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Epigenetic Mechanisms of Depression

Award Number: P50MH096890
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2012
PERIOD OF PERFORMANCE END DATE: 02/28/2022

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Epigenetic Mechanisms of Depression - PROJECT SUMMARY – OVERALL The objective of this Conte Center is to take maximal advantage of recent advances in chromatin biology, so- called epigenetics, to fundamentally increase our understanding of the long-lasting abnormalities in the brain that cause depression. Our work focuses on key limbic brain regions, such as nucleus accumbens and prefrontal cortex, which have been implicated directly in the control of mood in health and disease. The Center is composed of four Projects led by Eric Nestler (Mount Sinai), Schahram Akbarian (Mount Sinai), David Allis (Rockefeller), and Carol Tamminga (UT Southwestern), and two Scientific Cores—the Animal Models Core led by Venetia Zachariou (Mount Sinai) and Chromatin and Gene Analysis Core led by Li Shen (Mount Sinai). The PIs, along with several Co-PIs, are leaders in their fields who use their complementary expertise and approaches to execute a multidisciplinary program of research focused on transcriptional and chromatin abnormalities both in mouse models of depression and in postmortem brains of depressed humans. A defining feature of the Center is bidirectional translation, with findings from mice validated in humans, and with discoveries in humans put back into animal models to study underlying mechanisms. The Center's research is defined by four themes. First, we study a broad range of epigenetic mechanisms, including histone and DNA modifications, nucleosome turnover, and the 3D structure of chromatin, which work in concert to control gene transcription. This involves the use of several next generation sequencing methods and advanced bioinformatics to analyze the resulting complex datasets. Second, we use this insight to understand how exposure to stress early in life controls an individual's susceptibility vs. resilience to stress-related disorders for a lifetime through long-lasting epigenetic mechanisms. Third, we focus on sex differences in this epigenetic regulation, having defined shared as well as many distinct mechanisms operating in male vs. female brain. Fourth, these studies are identifying numerous key target genes and molecular pathways that are defining novel mechanisms underlying depression and other stress-related disorders, which will help drive the field toward improved treatments and diagnostic tests.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Mental Health Research Grants	000	10	10/24/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Mental Health Research Grants	000	10	6/2/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $2,000,000 )
2021	2021	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Mental Health Research Grants	000	10	2/24/2021	NON-COMPETING CONTINUATION	$2,000,000
														Subtotal = $2,000,000

Issue Date FY: 2020 ( Subtotal = $2,000,000 )
2020	2020	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Mental Health Research Grants	000	9	3/3/2020	NON-COMPETING CONTINUATION	$2,000,000
														Subtotal = $2,000,000

Issue Date FY: 2019 ( Subtotal = $2,000,000 )
2019	2019	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Mental Health Research Grants	000	8	2/21/2019	NON-COMPETING CONTINUATION	$2,000,000
														Subtotal = $2,000,000

Issue Date FY: 2018 ( Subtotal = $2,000,000 )
2018	2018	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Mental Health Research Grants	001	7	6/5/2018	NON-COMPETING CONTINUATION	$200,001
2018	2018	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Mental Health Research Grants	000	7	2/21/2018	NON-COMPETING CONTINUATION	$1,799,999
														Subtotal = $2,000,000

Issue Date FY: 2017 ( Subtotal = $2,000,000 )
2017	2017	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Mental Health Research Grants	000	6	3/13/2017	COMPETING CONTINUATION	$2,000,000
2017	2017	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Mental Health Research Grants	002	6	6/15/2017	COMPETING CONTINUATION	$18,929
2017	2016	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Mental Health Research Grants	001	5	6/15/2017	EXTENSION WITH OR WITHOUT FUNDS	-$18,929
														Subtotal = $2,000,000

Issue Date FY: 2016 ( Subtotal = $2,000,000 )
2016	2016	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL, BOX 3500	NEW YORK-NEW YORK	NY	10029		USA	Mental Health Research Grants	000	5	2/4/2016	EXTENSION WITH OR WITHOUT FUNDS	$2,000,000
														Subtotal = $2,000,000

Issue Date FY: 2015 ( Subtotal = $2,249,165 )
2015	2015	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL, BOX 3500	NEW YORK-NEW YORK	NY	10029		USA	Mental Health Research Grants	001	4	4/21/2015	NON-COMPETING CONTINUATION	$2,000,000
2015	2015	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL, BOX 3500	NEW YORK-NEW YORK	NY	10029		USA	Mental Health Research Grants	002	3	6/23/2015	SUPPLEMENT FOR EXPANSION	$0
2015	2015	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL, BOX 3500	NEW YORK-NEW YORK	NY	10029		USA	Mental Health Research Grants	000	3	2/26/2015	SUPPLEMENT FOR EXPANSION	$249,165
														Subtotal = $2,249,165

Issue Date FY: 2014 ( Subtotal = $2,014,238 )
2014	2014	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL, BOX 3500	NEW YORK-NEW YORK	NY	10029		USA	Mental Health Research Grants	000	3	4/21/2014	NON-COMPETING CONTINUATION	$2,000,000
2014	2014	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL, BOX 3500	NEW YORK-NEW YORK	NY	10029		USA	Mental Health Research Grants	001	3	6/9/2014	SUPPLEMENT FOR EXPANSION	$7,119
2014	2014	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL, BOX 3500	NEW YORK-NEW YORK	NY	10029		USA	Mental Health Research Grants	002	3	6/14/2014	SUPPLEMENT FOR EXPANSION	$7,119
														Subtotal = $2,014,238

Issue Date FY: 2013 ( Subtotal = $1,920,000 )
2013	2013	MT SINAI SCHOOL OF MEDICINE	1 GUSTAVE L LEVY PL, BOX 3500	NEW YORK-NEW YORK	NY	10029		USA	Mental Health Research Grants	000	2	6/5/2013	NON-COMPETING CONTINUATION	$1,920,000
														Subtotal = $1,920,000

Issue Date FY: 2012 ( Subtotal = $2,000,000 )
2012	2012	MT SINAI SCHOOL OF MEDICINE	1 GUSTAVE L LEVY PL, BOX 3500	NEW YORK-NEW YORK	NY	10029		USA	Mental Health Research Grants	000	1	4/23/2012	NEW	$2,000,000
														Subtotal = $2,000,000

Grand Total All Awards = $20,183,403

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Epigenetic Mechanisms of Depression

Award Number: P50MH096890

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2012

PERIOD OF PERFORMANCE END DATE: 02/28/2022

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