Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Biological Aging, the Proteome and Cognitive Resilience among Ischemic Stroke Survivors

Award Number: R00AG075196
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/15/2023
PERIOD OF PERFORMANCE END DATE: 12/31/2028

Group Awards By:

View Award Description

Biological Aging, the Proteome and Cognitive Resilience among Ischemic Stroke Survivors - To date there is no disease-modifying therapy for cognitive impairment and dementia. Understanding mechanisms that strengthen cognitive resilience and delay vascular dementia is a complimentary approach to protect cognitive health in aging. Survivors of stroke and vascular disorders are rapidly growing in the U.S. and can rapidly progress to vascular dementia. Cognitive trajectories assessed over long durations of follow-up, allow monitoring of cognitive resilience and timing of dementia onset. Tau and Beta-amyloid pathologies, infarction and stroke-related factors leave ~ 59% of the variance in cognitive trajectory unexplained. Mechanisms that elicit differences in cognitive resilience and timing of vascular dementia onset, remain unclear. Biological aging is the decline in system integrity with advancing chronological age and has been associated with age-related diseases. Biological aging can be measured by composite algorithms of biomarkers’ combinations in routine blood-tests to assess the underlying body integrity at the physiological level. However, it remains poorly understood if biological aging explains variabilities in post-stroke cognitive resilience and timing of vascular dementia onset. At the molecular level, among aging biology mechanisms, the proteome is hypothesized to play a central role in cognitive resilience and brain health. Proteins control cell functions, can help identify novel therapeutic targets and have been associated with cognitive trajectories in postmortem assessments. Aging-related proteomic changes are best detected in the systemic circulation. Proteomic technologies allow measuring protein changes in aging with high levels of specificity and precision. Establishing molecular proteomic pathways of cognitive resilience in survivors of stroke and vascular disorders, is a critical step to translate biomarker discoveries to dementia treatment and therapeutics. The immediate objective of this application is to assess the role of biological aging and molecular proteomic mechanisms in cognitive resilience and onset of dementia in the context of stroke and vascular disorders for prevention and to identify new therapeutics. I will measure vascular and biological aging phenotypes in population-based studies such as the Baltimore Longitudinal Study of Aging, the Cardiovascular Health Study, the Health and Retirement Study and the Rotterdam Study. I will integrate these phenotypes with state-of-the art clinical ascertainment of vascular disorders and dementia over long durations of follow-up. I will leverage proteomic platforms (e.g. aptamer-based, antibody-based) to identify molecular cellular pathways of biological aging and cognitive resilience in survivors of stroke, vascular disorders and healthy controls. I will lastly evaluate algorithms of combined molecular, proteomic and clinical data to monitor cognitive and vascular health using semi-supervised machine learning approaches. This project will enable actionable findings on molecular mechanisms of cognitive resilience to uncover novel therapeutic targets and biomarkers for dementia prevention in aging.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $249,000 )
2026	2026	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Aging Research	000	3	1/29/2026	EXTENSION WITH OR WITHOUT FUNDS	$224,101
2026	2026	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Aging Research	002	3	2/25/2026	EXTENSION WITH OR WITHOUT FUNDS	$24,899
2026	2026	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Aging Research	001	3	2/11/2026	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $249,000

Grand Total All Awards = $249,000

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Biological Aging, the Proteome and Cognitive Resilience among Ischemic Stroke Survivors

Award Number: R00AG075196

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/15/2023

PERIOD OF PERFORMANCE END DATE: 12/31/2028

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer