Thursday, September 21, 2023 9/21/2023

The Southwest National Primate Research Center: Rhesus Macaque Expansion

Award Number: P51OD011133
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Abstract The Southwest National Primate Research Center (SNPRC) houses a Specific Pathogen Free (SPF) rhesus macaque colony of Indian origin (Ind RM), supported by the NIH SPF rhesus breeding program (U42OD010442). This colony of approximately 800 animals supports AIDS-related research both at SNPRC and through sales to AIDS investigators at other institutions. However, there is a major national shortage of research nonhuman primates (NHPs), and particularly of SPF Ind RM. This has severely impacted our ability to support the national research mission of HIV/AIDS as well as in the area of non-AIDS/other infectious diseases, AIDS co-infections, malaria, TB, COVID-19, etc. The NIH has recognized this need for expansion of SPF rhesus production and strongly recommends increasing Ind RM breeding capacity. The SNPRC is well positioned to expand its SPF Ind RM production as a center located in a climate hospitable to largely outdoor housing at an institution with capacity for expansion. Our host institution Texas Biomed has recently raised funds to build a large new NHP facility which could house ~ 800 NHPs. Texas Biomed/SNPRC also been funded by the NIH/ORIP to expand our production capacity by 40% over our existing capacity via a C06. Finally, through Texas Biomed support, we have procured ~ 150 conventional founder/breeder Ind RM (conventional). As such the SNPRC Ind RM population can increase to 1600-2000 in the next five years. However, we request specific support for this expansion to happen, including more personnel and consumables support in the next three-to-four years while our colony is growing, and additional caging. We will also have added behavioral, breeding colony and viral testing requirements. As part of this multiyear administrative supplement to the SNPRC base grant (P51OD011133-24, -25 and -26, PI, Schlesinger S, PD, Kaushal D), we propose to increase the size of the SNPRC SPF Ind RM colony from 800 in 2021 to 1600-2000 by the year 2026. These funds will be used to augment strong institutional support as part of the following specific aims.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $10,490,304 )
2023	2023	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Research Infrastructure Programs	001	25	4/20/2023	NON-COMPETING CONTINUATION	$7,483,557
2023	2023	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Research Infrastructure Programs	002	25	5/1/2023	SUPPLEMENT FOR EXPANSION	$73,260
2023	2023	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Allergy and Infectious Diseases Research	004	25	5/31/2023	SUPPLEMENT FOR EXPANSION	$1,943,312
2023	2023	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Research Infrastructure Programs	005	25	7/6/2023	SUPPLEMENT FOR EXPANSION	$490,176
2023	2023	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Research Infrastructure Programs	003	25	5/2/2023	SUPPLEMENT FOR EXPANSION	$499,999
2023	2022	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Research Infrastructure Programs	000	24	11/8/2022	NON-COMPETING CONTINUATION	$0


Issue Date FY: 2022 ( Subtotal = $11,233,312 )
2022	2022	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Research Infrastructure Programs	012	24	8/16/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2022	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Research Infrastructure Programs	009	24	7/13/2022	SUPPLEMENT FOR EXPANSION	$73,260
2022	2022	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Research Infrastructure Programs	010	24	8/1/2022	SUPPLEMENT FOR EXPANSION	$499,944
2022	2022	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Allergy and Infectious Diseases Research	008	24	6/6/2022	SUPPLEMENT FOR EXPANSION	$2,256,688
2022	2022	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Research Infrastructure Programs	007	24	6/1/2022	SUPPLEMENT FOR EXPANSION	$419,864
2022	2022	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Research Infrastructure Programs	011	24	8/3/2022	SUPPLEMENT FOR EXPANSION	$499,999
2022	2022	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Research Infrastructure Programs	005	24	4/29/2022	NON-COMPETING CONTINUATION	$7,483,557
2022	2021	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Research Infrastructure Programs	003	23	10/23/2021	COMPETING CONTINUATION	$339,501
2022	2021	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Research Infrastructure Programs	004	23	11/3/2021	COMPETING CONTINUATION	$0
2022	2021	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Allergy and Infectious Diseases Research	001	23	10/23/2021	SUPPLEMENT FOR EXPANSION	$174,166
2022	2021	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Allergy and Infectious Diseases Research	006	23	6/1/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2020	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Research Infrastructure Programs	002	22	10/23/2021	SUPPLEMENT FOR EXPANSION	-$339,501
2022	2020	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Allergy and Infectious Diseases Research	000	22	10/23/2021	SUPPLEMENT FOR EXPANSION	-$174,166


Issue Date FY: 2021 ( Subtotal = $8,877,641 )
2021	2021	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Research Infrastructure Programs	003	23	7/1/2021	SUPPLEMENT FOR EXPANSION	$499,742
2021	2021	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Research Infrastructure Programs	001	23	5/11/2021	COMPETING CONTINUATION	$7,483,557
2021	2021	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Allergy and Infectious Diseases Research	002	23	5/18/2021	SUPPLEMENT FOR EXPANSION	$894,342
2021	2020	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Research Infrastructure Programs	000	22	1/23/2021	NON-COMPETING CONTINUATION	$0


Issue Date FY: 2020 ( Subtotal = $10,922,350 )
2020	2020	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Research Infrastructure Programs	001	22	7/1/2020	SUPPLEMENT FOR EXPANSION	$499,999
2020	2020	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Research Infrastructure Programs	000	22	4/30/2020	NON-COMPETING CONTINUATION	$7,939,355
2020	2020	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Research Infrastructure Programs	002	22	7/24/2020	SUPPLEMENT FOR EXPANSION	$482,996
2020	2020	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Allergy and Infectious Diseases Research	003	22	8/21/2020	SUPPLEMENT FOR EXPANSION	$2,000,000


Issue Date FY: 2019 ( Subtotal = $9,362,949 )
2019	2019	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Research Infrastructure Programs	003	21	6/11/2019	SUPPLEMENT FOR EXPANSION	$499,998
2019	2019	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Research Infrastructure Programs	002	21	5/4/2019	NON-COMPETING CONTINUATION	$7,939,355
2019	2019	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Research Infrastructure Programs	005	21	8/29/2019	SUPPLEMENT FOR EXPANSION	$499,999
2019	2019	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Research Infrastructure Programs	006	21	9/18/2019	NON-COMPETING CONTINUATION	$0
2019	2019	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Research Infrastructure Programs	004	21	7/27/2019	SUPPLEMENT FOR EXPANSION	$423,597
2019	2018	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Research Infrastructure Programs	001	20	2/22/2019	NON-COMPETING CONTINUATION	$0
2019	2018	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Research Infrastructure Programs	000	20	11/8/2018	SUPPLEMENT FOR EXPANSION	$0


Issue Date FY: 2018 ( Subtotal = $8,810,408 )
2018	2018	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Research Infrastructure Programs	001	20	8/31/2018	SUPPLEMENT FOR EXPANSION	$410,903
2018	2018	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Research Infrastructure Programs	002	20	9/1/2018	SUPPLEMENT FOR EXPANSION	$460,148
2018	2018	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Research Infrastructure Programs	000	20	6/18/2018	NON-COMPETING CONTINUATION	$7,939,357


Issue Date FY: 2017 ( Subtotal = $7,542,375 )
2017	2017	TEXAS BIOMEDICAL RESEARCH INSTITUTE	7620 NW LOOP 410	SAN ANTONIO	TX	78227	BEXAR	USA	Research Infrastructure Programs	000	19	7/18/2017	NON-COMPETING CONTINUATION	$7,542,375


Issue Date FY: 2016 ( Subtotal = $8,379,501 )
2016	2016	TEXAS BIOMEDICAL RESEARCH INSTITUTE	7620 NORTHWEST LOOP 410	SAN ANTONIO	TX	78227	BEXAR	USA	Trans-NIH Research Support	001	18	7/20/2016	SUPPLEMENT FOR EXPANSION	$401,280
2016	2016	TEXAS BIOMEDICAL RESEARCH INSTITUTE	7620 NORTHWEST LOOP 410	SAN ANTONIO	TX	78227	BEXAR	USA	Research Infrastructure Programs	000	18	5/18/2016	COMPETING CONTINUATION	$7,978,221


Issue Date FY: 2015 ( Subtotal = $8,126,678 ) (Continued on the next page)
2015	2015	TEXAS BIOMEDICAL RESEARCH INSTITUTE	7620 NORTHWEST LOOP 410	SAN ANTONIO	TX	78227	BEXAR	USA	Research Infrastructure Programs	000	17	4/30/2015	NON-COMPETING CONTINUATION	$7,367,413
Grand Total All Awards = $106,771,223

Sum of Action Amount is $106,771,223;

Grand Total = $106,771,223

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The Southwest National Primate Research Center: Rhesus Macaque Expansion

Award Number: P51OD011133

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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