Monday, September 15, 2025 9/15/2025

GABA and NPY signaling interact to shape inhibition in the auditory tectothalamic pathway

Award Number: R00DC019415
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/01/2021
PERIOD OF PERFORMANCE END DATE: 12/31/2026

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GABA and NPY signaling interact to shape inhibition in the auditory tectothalamic pathway - Inhibition critically shapes auditory signal processing, impacting nearly every aspect of hearing. In the inferior colliculus (IC), inhibition shapes how neurons respond to auditory cues that are essential for speech and vocalization processing, including frequency tuning curves and directional selectivity for frequency modulated (FM) sweeps. In addition, diminished synaptic inhibition is a critical feature in age-related hearing loss. The IC is considered the hub of the central auditory pathway, and despite the crucial role of inhibition in the IC, the cellular mechanisms underlying GABAergic inhibition remain largely unknown. This gap in our understanding exists because it has been proven difficult to identify distinct GABAergic neuron types in the IC. We recently overcame this problem by identifying Neuropeptide Y (NPY) expression as a marker for a novel class of inhibitory principal neurons in the IC. NPY neurons are GABAergic, have a stellate morphology and project to the auditory thalamus (MG). In addition, we found that NPY signaling dampens the excitability of a large family of IC glutamatergic neurons that express the NPY Y1 receptor (Y1R). In this proposal, we will investigate how the co-release of NPY and GABA affects auditory processing in vivo. The overall objective of this research is to determine how NPY and GABA signaling from a defined class of IC GABAergic neurons influence Y1R neurons to shape frequency tuning and FM sweep direction selectivity in the auditory tectothalamic pathway. We will further determine whether augmenting NPY signaling improves features of auditory processing in the IC and MG that are disrupted in a mouse model of aging. To pursue these objectives, we will use in vitro and in vivo electrophysiology, combined with pharmacology, chemogenetics and optogenetics. Aim 1. We will perform in vivo recordings in the IC-MG pathway while using chemogenetics and optogenetics to modulate NPY and GABAergic signaling. This aim will determine how NPY signaling shapes the tonal receptive fields and FM sweep direction selectivity of neurons in the IC and MG. In Aim 2, we will use electrophysiology and viral tract tracing to investigate how NPY and Y1R neurons interact to shape postsynaptic activity in the MG. We will further determine how excitatory-inhibitory interactions in this circuit are affected in a mouse model of aging. This research will provide a mechanistic understanding of how a distinct subtype of GABAergic neuron interacts with neuropeptide signaling in the IC to shape auditory computations in the tectothalamic pathway.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $352,912 )
2025	2025	THE UNIVERSITY OF TEXAS AT SAN ANTONIO	1 UTSA CIR	SAN ANTONIO	TX	78249	BEXAR	USA	Research Related to Deafness and Communication Disorders	000	4	12/17/2024	NON-COMPETING CONTINUATION	$224,100
2025	2025	THE UNIVERSITY OF TEXAS AT SAN ANTONIO	1 UTSA CIR	SAN ANTONIO	TX	78249	BEXAR	USA	Research Related to Deafness and Communication Disorders	001	4	5/9/2025	NON-COMPETING CONTINUATION	$24,900
2025	2025	THE UNIVERSITY OF TEXAS AT SAN ANTONIO	1 UTSA CIR	SAN ANTONIO	TX	78249	BEXAR	USA	Research Related to Deafness and Communication Disorders	002	4	8/20/2025	SUPPLEMENT FOR EXPANSION	$103,912
														Subtotal = $352,912

Issue Date FY: 2024 ( Subtotal = $249,042 )
2024	2024	UNIVERSITY OF TEXAS AT SAN ANTONIO, THE	1 UTSA CIRCLE	SAN ANTONIO	TX	78249	BEXAR	USA	Research Related to Deafness and Communication Disorders	000	3	1/17/2024	EXTENSION WITH OR WITHOUT FUNDS	$249,000
2024	2024	THE UNIVERSITY OF TEXAS AT SAN ANTONIO	1 UTSA CIR	SAN ANTONIO	TX	78249	BEXAR	USA	Research Related to Deafness and Communication Disorders	001	3	5/7/2024	EXTENSION WITH OR WITHOUT FUNDS	$42
														Subtotal = $249,042

Grand Total All Awards = $601,954

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GABA and NPY signaling interact to shape inhibition in the auditory tectothalamic pathway

Award Number: R00DC019415

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/01/2021

PERIOD OF PERFORMANCE END DATE: 12/31/2026

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