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Integration of multi-omics to predict and evaluate response during optimization of a nutrition intervention for cancer survivors with overweight and obesity

Award Number: R00CA287061
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2024
PERIOD OF PERFORMANCE END DATE: 04/30/2029

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Integration of multi-omics to predict and evaluate response during optimization of a nutrition intervention for cancer survivors with overweight and obesity - PROJECT SUMMARY Cancer survivors with overweight or obesity (ow/ob) display increased morbidity and mortality even after amelioration of disease. Improvements in dietary and physical activity patterns can mitigate this risk and can be supported through comprehensive, multiple health behavior change (MHBC) interventions. Yet, translation of MHBC interventions to clinical practice is limited, in part because traditional “treatment package” approaches are not optimized for real-world implementation. Integration of multi-omic data can capture lifestyle exposures and biological responses, providing the potential to strengthen conclusions and overcome limitations of existing assessment methods. This approach could elucidate the biological underpinnings of how changes in modifiable behaviors influence individual phenotype during survivorship. Such knowledge would help to identify and tailor interventions for incorporation into survivorship care. Yet, this has not been conducted, posing a critical research gap. My goal is to create a sustainable and scalable MHBC program combining diet and exercise to support survivors with ow/ob and improve health in survivorship. Thus, the overall objectives for this NCI early K99/R00 award are to: (1) develop a survivorship nutrition intervention, BfedBwell, for implementation within an existing clinical exercise oncology program; and (2) determine the impact of the intervention on diet and health through the integration of multi-omic approaches. In the K99 phase, I will utilize the Multiphase Optimization Strategy (MOST) framework, an engineering-based approach to efficiently and systematically develop, optimize, and evaluate behavioral interventions, to test three social cognitive theory-based components: (1) 1:1 counseling with a registered dietitian, (2) behavioral skills development, and (3) group support for delivery alongside a core nutrition education curriculum within a clinical exercise oncology program. Post-treatment survivors (n=80) with ow/ob will complete a 12-week cluster-randomized 2^3 factorial trial to test candidate intervention components for feasibility and acceptability and to identify a set of components that demonstrates patterns of efficacy for increased adherence to lifestyle recommendations, weight loss, and improvements in cardiometabolic health. In the R00 phase, I will utilize targeted metabolomics to measure changes in biomarkers of dietary exposure through analysis of participant biospecimens collected before and after the intervention. I will then perform integrated network analysis using multi-omics (metabolome, proteome, microbiome) to examine the effects of the intervention on cardiometabolic health. My K99 mentorship and training plan will provide skills in behavioral weight loss trials, MOST study design, and multi-omics integration in survivorship. The R00 phase will advance my foundational knowledge as I become an expert in identifying and interpreting multi-omic findings and integrating them into behavioral interventions to predict and evaluate individual response. Completion of these aims will lay the groundwork for an R01-level optimization trial, leading to advances in care while spanning behavioral and biological domains to develop precision oncology nutrition strategies for improved survivorship.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $249,000 )
2026	2026	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Cancer Treatment Research	000	3	7/1/2026	EXTENSION WITH OR WITHOUT FUNDS	$249,000
														Subtotal = $249,000

Grand Total All Awards = $249,000

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Integration of multi-omics to predict and evaluate response during optimization of a nutrition intervention for cancer survivors with overweight and obesity

Award Number: R00CA287061

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2024

PERIOD OF PERFORMANCE END DATE: 04/30/2029

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