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Dietary Protein Restriction Remodels Adipose Tissue to Defend Against Age-Related Metabolic Decline

Award Number: R00AG070273
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2021
PERIOD OF PERFORMANCE END DATE: 05/31/2025

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Dietary Protein Restriction Remodels Adipose Tissue to Defend Against Age-Related Metabolic Decline - Abstract Adipose tissue is a critical endocrine mediator of metabolic health that is functionally altered during aging and obesity. Our data demonstrate that dietary protein restriction (DPR) increases whole body glucose homeostasis and energy expenditure and protects against age-related metabolic decline, and that these metabolic effects are associated with a remodeling of white adipose tissue that includes increased thermogenic markers and adiponectin secretion. This project tests the hypothesis that the remodeling of adipose tissue during dietary protein restriction directly improves metabolic health during aging. This model will be tested by assessing the transcriptional and cell signaling pathways in adipose tissue that contribute to glucose homeostasis and insulin sensitivity and determining which of these are altered during DPR in an age- dependent fashion. Lastly, we will test whether increases in adiponectin contribute to whole body improvements in glucose homeostasis during protein restriction, and whether using adipose tissue grafts from protein restricted mice combats age-related insulin resistance in an adiponectin-dependent manner.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Aging Research	000	4	5/27/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $330,343 )
2024	2024	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90089	LOS ANGELES	USA	Aging Research	002	4	5/9/2024	NON-COMPETING CONTINUATION	$245,176
2024	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Aging Research	000	3	11/10/2023	EXTENSION WITH OR WITHOUT FUNDS	$0
2024	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Aging Research	001	3	12/8/2023	EXTENSION WITH OR WITHOUT FUNDS	$85,167
														Subtotal = $330,343

Issue Date FY: 2023 ( Subtotal = $248,884 )
2023	2023	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST	LOS ANGELES	CA	90089	LOS ANGELES	USA	Aging Research	000	3	8/24/2023	EXTENSION WITH OR WITHOUT FUNDS	$248,884
														Subtotal = $248,884

Grand Total All Awards = $579,227

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Dietary Protein Restriction Remodels Adipose Tissue to Defend Against Age-Related Metabolic Decline

Award Number: R00AG070273

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2021

PERIOD OF PERFORMANCE END DATE: 05/31/2025

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