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Mechanisms of Visual Encoding and Plasticity in Anterior Cingulate Cortex

Award Number: R00EY028964
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2018
PERIOD OF PERFORMANCE END DATE: 06/30/2024

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Mechanisms of Visual Encoding and Plasticity in Anterior Cingulate Cortex - PROJECT SUMMARY/ABSTRACT Mouse primary visual cortex (V1) is capable of encoding visual stimuli and undergoing bidirectional plasticity coincident with patterned visual experience. The prefrontal anterior cingulate cortex (ACC) receives input from visual cortex, but mechanisms of visual encoding and experience-dependent plasticity in ACC are not well- understood. The goal of the proposed research is to define how ACC encodes and adapts to patterned visual experience. During the K99 phase, I will pair in vivo and ex vivo recordings with optogenetic and chemogenetic circuit manipulations to study how ACC microcircuits encode visual input. K99 training in two-photon calcium imaging will enable longitudinal studies of how individual neurons adapt to visual experience during the R00 phase. As abnormal sensory processing is a common feature of autism spectrum disorder, further R00 research will use approaches developed during K99 training to assess ACC microcircuit function in single-gene mouse models of autism. My long-term career goals are to advance basic knowledge of visual processing and to improve the lives of individuals with neurodevelopmental disorders through a collaborative program of basic and translational research. To achieve my goal of securing a tenure track faculty position as an independent researcher in neuroscience research, I have developed a comprehensive career development plan with the support of co-mentors Dr. Ben Philpot and Dr. Spencer Smith (UNC) and collaborators Dr. Paul Manis (UNC) and Dr. Jeff Gavornik (Boston University). This plan includes a) technical training in two-photon imaging, b) collaborative projects, c) training in presentation skills, d) training in mentoring skills, e) training in grant writing, f) career guidance, g) clinical exposure, h) formal coursework, i) teaching opportunties, and j) progress monitoring and evalulation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2022	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Vision Research	000	5	3/18/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $345,669 )
2022	2022	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Vision Research	002	5	9/20/2022	NON-COMPETING CONTINUATION	$7,169
2022	2022	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Vision Research	001	5	7/7/2022	SUPPLEMENT FOR EXPANSION	$106,688
2022	2022	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Vision Research	000	5	6/16/2022	NON-COMPETING CONTINUATION	$231,812
														Subtotal = $345,669

Issue Date FY: 2021 ( Subtotal = $236,357 )
2021	2021	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Vision Research	000	4	6/10/2021	NON-COMPETING CONTINUATION	$236,357
														Subtotal = $236,357

Issue Date FY: 2020 ( Subtotal = $276,493 )
2020	2020	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Vision Research	001	3	9/30/2020	EXTENSION WITH OR WITHOUT FUNDS	$27,493
2020	2020	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Vision Research	000	3	6/10/2020	EXTENSION WITH OR WITHOUT FUNDS	$249,000
														Subtotal = $276,493

Grand Total All Awards = $858,519

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Mechanisms of Visual Encoding and Plasticity in Anterior Cingulate Cortex

Award Number: R00EY028964

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2018

PERIOD OF PERFORMANCE END DATE: 06/30/2024

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