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Center on Genetic Determinants of Alcohol Ingestion and Responses to Alcohol

Award Number: P60AA007611
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/01/1989
PERIOD OF PERFORMANCE END DATE: 11/30/2027

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Center on Genetic Determinants of Alcohol Ingestion and Responses to Alcohol - Project Summary/Abstract: Overall Indiana Alcohol Research Center (IARC) The Indiana Alcohol Research Center (IARC) has devoted more than three decades to understanding alcohol use disorder (AUD) risk using neuroscientific and behavioral genetic tools. This prior work leads us to study the heritable, neurobiological, and behavioral factors that drive binge and high-intensity drinking (BHID). Most research on BHID focuses on harm from numbers of drinks or level of alcohol exposure but does not account for “front-loading”— the initial rapid drinking to ostensibly enhance alcohol’s rate of change in the brain and its resulting effects. Although such drinking is initially more intoxicating, compensatory (neuro-) adaptations can create an acute tolerance to rewarding effects, which in turn induces a need to increase consumption. Judgments about the next drink can then be affected so as to sustain intake, pushing alcohol exposure into high-intensity levels. The long-term goal of the IARC is to deploy its multidisciplinary efforts to understand the heritable origins of responses to alcohol and development of AUD. The objective of this next IARC cycle is to study brain circuits and behaviors that influence both the rapid front-loading and sustained drinking behaviors that elevate alcohol concentration to hazardous, high-intensity levels. In studies of both humans and our selected, alcohol-preferring animals, our specific aims will be to: (1) Study human neural, perceptual, and subject factors that relate to: a) preferences for a steeper rise in alcohol concentration and b) acute tolerance to a sustained binge-level exposure; (2) Study heritable differences in the structure and function of frontal brain circuitry hypothesized to underlie front-loading, high drinking, and behavioral inhibition in rat lines selected for high alcohol intake; (3) Study heritable differences in insula circuits hypothesized to mediate front-loading and subsequent sustained high drinking in rat lines selected for high alcohol intake, as well as potential related contributors to high intensity drinking; and (4) Study how adaptation in glutamatergic input to the dorsomedial striatum from basolateral amygdala and insula contributes to alcohol tolerance, driving a) sustained high-intensity drinking in the high-consuming cHAP mouse line, and b) binge-like drinking in the C56BL/6J inbred mouse strain. These projects are supported by service cores to (5) provide selected lines of alcohol-preferring and animals and (6) conduct higher-level network-analyses and computational modeling of results from the research components. (7) A Pilot Core assists new investigators to alcohol research and explores new ideas, while (8) an Information and Dissemination Core educates and advises the community, schools, healthcare providers, and state policy makers about both BHID and AUD. The IARC thus functions in a coordinated way to integrate human and animal research, and to determine how heritable risk and alcohol exposure contribute to BHID.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,727,265 )
2025	2025	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	000	38	11/27/2024	NON-COMPETING CONTINUATION	$1,727,265
														Subtotal = $1,727,265

Issue Date FY: 2024 ( Subtotal = $1,756,278 )
2024	2024	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	000	37	11/27/2023	NON-COMPETING CONTINUATION	$1,756,278
														Subtotal = $1,756,278

Issue Date FY: 2023 ( Subtotal = $1,786,244 )
2023	2023	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	004	36	9/25/2023	COMPETING CONTINUATION	$0
2023	2023	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	003	36	6/13/2023	COMPETING CONTINUATION	$546,694
2023	2023	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	001	36	12/28/2022	COMPETING CONTINUATION	$1,786,244
2023	2022	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	002	35	6/13/2023	NON-COMPETING CONTINUATION	-$546,694
2023	2022	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	000	35	12/21/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,786,244

Issue Date FY: 2022 ( Subtotal = $1,622,897 )
2022	2022	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	000	35	12/17/2021	NON-COMPETING CONTINUATION	$1,460,606
2022	2022	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	001	35	6/22/2022	NON-COMPETING CONTINUATION	$162,291
														Subtotal = $1,622,897

