award Number: R00EY033421
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2026
PERIOD OF PERFORMANCE END DATE: 05/31/2029

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Deciphering the role of mitochondrial/autophagy dysfunction in regulating inflammatory processes during AMD pathogenesis - The deregulation of autophagy and heightened inflammation has been implicated in dry age-related macular degeneration (AMD), the leading cause of blindness in elderly globally. This proposal will use a novel mouse model and human iPSC-derived RPE cells from controls and AMD risk allele containing donors to decipher a yet unknown role of the crosstalk between the organelle homeostasis/autophagy and inflammatory processes in the pathogenesis of dry AMD. We envisage that the proposed studies will help to develop strategies, potentially leading to novel therapies for this disease, which has no treatment available at the moment.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $248,737 )
2026	2026	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	35 STATE ST	ALBANY	NY	12207	ALBANY	USA	Vision Research	000	3	6/5/2026	EXTENSION WITH OR WITHOUT FUNDS	$248,737
														Subtotal = $248,737

Grand Total All Awards = $248,737

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Deciphering the role of mitochondrial/autophagy dysfunction in regulating inflammatory processes during AMD pathogenesis

Award Number: R00EY033421

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2026

PERIOD OF PERFORMANCE END DATE: 05/31/2029

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