Tuesday, October 3, 2023 10/3/2023

California National Primate Research Center

Award Number: P51OD011107
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

View Award Abstract

Summary The COVID-19 pandemic constitutes a significant challenge to health care systems in the United States and abroad. A systemic compromise of the organism following SARS-CoV-2 infection has emerged as an important factor associated with COVID-19 severity, disproportionally affecting older patients with comorbidities such as hypertension, diabetes, and dementia. In addition to respiratory symptoms, COVID-19 patients can present neurological symptoms, ranging from the frequent loss of smell to rare but severe neurovascular and neuroinflammatory events. These neurological symptoms disproportionally affect patients with Alzheimer’s disease (AD) and can potentially lead to clinical scenarios previously associated with faster neurodegenerative progression and worse behavioral outcomes. The involvement of the brain during COVID-19 and the mechanisms of interaction between SARS-CoV-2 and AD pathological routes, however, remain poorly understood. Our long-term goal in this project is to further our knowledge on how neuropathology may contribute to the complex clinical presentation of COVID-19 and how SARS-CoV-2 infection and AD can negatively synergize in vulnerable patients. The objective of this grant is to characterize the short-term effects of SARS- CoV-2 in the brain during the acute stage of the infection in both young and aged diabetic animals, and a possible protective effect of immunotherapeutic prophylaxis. The central hypothesis is that SARS-CoV-2 is both neuroinvasive and neurotropic, accessing the brain and infecting neurons and potentially other cells within the CNS, leading to neurodegeneration, inflammation, and a brain environment conducive to dementia. The rationale is that other human coronaviruses are neuroinvasive and neurotropic, including the closely related SARS-CoV- 1, causing direct damage to neurons and myelin and triggering neuroinflammatory processes. Furthermore, the SARS-CoV-2 entry receptor ACE2 has been previously implicated in AD, and other coronavirus infections have been reported to trigger adaptive intracellular cascades linked to neurodegeneration. Our specific aims will test the following hypotheses: (Aim 1) SARS-CoV-2 is neuroinvasive, neurotropic, and its infection of brain cells causes neuronal and myelinic damage; (Aim 2) SARS-CoV-2 infection triggers neuroinflammation and cytokine release, and prophylactic treatment with immunotherapeutic agents, such as convalescent plasma and monoclonal antibodies, can affect the brain response; (Aim 3) COVID-19 and AD neuropathological routes interact directly at the molecular level through the regulation of ACE2 and stress response pathways. This contribution is significant as it will considerably advance our knowledge of COVID-19 pathology, opening new avenues of treatment and care for a major public health concern, while also providing the necessary framework to understand the long-term consequences of COVID-19 and its impact on AD pathology. The proposed research is innovative in its use of a highly translational non-human primate model to reveal the neurobiological aspects of viral infections.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $15,481,276 )
2023	2023	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	004	62	7/26/2023	SUPPLEMENT FOR EXPANSION	$499,999
2023	2023	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	002	62	5/3/2023	COMPETING CONTINUATION	$11,857,934
2023	2023	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Allergy and Infectious Diseases Research	003	62	5/31/2023	SUPPLEMENT FOR EXPANSION	$3,069,950
2023	2023	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	005	62	8/8/2023	SUPPLEMENT FOR EXPANSION	$53,393
2023	2023	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	006	62	9/7/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	61	3/9/2023	NON-COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	61	2/10/2023	NON-COMPETING CONTINUATION	$0


Issue Date FY: 2022 ( Subtotal = $15,567,288 )
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Allergy and Infectious Diseases Research	003	61	6/14/2022	SUPPLEMENT FOR EXPANSION	$1,599,566
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	61	5/5/2022	NON-COMPETING CONTINUATION	$12,623,145
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	006	61	8/16/2022	SUPPLEMENT FOR EXPANSION	$485,114
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	005	61	7/30/2022	SUPPLEMENT FOR EXPANSION	$499,919
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	002	61	6/1/2022	SUPPLEMENT FOR EXPANSION	$297,763
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	61	5/28/2022	SUPPLEMENT FOR EXPANSION	$61,781
2022	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Allergy and Infectious Diseases Research	004	59	7/20/2022	SUPPLEMENT FOR EXPANSION	$0


Issue Date FY: 2021 ( Subtotal = $14,929,130 )
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Allergy and Infectious Diseases Research	001	59	2/12/2021	SUPPLEMENT FOR EXPANSION	$40,119
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	004	60	7/1/2021	SUPPLEMENT FOR EXPANSION	$498,994
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	005	60	7/31/2021	SUPPLEMENT FOR EXPANSION	$247,234
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	007	60	9/8/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Allergy and Infectious Diseases Research	003	60	5/18/2021	SUPPLEMENT FOR EXPANSION	$1,459,457
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	006	60	9/2/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	002	60	5/11/2021	NON-COMPETING CONTINUATION	$12,683,326
2021	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	59	12/22/2020	NON-COMPETING CONTINUATION	$0


Issue Date FY: 2020 ( Subtotal = $16,303,404 )
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	013	59	9/23/2020	SUPPLEMENT FOR EXPANSION	$0
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Allergy and Infectious Diseases Research	011	59	8/18/2020	SUPPLEMENT FOR EXPANSION	$0
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Allergy and Infectious Diseases Research	012	59	8/19/2020	SUPPLEMENT FOR EXPANSION	$0
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	007	59	7/29/2020	SUPPLEMENT FOR EXPANSION	$499,000
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	002	59	4/30/2020	SUPPLEMENT FOR EXPANSION	$499,400
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	003	59	5/5/2020	SUPPLEMENT FOR EXPANSION	$67,485
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	010	59	8/17/2020	SUPPLEMENT FOR EXPANSION	$785,367
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Allergy and Infectious Diseases Research	008	59	7/31/2020	SUPPLEMENT FOR EXPANSION	$1,063,435
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	59	4/28/2020	NON-COMPETING CONTINUATION	$11,460,599
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	006	59	6/4/2020	SUPPLEMENT FOR EXPANSION	$435,918
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	005	59	5/16/2020	NON-COMPETING CONTINUATION	$0
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Allergy and Infectious Diseases Research	009	59	8/1/2020	SUPPLEMENT FOR EXPANSION	$1,492,200
2020	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	004	58	5/13/2020	NON-COMPETING CONTINUATION	$0
2020	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	58	2/29/2020	NON-COMPETING CONTINUATION	$0


Issue Date FY: 2019 ( Subtotal = $12,836,944 ) (Continued on the next page)
2019	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	006	58	5/23/2019	NON-COMPETING CONTINUATION	$11,401,866
2019	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	007	58	8/26/2019	SUPPLEMENT FOR EXPANSION	$499,926
2019	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	010	58	9/10/2019	SUPPLEMENT FOR EXPANSION	$499,999
2019	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	009	58	9/6/2019	SUPPLEMENT FOR EXPANSION	$41,590
2019	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	008	58	8/31/2019	SUPPLEMENT FOR EXPANSION	$393,563
2019	2018	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	000	57	10/31/2018	COMPETING CONTINUATION	$0
2019	2018	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	001	57	11/1/2018	SUPPLEMENT FOR EXPANSION	$0
2019	2018	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	002	57	11/2/2018	SUPPLEMENT FOR EXPANSION	$0
2019	2018	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Research Infrastructure Programs	005	57	4/19/2019	COMPETING CONTINUATION	$847,419
Grand Total All Awards = $155,058,906

Sum of Action Amount is $155,058,906;

Grand Total = $155,058,906

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California National Primate Research Center

Award Number: P51OD011107

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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