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Coordination of Eye and Head Movements in Central Field Loss

Award Number: R00EY026994
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2016
PERIOD OF PERFORMANCE END DATE: 08/31/2022

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Coordination of Eye and Head Movements in Central Field Loss - ABSTRACT Age-related macular degeneration is the most common cause of vision loss in the central visual field, making central field loss (CFL) a major problem in the world today. Two-thirds of patients with CFL complain of vestibular problems, such as dizziness and instability, leading to a high incidence of potentially fatal accidents and falls. The problem is exacerbated by the patient population's advanced age, due to the documented decline in vestibular function in senescence. Vestibular deficits in CFL patients are likely due to miscalibrated or non-optimal stabilizing eye movements - many essential oculomotor behaviors are highly reliant on retinal input. Individuals with compromised vestibular responses have difficulties with visual field stability, navigation, and self- and external motion perception. These limitations are particularly true for CFL patients, whose visual acuity is already compromised and for whom the vestibular system becomes the predominant source of motion information. Furthermore, vestibular deficits likely affect patients' use of head movements to compensate for oculomotor limitations due to eccentric viewing and a patchy visual field. Despite the day-to-day importance of visual and vestibular interaction, these behaviors have not been comprehensively studied in CFL. This proposal seeks to address this gap. The first aim examines the contribution of head movements to smooth pursuit in CFL patients. This aim extends previous work quantifying smooth pursuit deficits in CFL to a more natural, head-unrestrained condition to determine if head movements are helpful or detrimental in CFL. Understanding the contribution of head movements can guide future rehabilitation strategies and clinical testing in this population. The second aim examines the effect of CFL on the angular vestibuloocular reflex (VOR). The reflex has little foveal dependence and is thus likely to be unaffected in CFL. However, foveal vision is known to contribute to both the calibration of this reflex and to its suppression when the head movement follows target motion. A deficit in any aspect of angular VOR will have consequences on the visual instability and vestibular discomfort of the affected individuals. Understanding these problems would inform necessary treatments in this population. The final aim examines the effects of CFL on translational VOR, a behavior that is completely fovea-dependent and is essential when body movement is present. Determining the degree of its impairment and exact influences of CFL is key to understanding vestibular dysfunction due to this visual deficit. VOR responses will be studied during passive and volitional, active motion. Previous research suggests fundamental differences in the processing of these two types of behavior, which indicates that they might be affected differently by central vision loss. If present, this dichotomy could have implications on how patients are advised and trained to interact with their environment while maintaining an active and productive lifestyle. Active behaviors (including head-free smooth pursuit) will be examined during the mentored portion of this project, while passive vestibular studies make up the bulk of the independent research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	SMITH-KETTLEWELL EYE RESEARCH INSTITUTE, THE	2318 FILLMORE ST	SAN FRANCISCO	CA	94115	SAN FRANCISCO	USA	Vision Research	000	5	5/8/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $229,882 )
2020	2020	SMITH-KETTLEWELL EYE RESEARCH INSTITUTE, THE	2318 FILLMORE ST	SAN FRANCISCO	CA	94115	SAN FRANCISCO	USA	Vision Research	001	5	8/17/2020	NON-COMPETING CONTINUATION	$229,882
2020	2019	SMITH-KETTLEWELL EYE RESEARCH INSTITUTE, THE	2318 FILLMORE ST	SAN FRANCISCO	CA	94115	SAN FRANCISCO	USA	Vision Research	000	3	3/5/2020	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $229,882

Issue Date FY: 2019 ( Subtotal = $273,413 )
2019	2019	SMITH-KETTLEWELL EYE RESEARCH INSTITUTE, THE	2318 FILLMORE ST	SAN FRANCISCO	CA	94115	SAN FRANCISCO	USA	Dietary Supplement Research Program	003	3	9/17/2019	SUPPLEMENT FOR EXPANSION	$30,329
2019	2019	SMITH-KETTLEWELL EYE RESEARCH INSTITUTE, THE	2318 FILLMORE ST	SAN FRANCISCO	CA	94115	SAN FRANCISCO	USA	Vision Research	002	4	8/2/2019	NON-COMPETING CONTINUATION	$242,212
2019	2018	SMITH-KETTLEWELL EYE RESEARCH INSTITUTE, THE	2318 FILLMORE ST	SAN FRANCISCO	CA	94115	SAN FRANCISCO	USA	Vision Research	000	3	2/10/2019	EXTENSION WITH OR WITHOUT FUNDS	$872
2019	2018	SMITH-KETTLEWELL EYE RESEARCH INSTITUTE, THE	2318 FILLMORE ST	SAN FRANCISCO	CA	94115	SAN FRANCISCO	USA	Vision Research	001	3	2/28/2019	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $273,413

Issue Date FY: 2018 ( Subtotal = $249,001 )
2018	2018	SMITH-KETTLEWELL EYE RESEARCH INSTITUTE, THE	2318 FILLMORE ST	SAN FRANCISCO	CA	94115	SAN FRANCISCO	USA	Vision Research	000	3	9/21/2018	EXTENSION WITH OR WITHOUT FUNDS	$249,001
														Subtotal = $249,001

Grand Total All Awards = $752,296

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Coordination of Eye and Head Movements in Central Field Loss

Award Number: R00EY026994

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2016

PERIOD OF PERFORMANCE END DATE: 08/31/2022

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