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Identifying and Treating Childhood Apraxia of Speech in Minimally Verbal Children with Autism

Award Number: R00DC017490
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2019
PERIOD OF PERFORMANCE END DATE: 11/30/2025

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Identifying and Treating Childhood Apraxia of Speech in Minimally Verbal Children with Autism - Although one in four children with autism remain minimally verbal past age five, we do not know all the factors that limit spoken language in these minimally verbal children with autism. One powerful contributor may be a concomitant motor speech disorder, Childhood Apraxia of Speech (CAS). CAS is an impairment in the ability to plan and sequence for speech, which renders speech inconsistent and imprecise. But because producing intelligible speech is a prerequisite to acquiring spoken language, there is an urgent need to understand how CAS may affect speech movements and intelligibility in minimally verbal children with autism, and to develop interventions that incorporate strategies to address CAS, when present. This project proposes three studies to investigate the relationship between CAS and speech in minimally verbal children with autism and CAS. First, we compare a group of 11 minimally verbal children with autism who meet criteria for CAS to a group of 11 who do not meet criteria for CAS. We hypothesize that facial movement tracking, a non-invasive method to investigate speech motor function, will reveal that the +CAS group show lower movement consistency and precision than the –CAS group. Next, we investigate the relationship of clinical signs of CAS to speech movement parameters and to intelligibility. We hypothesize that more severe CAS predicts lower movement consistency and precision, and lower intelligibility, in an additional group of 22 minimally verbal children with autism+CAS. Finally, we use the previous investigations to inform treatment for a group of 20 minimally verbal children with autism+CAS. First we identify the speech movements for each child that are both disordered and degrade intelligibility,. Then, we create a set of mono- and bisyllabic stimuli involving these movements and train participants on a subset of them in a series of single-subject experiments. Treatment will involve principles of motor learning (massed and distributed practice) and dynamic cueing, which have been shown to be effective for treating CAS. Both perceptual (intelligibility-based) and objective (movement-based) outcome measures will demonstrate the extent to which this targeted treatment improves speech production in these children. The findings will inform clinical practice for minimally verbal children with autism and lead to the development of novel interventions for this severely affected population.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	THE MGH INSTITUTE OF HEALTH PROFESSIONS, INC.	36 1ST AVE	CHARLESTOWN	MA	02129	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	6	2/19/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $346,960 )
2024	2024	THE MGH INSTITUTE OF HEALTH PROFESSIONS, INC.	36 1ST AVE	CHARLESTOWN	MA	02129	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	002	6	5/2/2024	NON-COMPETING CONTINUATION	$24,898
2024	2024	THE MGH INSTITUTE OF HEALTH PROFESSIONS, INC.	36 1ST AVE	CHARLESTOWN	MA	02129	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	001	6	3/19/2024	SUPPLEMENT FOR EXPANSION	$97,984
2024	2024	THE MGH INSTITUTE OF HEALTH PROFESSIONS, INC.	36 1ST AVE	CHARLESTOWN	MA	02129	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	6	12/20/2023	NON-COMPETING CONTINUATION	$224,078
														Subtotal = $346,960

Issue Date FY: 2023 ( Subtotal = $248,976 )
2023	2023	MGH INSTITUTE OF HEALTH PROFESSIONS, INC.THE	36 1ST AVE	BOSTON	MA	02129	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	001	5	1/14/2023	NON-COMPETING CONTINUATION	$24,898
2023	2023	MGH INSTITUTE OF HEALTH PROFESSIONS, INC.THE	36 1ST AVE	BOSTON	MA	02129	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	5	11/24/2022	NON-COMPETING CONTINUATION	$224,078
														Subtotal = $248,976

Issue Date FY: 2022 ( Subtotal = $248,976 )
2022	2022	MGH INSTITUTE OF HEALTH PROFESSIONS, INC.THE	36 1ST AVE	BOSTON	MA	02129	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	000	4	11/23/2021	EXTENSION WITH OR WITHOUT FUNDS	$248,976
														Subtotal = $248,976

Grand Total All Awards = $844,912

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Identifying and Treating Childhood Apraxia of Speech in Minimally Verbal Children with Autism

Award Number: R00DC017490

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2019

PERIOD OF PERFORMANCE END DATE: 11/30/2025

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