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Bone-Like Organoids to Understand Factors Controlling Local Bone Immune Response and Regeneration

Award Number: R00DE033689
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/05/2026
PERIOD OF PERFORMANCE END DATE: 07/31/2029

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Bone-Like Organoids to Understand Factors Controlling Local Bone Immune Response and Regeneration - PROJECT SUMMARY Large defects in the bones of the face and jaw are common in dental and surgical care and place a major burden on patients and the healthcare system, costing over $1 billion each year. Current treatments often require bone grafts taken from another part of the body, which adds surgical risk and discomfort, and healing outcomes are difficult to predict. There is a critical need for better, less invasive approaches to repair craniofacial bone and to identify which patients are most likely to heal successfully. Recent studies suggest that the body’s immune response plays a key role in bone healing, but this relationship is poorly understood in craniofacial injuries, where wounds are exposed to the oral environment and its microbiome. During the mentored phase of this award, foundational tools were developed to address this gap, including bone-like organoids that mimic key features of human bone and a clinically relevant craniofacial defect model that reliably fails to heal without treatment. Early findings indicate that an abnormal immune response is present in response to unrepaired craniofacial defects. The goal of this R00 project is to determine how immune responses influence craniofacial bone healing and to establish bone-like organoids as tools to predict and improve healing outcomes. This work will identify immune patterns associated with successful versus failed healing, develop models to predict outcomes before healing is complete, and create patient-specific bone-like organoids that can be used to test regenerative therapies. Together, these studies will advance personalized approaches to craniofacial bone repair and support the development of more effective, immune-informed treatments for dental and craniofacial patients.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $249,000 )
2026	2026	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD AVE M/C 551	CHICAGO	IL	60612	COOK	USA	Oral Diseases and Disorders Research	000	3	8/6/2026	EXTENSION WITH OR WITHOUT FUNDS	$249,000
														Subtotal = $249,000

Grand Total All Awards = $249,000

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Bone-Like Organoids to Understand Factors Controlling Local Bone Immune Response and Regeneration

Award Number: R00DE033689

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/05/2026

PERIOD OF PERFORMANCE END DATE: 07/31/2029

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