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Community Empowerment, Vascular Risk, and ADRD Disparities: Translating Research to Public Policy

Award Number: R00AG083121
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2023
PERIOD OF PERFORMANCE END DATE: 02/28/2029

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Community Empowerment, Vascular Risk, and ADRD Disparities: Translating Research to Public Policy - By 2050, racial disparities will persist among the projected 11 million adults with Alzheimer’s Disease and Related Dementias (AD/ADRD). Prior research links factors to AD/ADRD, highlighting the need for policy solutions to mitigate the racially-patterned cardiovascular disease (CVD) burden that accelerates AD/ADRD onset. Economic disinvestment prevents majority-Black and majority-poor neighborhoods from investing in their local infrastructure. These economic factors limit community engagement among the very groups whose cardiovascular and cognitive health would benefit most from effective health policy. However, it is not known how lower investment and disengagement contribute to AD/ADRD disparities via excess CVD risk. This proposed K99/R00 harnesses the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study, Health and Retirement Study (HRS), and administrative claims from Medicare Beneficiaries. For my K99 phase, I will identify indicators of lower economic investment or social disengagement that worsen AD/ADRD trajectories and widen racial disparities in REGARDS and HRS. Then I will use these results to calculate the population attributable fraction of lower investment and disengagement on AD/ADRD among Medicare Beneficiaries. During my R00 phase, I will analyze the mediating role of CVD in associations of community resources (economic investment and social engagement) and incident AD/ADRD in Medicare claims. Finally, I will utilize the CVD Policy Model to forecast nationwide community empowerment policies that reduce CVD risk factors for AD/ADRD up to three decades in the future. Building upon my foundation of data science, causal inference, and CVD epidemiology, my training plan consists of new knowledge domains: 1) AD/ADRD science, 2) spatial modeling, 3) Medicare claims, and 4) estimation of public health impact attainable with community interventions. Based at the richly resourced Boston University School of Public Health, I have assembled a team of distinguished mentors with the ideal combination of expertise to facilitate my success. The integrated science, training, mentorship, and professional development will prepare me for a faculty position at an R1 institution. My long-term goal is to become an independent investigator who develops interventions and policies to prevent AD/ADRD among high-risk communities.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $249,000 )
2026	2026	TRUSTEES OF BOSTON UNIVERSITY	85 EAST NEWTON ST # M-921	BOSTON	MA	02118	SUFFOLK	USA	Aging Research	000	3	2/26/2026	EXTENSION WITH OR WITHOUT FUNDS	$249,000
														Subtotal = $249,000

Grand Total All Awards = $249,000

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Community Empowerment, Vascular Risk, and ADRD Disparities: Translating Research to Public Policy

Award Number: R00AG083121

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2023

PERIOD OF PERFORMANCE END DATE: 02/28/2029

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