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Delineation of macrophage-derived transglutaminases' role in adipose tissue health and inflammation in obesity

Award Number: R00DK136921
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/15/2026
PERIOD OF PERFORMANCE END DATE: 03/31/2029

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Delineation of macrophage-derived transglutaminases' role in adipose tissue health and inflammation in obesity - PROJECT SUMMARY (See instructions): Obesity is a major public health burden that significantly increases the risk of type 2 diabetes (T2D). The way adipose tissue expands during weight gain-either via healthy hyperplasia or unhealthy hypertrophy critically influences metabolic outcomes. Unhealthy obesity is characterized by inflammation, fibrosis, and impaired glucose handling. Preliminary studies from my lab demonstrate that transglutaminases (TGases), enzymes involved in extracellular matrix (ECM) remodeling and immune regulation, drive maladaptive adipose expansion and chronic low-grade inflammation. The proposed ROO research will investigate the cell-specific roles of TGases in orchestrating adipose tissue dysfunction during obesity. Using conditional knockout mouse models and a novel lentiviral Cre system for temporally controlled gene deletion, we will examine TGase function in myeloid cells, Th17 cells, and adipocytes. These studies aim to define how TGases influence adipocyte expansion, immune cell dynamics, ECM remodeling, and systemic insulin sensitivity. By identifying TGases as immunometabolic regulators, this work will lay the foundation for targeted strategies to prevent or reverse obesity-associated metabolic disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $249,000 )
2026	2026	UNIVERSITY OF MARYLAND BALTIMORE COUNTY	1000 HILLTOP CIR	BALTIMORE	MD	21250	BALTIMORE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	7/15/2026	EXTENSION WITH OR WITHOUT FUNDS	$249,000
														Subtotal = $249,000

Grand Total All Awards = $249,000

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Delineation of macrophage-derived transglutaminases' role in adipose tissue health and inflammation in obesity

Award Number: R00DK136921

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/15/2026

PERIOD OF PERFORMANCE END DATE: 03/31/2029

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