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Perceptual stability during torsional eye movements

Award Number: R00EY027846
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2020
PERIOD OF PERFORMANCE END DATE: 06/30/2025

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Perceptual stability during torsional eye movements - PROJECT SUMMARY/ABSTRACT A central question in vision research is how we perceive a stable world despite continuous retinal motion from eye movements. Understanding these mechanisms is critical to improving diagnosis and treatment of patients suffering from blurred or jumping vision, mislocalization of objects, abnormal tilt and slant perception, loss of balance and falls. Current models of perceptual stability during eye movements ignore the fact that the eye ro- tates around three axes. One important mechanism uses the efference copy of the command that moves the eyes to discount the retinal motion or displacement caused by eye movements. Research has focused on the horizontal and vertical dimensions of motion, overlooking the important contribution from the third (torsional) dimension, in which the eyes rotate around the line of sight, as happens, e.g., every time we tilt our head towards the shoul- der. Torsional eye position directly contributes to our perception of tilt (clockwise or counterclockwise) and of slant (orientation in the sagittal plane). The main reason for the gap in knowledge about torsion has been the technological challenge of reliably measuring torsion. We overcame this barrier by developing a new method for measuring torsional eye movements noninvasively. This proposal aims to study the perceptual effects and brain mechanisms of the efference copy for torsional eye movements. During the mentored phase, the candidate will use transcranial magnetic stimulation (TMS) combined with measurements of perception of upright, and tor- sional eye movement recordings to determine the role of particular cortical circuits in taking into account static torsion that occurs during static head tilts. During the independent phase, the candidate will study how percep- tion is altered around the time of quick torsional eye movements and during torsional vestibular ocular reflex. This will enable us to determine if the brain uses signals in three or two dimensions to compensate for the retinal motion induced by eye movements. These experiments will give us a unique opportunity to provide critical new evidence to modify and expand current models of perceptual stability. Studying torsion, we will be able to dis- criminate between computational models and brain areas that only account for the two dimensions of the retinal image versus those that account for all three dimensions of motion. Ultimately, understanding these mechanisms will provide new diagnostic and therapeutic avenues for people with unsteady vision, spatial disorientation, and falls.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$4,271 )
2025	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Vision Research	000	5	9/29/2025	NON-COMPETING CONTINUATION	-$4,271
														Subtotal = -$4,271

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Vision Research	000	5	7/3/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $248,873 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Vision Research	001	5	9/20/2022	NON-COMPETING CONTINUATION	$7,467
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Vision Research	000	5	6/16/2022	NON-COMPETING CONTINUATION	$241,406
														Subtotal = $248,873

Issue Date FY: 2021 ( Subtotal = $241,406 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Vision Research	001	4	6/2/2021	NON-COMPETING CONTINUATION	$241,406
2021	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Vision Research	000	3	10/22/2020	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $241,406

Issue Date FY: 2020 ( Subtotal = $248,350 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Vision Research	000	3	8/24/2020	EXTENSION WITH OR WITHOUT FUNDS	$248,350
														Subtotal = $248,350

Grand Total All Awards = $734,358

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Perceptual stability during torsional eye movements

Award Number: R00EY027846

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2020

PERIOD OF PERFORMANCE END DATE: 06/30/2025

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