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Investigating cerebrovascular regulation during exercise as a factor influencing cortical resource engagement for balance control with aging

Award Number: R00AG075255
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/15/2024
PERIOD OF PERFORMANCE END DATE: 02/28/2027

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Investigating cerebrovascular regulation during exercise as a factor influencing cortical resource engagement for balance control with aging - PROJECT SUMMARY/ABSTRACT During the aging process there is a loss of automaticity in balance and mobility, where the engagement of cortical resources for balance control may interfere with older adults’ ability to perform cognitive and balance behaviors simultaneously. Over the course of normal aging, there is a decline in cerebral blood flow that is linked to impaired cognitive function in older adults. However, it remains unknown whether age-related declines in cerebrovascular and nervous system function may interact to manifest as cognitive interference in balance control that precipitate falls and clinical dementia. Further, older adults who carry the Apolipoprotein E4 (APOE4) allele, the greatest known genetic risk factor for Alzheimer’s disease, show greater cerebrovascular dysfunction compared to age-matched noncarriers, and display worse balance performance under cognitive loading conditions, supporting the potential effect of individual genotype on the link between cerebrovascular health and balance control with aging. Using electroencephalography (EEG) to measure dynamic cortical activity during standing balance reactions, the candidate’s recent fellowship findings provide an individualized framework of cortical engagement strategies for balance control in older adults that is associated with distinct aspects of balance behavior and fall risk, including cognitive interference in balance performance. Currently, a major scientific barrier to the clinical translation of this research is the lack of understanding of the factors that influence individual-specific cortical strategies for balance control with aging. Emerging evidence suggests cognitive impairment with aging may be caused by dysfunctional cerebral blood flow, specifically characterized by impaired cerebrovascular regulation under conditions of physiologic stress. Blunted cerebral blood flow response to an acute bout aerobic exercise, an assessment method pioneered by Dr. Billinger (primary mentor) and her laboratory, appears to be an early indicator of dysfunctional cerebrovascular regulation in preclinical older adult populations. The proposed project will be the first to test the link between cerebrovascular regulation during an acute bout of aerobic exercise, measured as cerebral blood flow velocity using transcranial Doppler ultrasound, and cortical function during balance behavior with aging, measured with cognitive dual-task balance performance (Aim 1) and EEG measures of cortical activity during balance reactions (Aim 2). An Exploratory Aim will test whether genetic APOE4 carrier status alters the relationship between cerebrovascular regulation and balance control in older adults. The scientific knowledge gained from these studies would create an individualized framework for understanding cardiovascular-nervous system interactions that may contribute to balance disability in older adults. This framework would provide a foundation for the development of precision-medicine strategies for fall prevention, particularly in individuals at high risk for Alzheimer’s disease and subsequent falls.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $248,960 )
2026	2026	REGENTS OF THE UNIVERSITY OF MINNESOTA	2221 UNIVERSITY AVE SE STE 100	MINNEAPOLIS	MN	55414	HENNEPIN	USA	Aging Research	000	5	2/27/2026	NON-COMPETING CONTINUATION	$248,960
														Subtotal = $248,960

Issue Date FY: 2025 ( Subtotal = $243,981 )
2025	2025	REGENTS OF THE UNIVERSITY OF MINNESOTA	2221 UNIVERSITY AVE SE STE 100	MINNEAPOLIS	MN	55414	HENNEPIN	USA	Aging Research	000	4	3/7/2025	NON-COMPETING CONTINUATION	$224,065
2025	2025	REGENTS OF THE UNIVERSITY OF MINNESOTA	2221 UNIVERSITY AVE SE STE 100	MINNEAPOLIS	MN	55414	HENNEPIN	USA	Aging Research	001	4	6/9/2025	NON-COMPETING CONTINUATION	$19,916
2025	2025	REGENTS OF THE UNIVERSITY OF MINNESOTA	2221 UNIVERSITY AVE SE STE 100	MINNEAPOLIS	MN	55414	HENNEPIN	USA	Aging Research	002	4	8/4/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $243,981

Issue Date FY: 2024 ( Subtotal = $339,341 )
2024	2024	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Aging Research	000	3	3/15/2024	EXTENSION WITH OR WITHOUT FUNDS	$249,000
2024	2024	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Aging Research	001	3	8/8/2024	EXTENSION WITH OR WITHOUT FUNDS	$90,341
														Subtotal = $339,341

Grand Total All Awards = $832,282

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Investigating cerebrovascular regulation during exercise as a factor influencing cortical resource engagement for balance control with aging

Award Number: R00AG075255

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/15/2024

PERIOD OF PERFORMANCE END DATE: 02/28/2027

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