Friday, July 4, 2025 7/4/2025

The neural basis for aging-dependent decline in taste function

Award Number: R00AG071833
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2021
PERIOD OF PERFORMANCE END DATE: 12/31/2025

Group Awards By:

View Award Description

The neural basis for aging-dependent decline in taste function - PROJECT SUMMARY Deficits in chemosensory processing are associated with healthy aging, as well as numerous neurodegenerative disorders including Alzheimer’s Disease (AD). In many cases, chemosensory deficits are harbingers of neurodegenerative disease, and understanding the mechanistic basis for these changes may provide insight into fundamental dysfunction associated with aging and neurodegeneration. The genetic and physiological accessibility of chemosensory neurons and their defined higher order processing centers provide a unique opportunity to investigate the effects of aging-related processes on neural function, including sensory responsiveness, plasticity, and synaptic connectivity. The fruit fly, Drosophila melanogaster, is a powerful model for studying chemosensation, aging, and aging-related pathologies, yet the effects of aging on chemosensation remain largely unexplored in this model, particularly with respect to taste. A large genetic toolkit combined with functional imaging allow for cell-type specific manipulation of taste circuits. Numerous models of AD been developed in Drosophila that largely phenocopy two hallmarks of AD: amyloid beta (Aβ)-mediated toxicity and tauopathy caused by hyperphosphorylation of the Tau protein. My preliminary findings reveal that taste perception and taste memory deteriorate with age, and this is exacerbated in a fly model of AD. Here, I will examine the physiological and molecular basis for age-associated reduction in taste and taste memory in models of natural and pathological aging. These experiments build on my expertise in chemosensory processing and functional imaging, while providing training in aging and genomic approaches.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $220,071 )
2025	2025	FLORIDA STATE UNIVERSITY	874 TRADITIONS WAY	TALLAHASSEE	FL	32306	LEON	USA	Aging Research	000	4	12/6/2024	NON-COMPETING CONTINUATION	$220,071
2025	2025	FLORIDA STATE UNIVERSITY	874 TRADITIONS WAY	TALLAHASSEE	FL	32306	LEON	USA	Aging Research	001	4	5/29/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $220,071

Issue Date FY: 2024 ( Subtotal = $260,431 )
2024	2024	FLORIDA STATE UNIVERSITY	874 TRADITIONS WAY	TALLAHASSEE	FL	32306	LEON	USA	Aging Research	000	3	1/11/2024	EXTENSION WITH OR WITHOUT FUNDS	$249,000
2024	2024	FLORIDA STATE UNIVERSITY	874 TRADITIONS WAY	TALLAHASSEE	FL	32306	LEON	USA	Aging Research	001	3	4/5/2024	EXTENSION WITH OR WITHOUT FUNDS	$11,431
														Subtotal = $260,431

Grand Total All Awards = $480,502

Top

All Categories

About

Search

Reports

Data Submission

Award Information

The neural basis for aging-dependent decline in taste function

Award Number: R00AG071833

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2021

PERIOD OF PERFORMANCE END DATE: 12/31/2025

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer