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Longitudinal Analysis of Diffusion Tensor Imaging to Discover Adolescent Alcohol Use Effect

Award Number: R00AA028840
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/10/2021
PERIOD OF PERFORMANCE END DATE: 12/31/2026

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Longitudinal Analysis of Diffusion Tensor Imaging to Discover Adolescent Alcohol Use Effect - Longitudinal Analysis of Diffusion Tensor Imaging to Discover Adolescent Alcohol Use Effect PROJECT ABSTRACT Alcohol abuse is the third leading preventable cause of death in the United States. A signature injury of Alcohol Use Disorder (AUD) is in the white-matter (WM) microstructure and its constituents, which enable connectivity of proximal and distal brain structures and functional integration. Despite the progress in understanding alcohol’s effects in adults, still unclear is the causal direction between abnormal WM maturation and initiation of heavy yet non-dependent drinking during adolescence. To gain insight into regional development of connectivity, the National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA), a prospective longitudinal study of 831 youth to track normal and alcohol-related deviant neurodevelopmental trajectories, acquired diffusion tensor imaging (DTI) data annually. Unraveling alcohol effects from the complex dynamic course of adolescent neurodevelopment requires highly sensitive analysis approaches. In this project, I propose a new type of longitudinal DTI analysis, in which a unified trajectory model is used both for explicitly capturing biologically-plausible variation in DTI measurements across visits within each subject and for estimating a group-level developmental trajectory. Such an approach will result in longitudinally consistent DTI measurements enabling accurate characterization of microstructural development in normal adolescents. Based on this approach, I will test the hypothesis that precursors of drinking onset and the disruption effects induced by initiation of alcohol use are related to different brain regions. The analysis will identify the precursors by comparing developmental trajectories prior to drinking onset between the no-to-low and heavy drinking cohorts and will identify the disruption by comparing trajectories after drinking onset. The alcohol- induced disruption to WM maturation will be further stratified with respect to age, highlighting the heightened vulnerability in younger adolescents. Lastly, the proposed longitudinal analysis also facilitates further tracking of microstructural remodeling following abstinence to identify reversible or persistent alcohol-related injury. Revealed imaging phenotypes linked to adolescent heavy drinking could point to potential causes and precursors of AUD, which could in turn improve diagnosis and prevention in clinical settings. Moreover, researchers will be able to use the proposed longitudinal approach as a general tool to answer their neuroscientific questions in the context of seeking developmental change.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $248,999 )
2026	2026	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Alcohol Research Programs	000	5	4/10/2026	NON-COMPETING CONTINUATION	$248,999
														Subtotal = $248,999

Issue Date FY: 2025 ( Subtotal = $248,999 )
2025	2025	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Alcohol Research Programs	000	4	12/24/2024	NON-COMPETING CONTINUATION	$224,098
2025	2025	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Alcohol Research Programs	001	4	8/14/2025	NON-COMPETING CONTINUATION	$24,901
														Subtotal = $248,999

Issue Date FY: 2024 ( Subtotal = $292,358 )
2024	2024	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Alcohol Research Programs	000	3	1/17/2024	EXTENSION WITH OR WITHOUT FUNDS	$248,999
2024	2024	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Alcohol Research Programs	001	3	4/3/2024	EXTENSION WITH OR WITHOUT FUNDS	$43,359
2024	2024	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Alcohol Research Programs	002	3	6/12/2024	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $292,358

Grand Total All Awards = $790,356

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Longitudinal Analysis of Diffusion Tensor Imaging to Discover Adolescent Alcohol Use Effect

Award Number: R00AA028840

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/10/2021

PERIOD OF PERFORMANCE END DATE: 12/31/2026

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