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Age and sex differences in the immune response to synthetic materials

Award Number: R00AG081564
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/15/2023
PERIOD OF PERFORMANCE END DATE: 03/31/2028

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Age and sex differences in the immune response to synthetic materials - Project Summary The WHO estimates that 1 in 6 people will be 60 years or older by 2030. A hallmark of aging is the immunological changes that increase susceptibility of this population to inflammatory agerelated diseases, hinder response to infections and vaccines, and lower regenerative capacity. Synthetic biomaterials are used in multiple ways including drug delivery, vaccines, prosthetics, and scaffolds in tissue engineering to promote tissue regeneration. Implanting a biomaterial creates an injury and initiates the immune-driven development of a foreign body reaction. Immune-tissue engineering solutions must be designed to modulate the local microenvironment while overcoming the FBR. With an aging population there is a critical need to understand the age-specific immune-material interactions to rationally design biomaterial solutions for tissue engineering. The goal is to identify key material design criteria that effectively modulate aged immune cells. The overarching hypothesis is that the aged immune dysregulation towards an effector state compounds the adverse reaction to synthetic materials and prevents scaffolds from functioning as designed. My proposed research for the R00 focuses on designing materials for the aged immune system to reduce fibrosis and promote tissue regeneration. The goal of the R00 is split into 3 aims to understand how we can optimally design materials to promote a desired immune response in aged cells accounting for biologic sex targeting the innate (Aim 1) and adaptive (Aim 2) immune system and how both arms of the immune system (Aim 3) can be used to promote regeneration.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $244,998 )
2025	2025	GEORGIA TECH APPLIED RESEARCH CORP	926 DALNEY ST NW	ATLANTA	GA	30318	FULTON	USA	Aging Research	000	3	8/6/2025	EXTENSION WITH OR WITHOUT FUNDS	$244,998
														Subtotal = $244,998

Grand Total All Awards = $244,998

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Age and sex differences in the immune response to synthetic materials

Award Number: R00AG081564

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/15/2023

PERIOD OF PERFORMANCE END DATE: 03/31/2028

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