Monday, June 30, 2025 6/30/2025

Alcohol-related sleep disturbances and circuit dynamics of arousal neuropeptides

Award Number: R00AA025677
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2021
PERIOD OF PERFORMANCE END DATE: 05/31/2024

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Alcohol-related sleep disturbances and circuit dynamics of arousal neuropeptides - Project Summary Alcoholism is a chronic disorder with severe consequences to physiology of affected individuals, and far- reaching effects on society in general. In particular, further research is required to advance scientific knowledge of the intricate neurobiology underlying the relationship between excessive alcohol drinking and deficits in sleep, a fundamental component of life. This proposal will integrate in vivo measurements of neural calcium activity with electroencephalogram sleep recordings in animal models of long-term, free-choice intermittent heavy alcohol exposure, in order to establish (or refute) causal relationships between the hypothalamic hypocretin system, extended amygdala corticotropin-releasing factor system, and stress-like states of hyperarousal (disrupted sleep) during alcohol withdrawal. Knowledge gained from the proposed experiments will inform future strategies for mitigation of drug abuse and relapse.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Alcohol Research Programs	000	5	10/11/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $31,905 )
2024	2021	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Alcohol Research Programs	000	3	8/20/2024	EXTENSION WITH OR WITHOUT FUNDS	$31,905
														Subtotal = $31,905

Issue Date FY: 2023 ( Subtotal = $331,578 )
2023	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Alcohol Research Programs	000	5	5/30/2023	NON-COMPETING CONTINUATION	$238,448
2023	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Alcohol Research Programs	001	5	5/31/2023	SUPPLEMENT FOR EXPANSION	$93,130
														Subtotal = $331,578

Issue Date FY: 2022 ( Subtotal = $334,589 )
2022	2022	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Alcohol Research Programs	001	4	8/27/2022	SUPPLEMENT FOR EXPANSION	$90,253
2022	2022	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Alcohol Research Programs	000	4	5/26/2022	NON-COMPETING CONTINUATION	$244,336
														Subtotal = $334,589

Issue Date FY: 2021 ( Subtotal = $249,000 )
2021	2021	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Alcohol Research Programs	000	3	5/13/2021	EXTENSION WITH OR WITHOUT FUNDS	$249,000
														Subtotal = $249,000

Grand Total All Awards = $947,072

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Alcohol-related sleep disturbances and circuit dynamics of arousal neuropeptides

Award Number: R00AA025677

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2021

PERIOD OF PERFORMANCE END DATE: 05/31/2024

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