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Investigating Cellular Communication in the Tumor Microenvironment in Pancreatic Cancer

Award Number: R00CA263154
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/28/2025
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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Investigating Cellular Communication in the Tumor Microenvironment in Pancreatic Cancer - PROJECT ABSTRACT Pancreatic cancer is a deadly malignancy that is highly resistant to current therapies. Further, this disease does not impact all racial groups equally. Black African American (BAA) individuals are 20% more likely to develop pancreatic cancer, and have worse outcomes compared to White patients. Even controlling for numerous factors such as environment, socioeconomic status, health behaviors, and other common causes of disparities, these differences remain. Thus, it is critical to address underlying biological mechanisms of racial disparities. We have previously shown that the developmental signaling pathway SLIT-ROBO is globally down-regulated in pancreatic cancer compared to normal pancreas. Our single cell RNA sequencing data show SLIT ligands are produced by pericytes and cancer associated fibroblasts, while ROBO receptors are more broadly distributed across endocrine, fibroblasts, and blood vessels. Prior studies and our preliminary data lead us to hypothesize that this pathway plays a tumor- suppressive role in pancreatic cancer. However, it is unknown if this loss is observed equally across different racial groups. Unfortunately, our current single cell RNA sequencing atlas build from published studies is only 4 BAA patients and 196 White patients. Here we propose to generate key new single cell RNA sequencing data from a diverse cohort of pancreatic cancer patients (n=75 White and n=75 BAA) to address this urgent and unmet need.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	HENRY FORD HEALTH SYSTEM	1 FORD PL # 5B	DETROIT	MI	48202	WAYNE	USA	Cancer Research Manpower	000	4	11/20/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	CINCINNATI UNIV OF	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Cancer Research Manpower	001	5	9/3/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$64,053
2025	2024	HENRY FORD HEALTH SYSTEM	1 FORD PL	DETROIT	MI	48202	WAYNE	USA	Cancer Research Manpower	000	4	9/3/2025	NON-COMPETING CONTINUATION	-$64,053
2025	2024	HENRY FORD HEALTH SYSTEM	1 FORD PL	DETROIT	MI	48202	WAYNE	USA	Cancer Research Manpower	002	4	9/4/2025	SUPPLEMENT FOR EXPANSION	-$10,355
2025	2024	CINCINNATI UNIV OF	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Cancer Research Manpower	003	5	9/12/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$10,355
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $424,891 )
2024	2024	HENRY FORD HEALTH SYSTEM	1 FORD PL	DETROIT	MI	48202	WAYNE	USA	Cancer Research Manpower	003	4	9/12/2024	SUPPLEMENT FOR EXPANSION	-$33,047
2024	2024	HENRY FORD HEALTH SYSTEM	1 FORD PL	DETROIT	MI	48202	WAYNE	USA	Cancer Research Manpower	002	4	8/27/2024	NON-COMPETING CONTINUATION	$101,000
2024	2024	HENRY FORD HEALTH SYSTEM	1 FORD PL	DETROIT	MI	48202	WAYNE	USA	Cancer Research Manpower	001	4	8/26/2024	SUPPLEMENT FOR EXPANSION	$107,939
2024	2024	HENRY FORD HEALTH SYSTEM	1 FORD PL	DETROIT	MI	48202	WAYNE	USA	Cancer Research Manpower	000	4	7/29/2024	NON-COMPETING CONTINUATION	$248,999
														Subtotal = $424,891

Issue Date FY: 2023 ( Subtotal = $187,922 )
2023	2023	HENRY FORD HEALTH SYSTEM	1 FORD PL	DETROIT	MI	48202	WAYNE	USA	Cancer Research Manpower	001	3	7/26/2023	NON-COMPETING CONTINUATION	$187,922
2023	2022	HENRY FORD HEALTH SYSTEM	1 FORD PL	DETROIT	MI	48202	WAYNE	USA	Cancer Research Manpower	000	2	11/23/2022	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $187,922

Issue Date FY: 2022 ( Subtotal = $249,000 )
2022	2022	HENRY FORD HEALTH SYSTEM	1 FORD PL	DETROIT	MI	48202	WAYNE	USA	Cancer Research Manpower	000	2	8/19/2022	EXTENSION WITH OR WITHOUT FUNDS	$249,000
														Subtotal = $249,000

Grand Total All Awards = $861,813

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Investigating Cellular Communication in the Tumor Microenvironment in Pancreatic Cancer

Award Number: R00CA263154

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/28/2025

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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