Issue Date FY: 2021 ( Subtotal = $1,663,064 )
2021	2021	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	001	34	2/23/2021	NON-COMPETING CONTINUATION	$166,307
2021	2021	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	000	34	12/1/2020	NON-COMPETING CONTINUATION	$1,496,757
														Subtotal = $1,663,064

Issue Date FY: 2020 ( Subtotal = $1,679,125 )
2020	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	000	33	11/29/2019	NON-COMPETING CONTINUATION	$1,679,125
														Subtotal = $1,679,125

Issue Date FY: 2019 ( Subtotal = $1,751,605 )
2019	2019	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	000	32	11/26/2018	NON-COMPETING CONTINUATION	$1,751,605
2019	2019	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	001	32	9/27/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,751,605

Issue Date FY: 2018 ( Subtotal = $1,787,927 )
2018	2018	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	002	31	2/26/2018	COMPETING CONTINUATION	$202,968
2018	2018	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	007	31	8/9/2018	COMPETING CONTINUATION	$0
2018	2018	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	000	31	12/11/2017	COMPETING CONTINUATION	$1,787,927
2018	2018	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	004	31	3/15/2018	COMPETING CONTINUATION	$319
2018	2018	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	006	31	4/20/2018	COMPETING CONTINUATION	$7,189
2018	2017	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	005	30	4/20/2018	NON-COMPETING CONTINUATION	-$7,189
2018	2017	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	003	30	3/15/2018	NON-COMPETING CONTINUATION	-$319
2018	2017	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	001	30	2/26/2018	NON-COMPETING CONTINUATION	-$202,968
														Subtotal = $1,787,927

Issue Date FY: 2017 ( Subtotal = $1,681,649 )
2017	2017	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	000	30	12/1/2016	NON-COMPETING CONTINUATION	$1,508,832
2017	2017	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	006	30	7/27/2017	NON-COMPETING CONTINUATION	$167,648
2017	2016	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	004	29	4/10/2017	EXTENSION WITH OR WITHOUT FUNDS	$5,169
2017	2016	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	005	29	4/10/2017	EXTENSION WITH OR WITHOUT FUNDS	$5,169
2017	2016	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	002	29	3/8/2017	EXTENSION WITH OR WITHOUT FUNDS	$263
2017	2015	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	003	28	4/10/2017	NON-COMPETING CONTINUATION	-$5,169
2017	2015	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	001	28	3/8/2017	NON-COMPETING CONTINUATION	-$263
														Subtotal = $1,681,649

Issue Date FY: 2016 ( Subtotal = $1,702,587 )
2016	2016	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	001	29	12/1/2015	EXTENSION WITH OR WITHOUT FUNDS	$1,532,329
2016	2016	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	002	29	2/3/2016	EXTENSION WITH OR WITHOUT FUNDS	$170,259
2016	2015	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	000	28	10/21/2015	NON-COMPETING CONTINUATION	-$1
														Subtotal = $1,702,587

Issue Date FY: 2015 ( Subtotal = $1,679,788 )
2015	2015	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	001	28	1/28/2015	NON-COMPETING CONTINUATION	$121,222
2015	2015	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	002	28	5/14/2015	NON-COMPETING CONTINUATION	$1
2015	2015	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	000	28	12/18/2014	NON-COMPETING CONTINUATION	$1,558,565
														Subtotal = $1,679,788

Issue Date FY: 2014 ( Subtotal = $1,713,802 )
2014	2014	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	001	27	3/5/2014	NON-COMPETING CONTINUATION	$123,674
2014	2014	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	000	27	12/1/2013	NON-COMPETING CONTINUATION	$1,590,128
														Subtotal = $1,713,802

Issue Date FY: 2013 ( Subtotal = $1,797,423 ) (Continued on the next page)
Grand Total All Awards = $42,141,768

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Center on Genetic Determinants of Alcohol Ingestion and Responses to Alcohol

Award Number: P60AA007611

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/01/1989

PERIOD OF PERFORMANCE END DATE: 11/30/2027

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