Wednesday, January 28, 2026 1/28/2026

Optimizing and Personalizing interventions for schizophrenia Across the Lifespan (OPAL)

Award Number: P50MH115843
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2018
PERIOD OF PERFORMANCE END DATE: 06/30/2030

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Optimizing and Personalizing interventions for schizophrenia Across the Lifespan (OPAL) - The OPAL Center is named after its goal of Optimizing and Personalizing interventions for people with schizophrenia Across the Lifespan. The target population for this ALACRITY Center is people diagnosed with schizophrenia, which typically affects individuals from adolescence or early adulthood until the end of life. Affected individuals commonly have impaired social and occupational functioning; experience persistent psychotic and mood symptoms; have cognitive problems that may progress; and are at risk for disability and premature death. Black, Indigenous, and People of Color (BIPOC) individuals are particularly at risk of poor outcomes. The goal of this renewal application is to extend our efforts to accelerate the development and implementation of effective, individualized treatments for schizophrenia in real clinical settings. The specific aims of the Center renewal application are as follows: 1. Strengthen our infrastructure that supports research that examines innovative ways to optimize treatments for people with schizophrenia throughout the lifespan and that accelerates the translation of clinical research on schizophrenia to routine practice settings. 2. Conduct projects that develop, adapt, and test innovative, accessible, and person-centered interventions that improve engagement in treatment and can be readily deployed. 3. Train scientists who will conduct translational research on interventions for schizophrenia. The OPAL Signature Project will use 16 years of data (2007-2022) from the Center for Medicaid and Medicare Services (CMS) to test hypotheses about risk factors for dementia among people diagnosed with schizophrenia and compare the effectiveness of treatment strategies after diagnosis of dementia. We will then integrate our findings to adapt a Cognitive Health Toolkit that provides assessment and management tools. Exploratory Project 1 tests a novel, person-centered approach to assessment and treatment initiation for BIPOC individuals with psychotic symptoms in community mental health clinics that incorporates an adapted version of the Cultural Formulation Interview to improve diagnosis and treatment engagement. Exploratory Project 2 will build on work done in Europe to adapt and test the feasibility and preliminary effectiveness of Flexible Assertive Community Treatment (ACT), which will allow ACT teams to allocate resources according to the individual needs of participants, improving efficiency and outcomes. Exploratory Project 3 uses mobile health (mHealth) technology to deliver measurement-based care and improve the person-centered outcomes of individuals with schizophrenia across the lifespan. OPAL projects use the Center's common resources and methodologies to improve implementation and personalization of treatments for important problems. Stakeholders help us to refine and adapt interventions for effective implementation in real-world settings.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2023	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	5	12/24/2025	COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	5	9/3/2025	COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	002	5	5/29/2024	COMPETING CONTINUATION	$0
2024	2023	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	001	5	3/22/2024	COMPETING CONTINUATION	$111,953
2024	2021	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	4	3/22/2024	NON-COMPETING CONTINUATION	-$111,953
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $2,090,847 )
2023	2023	RESEARCH FOUNDATION FOR MENTAL HYGIENE INC	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	002	5	8/7/2023	COMPETING CONTINUATION	$0
2023	2023	RESEARCH FOUNDATION FOR MENTAL HYGIENE INC	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	001	5	6/8/2023	COMPETING CONTINUATION	$2,090,847
2023	2021	RESEARCH FOUNDATION FOR MENTAL HYGIENE INC	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	4	1/18/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,090,847

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	RESEARCH FOUNDATION FOR MENTAL HYGIENE INC	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	4	2/8/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $1,031,393 )
2021	2021	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	001	4	7/12/2021	NON-COMPETING CONTINUATION	$0
2021	2021	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	4	12/24/2020	NON-COMPETING CONTINUATION	$1,031,393
														Subtotal = $1,031,393

Issue Date FY: 2020 ( Subtotal = $1,273,862 )
2020	2020	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	002	3	3/11/2020	NON-COMPETING CONTINUATION	$127,385
2020	2020	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	001	3	12/24/2019	NON-COMPETING CONTINUATION	$1,146,477
2020	2019	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	2	12/11/2019	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $1,273,862

Issue Date FY: 2019 ( Subtotal = $2,003,224 )
2019	2019	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	004	2	8/30/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2019	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	003	2	8/19/2019	SUPPLEMENT FOR EXPANSION	$278,509
2019	2019	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	2	12/20/2018	NON-COMPETING CONTINUATION	$1,344,163
2019	2019	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	001	2	4/29/2019	NON-COMPETING CONTINUATION	$0
2019	2019	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	002	2	8/1/2019	SUPPLEMENT FOR EXPANSION	$380,552
														Subtotal = $2,003,224

Issue Date FY: 2018 ( Subtotal = $2,100,414 )
2018	2018	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	1	3/13/2018	NEW	$1,566,707
2018	2018	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	001	1	5/23/2018	NEW	$533,707
														Subtotal = $2,100,414

Grand Total All Awards = $8,499,740

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Optimizing and Personalizing interventions for schizophrenia Across the Lifespan (OPAL)

Award Number: P50MH115843

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2018

PERIOD OF PERFORMANCE END DATE: 06/30/2030

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