Saturday, February 7, 2026 2/7/2026

Parietal-hippocampal network in the triple transgenic mouse model of Alzheimers

Award Number: R00AG049090
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2016
PERIOD OF PERFORMANCE END DATE: 04/30/2021

Group Awards By:

View Award Description

Parietal-hippocampal network in the triple transgenic mouse model of Alzheimers - Alzheimer’s disease is devastating for both individuals and society. Getting lost and memory impairments are major symptoms of the disease. Similarly, rodent models of Alzheimer’s disease also ‘get lost’ (e.g., impaired spatial navigation). Emerging evidence suggests abnormal communication between the posterior parietal cortex (PPC) and hippocampus in humans with Alzheimer’s. The objective of the proposed research is to explore the functionality of the hippocampal-PPC network in an animal model of amyloidosis, in order to assess potential contributions of altered cortico-hippocampal function to Alzheimer’s disease. To do this, I will focus on the triple transgenic mouse model of Alzheimer’s where three major genes associated with familial Alzheimer’s disease are expressed. This mouse model mimics both plaque and tangle pathological hallmarks of the disease with a distribution pattern similar to human patients, including synaptic changes in the limbic system. Specifically, in three different experiments I will: a) continue to assess hippocampal population activity as a potential cause of impairments in triple transgenic mice in using an external (room based) reference frame when their internal position reference frame is disrupted; b) continue to assess both rest related memory replay and functional synaptic connectivity within and across the hippocampus and PPC in the triple transgenic mouse; c) utilize a novel pharmacogenetic approach to test the theory that temporary and specific hippocampal inactivation will produce impairments in memory replay that mimic those seen in animal models. Finally, findings in the triple transgenic model will be confirmed in a newer model of Alzheimer’s that is more similar to sporadic Alzheimer’s in humans.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = -$335 )
2021	2019	FLORIDA STATE UNIVERSITY	874 TRADITIONS WAY	TALLAHASSEE	FL	32306	LEON	USA	Aging Research	000	5	8/24/2021	NON-COMPETING CONTINUATION	-$335
														Subtotal = -$335

Issue Date FY: 2019 ( Subtotal = $249,000 )
2019	2019	FLORIDA STATE UNIVERSITY	874 TRADITIONS WAY	TALLAHASSEE	FL	32306	LEON	USA	Aging Research	000	5	4/15/2019	NON-COMPETING CONTINUATION	$249,000
														Subtotal = $249,000

Issue Date FY: 2018 ( Subtotal = $249,000 )
2018	2018	FLORIDA STATE UNIVERSITY	874 TRADITIONS WAY	TALLAHASSEE	FL	32306	LEON	USA	Aging Research	001	4	6/22/2018	NON-COMPETING CONTINUATION	$0
2018	2018	FLORIDA STATE UNIVERSITY	874 TRADITIONS WAY	TALLAHASSEE	FL	32306	LEON	USA	Aging Research	000	4	4/26/2018	NON-COMPETING CONTINUATION	$249,000
														Subtotal = $249,000

Issue Date FY: 2017 ( Subtotal = $310,434 )
2017	2017	FLORIDA STATE UNIVERSITY	874 TRADITIONS WAY	TALLAHASSEE	FL	32306	LEON	USA	Aging Research	001	3	8/15/2017	EXTENSION WITH OR WITHOUT FUNDS	$61,434
2017	2017	FLORIDA STATE UNIVERSITY, THE	874 TRADITIONS WAY	TALLAHASSEE	FL	32306	LEON	USA	Aging Research	000	3	5/11/2017	EXTENSION WITH OR WITHOUT FUNDS	$249,000
														Subtotal = $310,434

Grand Total All Awards = $808,099

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Parietal-hippocampal network in the triple transgenic mouse model of Alzheimers

Award Number: R00AG049090

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2016

PERIOD OF PERFORMANCE END DATE: 04/30/2021

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer