Monday, May 16, 2022 5/16/2022

Center on Genetic Determinants of Alcohol Ingestion and Responses to Alcohol

Award Number: P60AA007611
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary: Overall Indiana Alcohol Research Center (IARC) The Indiana Alcohol Research Center (IARC) has devoted three decades to understanding how genetic factors and responses to alcohol contribute to the risk of developing an alcohol use disorder (AUD). We continue these efforts by now examining why certain immoderate drinkers transition into a stage in which they become insensitive to the aversive outcomes associated with heavy drinking. The IARC will therefore address the critical need to understand the genetic, behavioral, and neurobiological paths by which “aversion-resistant drinking” develops. The rationale for our centered approach is that working in close association across several scientific disciplines and spheres of expertise permits our investigators to achieve insights that are not possible when working in isolation. The IARC's central hypothesis is that aversion-resistant drinking arises through a combination of inherited behavioral and neurobiological vulnerabilities, as well as progressive changes in fronto-striatal neurotransmission in response to drinking history. The objective of this next IARC cycle is to therefore apply coordinated, multi-disciplinary efforts to understand the brain and behavioral mechanisms through which aversion-resistant drinking arises. Using the IARC's selected animal lines, our specific aims are to determine how aversion resistant drinking may arise through: (1) Changes in medial prefrontal glutamate systems, (2) unique impulsive endophenotypic behaviors and associated differential functioning in medial prefrontal cortex, (3) forms of cognitive inflexibility and alterations in glutamate receptors in the brain's dorsal striatum, and (4) drinking history and genetic influences on the corticostriatal encoding of alcohol-paired cues. Accompanying these preclinical animal studies will be (5) a novel translational paradigm in humans to determine how aversion-resistant alcohol seeking behaviors relate to drinking history, alcohol use disorder symptoms, and brain physiology. The IARC will also (6) provide a pilot mechanism to develop new investigators and research directions, and support promising directions related to the IARC's research components. Finally, the IARC will expand existing educational, implementation, and outreach for primary care providers and the legal profession. The IARC will thus function in a coordinated way to integrate human and animal research on how genetic risk, alcohol exposure, and endophenotypic behaviors contribute to the important problem of compulsive drinking.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $1,460,606 )
2022	2022	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	000	35	12/17/2021	NON-COMPETING CONTINUATION	$1,460,606


Issue Date FY: 2021 ( Subtotal = $1,663,064 )
2021	2021	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	001	34	2/23/2021	NON-COMPETING CONTINUATION	$166,307
2021	2021	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	000	34	12/1/2020	NON-COMPETING CONTINUATION	$1,496,757


Issue Date FY: 2020 ( Subtotal = $1,679,125 )
2020	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	000	33	11/29/2019	NON-COMPETING CONTINUATION	$1,679,125


Issue Date FY: 2019 ( Subtotal = $1,751,605 )
2019	2019	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	001	32	9/27/2019	NON-COMPETING CONTINUATION	$0
2019	2019	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	000	32	11/26/2018	NON-COMPETING CONTINUATION	$1,751,605


Issue Date FY: 2018 ( Subtotal = $1,787,927 )
2018	2018	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	000	31	12/11/2017	COMPETING CONTINUATION	$1,787,927
2018	2018	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	006	31	4/20/2018	COMPETING CONTINUATION	$7,189
2018	2018	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	004	31	3/15/2018	COMPETING CONTINUATION	$319
2018	2018	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	007	31	8/9/2018	COMPETING CONTINUATION	$0
2018	2018	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	002	31	2/26/2018	COMPETING CONTINUATION	$202,968
2018	2017	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	005	30	4/20/2018	NON-COMPETING CONTINUATION	-$7,189
2018	2017	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	001	30	2/26/2018	NON-COMPETING CONTINUATION	-$202,968
2018	2017	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	003	30	3/15/2018	NON-COMPETING CONTINUATION	-$319


Issue Date FY: 2017 ( Subtotal = $1,681,649 )
2017	2017	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	000	30	12/1/2016	NON-COMPETING CONTINUATION	$1,508,832
2017	2017	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	006	30	7/27/2017	NON-COMPETING CONTINUATION	$167,648
2017	2016	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	002	29	3/8/2017	EXTENSION WITH OR WITHOUT FUNDS	$263
2017	2016	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	004	29	4/10/2017	EXTENSION WITH OR WITHOUT FUNDS	$5,169
2017	2016	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	005	29	4/10/2017	EXTENSION WITH OR WITHOUT FUNDS	$5,169
2017	2015	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	001	28	3/8/2017	NON-COMPETING CONTINUATION	-$263
2017	2015	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	003	28	4/10/2017	NON-COMPETING CONTINUATION	-$5,169


Issue Date FY: 2016 ( Subtotal = $1,702,587 )
2016	2016	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	002	29	2/3/2016	EXTENSION WITH OR WITHOUT FUNDS	$170,259
2016	2016	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	001	29	12/1/2015	EXTENSION WITH OR WITHOUT FUNDS	$1,532,329
2016	2015	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	000	28	10/21/2015	NON-COMPETING CONTINUATION	-$1


Issue Date FY: 2015 ( Subtotal = $1,679,788 )
2015	2015	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	000	28	12/18/2014	NON-COMPETING CONTINUATION	$1,558,565
2015	2015	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	001	28	1/28/2015	NON-COMPETING CONTINUATION	$121,222
2015	2015	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	002	28	5/14/2015	NON-COMPETING CONTINUATION	$1


Issue Date FY: 2014 ( Subtotal = $1,713,802 )
2014	2014	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	001	27	3/5/2014	NON-COMPETING CONTINUATION	$123,674
2014	2014	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	000	27	12/1/2013	NON-COMPETING CONTINUATION	$1,590,128


Issue Date FY: 2013 ( Subtotal = $1,797,423 )
2013	2013	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	000	26	12/24/2012	COMPETING CONTINUATION	$1,797,423


Issue Date FY: 2012 ( Subtotal = $1,667,612 )
2012	2012	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	000	25	11/16/2011	NON-COMPETING CONTINUATION	$1,530,694
2012	2012	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	001	25	6/1/2012	NON-COMPETING CONTINUATION	$136,918


Issue Date FY: 2011 ( Subtotal = $1,719,376 )
2011	2011	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	001	24	7/6/2011	NON-COMPETING CONTINUATION	$109,415
2011	2011	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	000	24	11/30/2010	NON-COMPETING CONTINUATION	$1,609,961


Issue Date FY: 2010 ( Subtotal = $1,792,590 )
2010	2010	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	001	23	3/8/2010	NON-COMPETING CONTINUATION	$0
2010	2010	INDIANA UNIVERSITY, BLOOMINGTON	509 EAST 3RD STREET	BLOOMINGTON	IN	47405	MONROE	USA	Alcohol Research Programs	000	23	1/21/2010	NON-COMPETING CONTINUATION	$1,792,590


Issue Date FY: 2009 ( Subtotal = $1,943,591 ) (Continued on the next page)
Grand Total All Awards = $36,709,690

Sum of Action Amount is $36,709,690;

Grand Total = $36,709,690

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Center on Genetic Determinants of Alcohol Ingestion and Responses to Alcohol

Award Number: P60AA007611

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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