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Regulation of Cell Fate during Kidney Development and Disease

Award Number: P50DK096373
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/21/2012
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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Regulation of Cell Fate during Kidney Development and Disease - SUMMARY The overall goal of this “Pediatric Center of Excellence in Nephrology” is to provide a coordinated, interdisciplinary approach to study the development of the kidney vasculature during embryonic, fetal and postnatal life. The main theme of this Research Center is “Regulation of Cell Fate during Kidney Development and Disease.” Broadly, the proposed research deals with fundamental questions of clinical relevance in Pediatric Nephrology such as the understanding of the proper development, and the structural and functional maintenance of the kidney vasculature in health and disease. The experimental approaches range from examination of epigenetic mechanisms that control cell fate, plasticity, and identity and the cellular signals underlying the phenotypic transformation that occurs when homeostasis is threatened in early life. Project 1 will investigate the role of renin cell progenitors in the development and pathology of the kidney arterioles (R. Ariel Gomez and Maria Luisa Sequeira Lopez). Project 2 will define how the TGFb/FGF2 axis controls the fate of renin and vascular smooth muscle cells under conditions that threaten homeostasis in infancy (Patricio Ray, Agnes Swiatecka-Urban and Jennifer Charlton). Pilot and Feasibility projects within the general theme of the Center will be solicited at a national level from universities at large, the ASPN, the ASN and adult nephrology programs with the objective to add new talent to the investigation of renal diseases in children. This will be done in coordination with the other 2 PCENs to avoid overlap and guarantee the best outcome for each project. A cutting- edge Core in Single Cell Epigenomics, Transcriptomics and Bioinformatics (Nathan Sheffield, Silvia Medrano) will add scientific and technical expertise to individual laboratories within and outside the Center. The Center will be supported by an Administrative Core which will allocate and distribute resources to Center participants, implement the Opportunity Pool Program with procedures for soliciting and selecting candidates for Pilot and Feasibility Awards, maintain a Center Website and an Enrichment / Educational program to provide resources for support of research students, the development of repository data, workshops, seminars, and symposia to enhance research in kidney development and disease. This Pediatric Center of Excellence in Nephrology has the necessary expertise, diverse manpower, focus, commitment, and institutional support to accomplish the proposed goals. It is anticipated that the Center of Excellence will lead to improved management of infants and children with renal diseases and hypertension.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $876,233 )
2024	2024	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	13	8/28/2024	NON-COMPETING CONTINUATION	$876,233
2024	2023	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	12	8/23/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $876,233

Issue Date FY: 2023 ( Subtotal = $876,233 )
2023	2023	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	12	8/30/2023	NON-COMPETING CONTINUATION	$876,233
2023	2022	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	11	6/28/2023	COMPETING CONTINUATION	$426,247
2023	2022	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	11	8/29/2023	COMPETING CONTINUATION	$0
2023	2021	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	6/28/2023	NON-COMPETING CONTINUATION	-$426,247
														Subtotal = $876,233

Issue Date FY: 2022 ( Subtotal = $878,693 )
2022	2022	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	11	9/1/2022	COMPETING CONTINUATION	$878,693
														Subtotal = $878,693

Issue Date FY: 2021 ( Subtotal = $852,720 )
2021	2021	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	9/3/2021	NON-COMPETING CONTINUATION	$852,720
														Subtotal = $852,720

Issue Date FY: 2020 ( Subtotal = $852,720 )
2020	2020	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	9	8/18/2020	NON-COMPETING CONTINUATION	$852,720
2020	2019	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	8	5/26/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $852,720

Issue Date FY: 2019 ( Subtotal = $885,098 )
2019	2019	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	8	9/11/2019	SUPPLEMENT FOR EXPANSION	$32,378
2019	2019	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	8	8/27/2019	NON-COMPETING CONTINUATION	$852,720
														Subtotal = $885,098

Issue Date FY: 2018 ( Subtotal = $885,102 )
2018	2018	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	004	7	8/15/2018	SUPPLEMENT FOR EXPANSION	$32,382
2018	2018	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	7	8/14/2018	NON-COMPETING CONTINUATION	$852,720
2018	2017	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	6	1/17/2018	COMPETING CONTINUATION	$35,416
2018	2016	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	1/17/2018	EXTENSION WITH OR WITHOUT FUNDS	-$2,761
2018	2016	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	5	1/17/2018	SUPPLEMENT FOR EXPANSION	-$32,655
														Subtotal = $885,102

Issue Date FY: 2017 ( Subtotal = $850,080 )
2017	2017	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	6	9/8/2017	COMPETING CONTINUATION	$850,080
2017	2016	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	5	2/17/2017	EXTENSION WITH OR WITHOUT FUNDS	$502,787
2017	2015	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	4	2/17/2017	SUPPLEMENT FOR EXPANSION	-$38,765
2017	2015	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	2/17/2017	NON-COMPETING CONTINUATION	-$464,022
														Subtotal = $850,080

Issue Date FY: 2016 ( Subtotal = $824,405 )
2016	2016	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	5	9/8/2016	SUPPLEMENT FOR EXPANSION	$32,655
2016	2016	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	9/7/2016	EXTENSION WITH OR WITHOUT FUNDS	$791,750
														Subtotal = $824,405

Issue Date FY: 2015 ( Subtotal = $830,515 )
2015	2015	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	4	9/7/2015	SUPPLEMENT FOR EXPANSION	$38,765
2015	2015	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	9/2/2015	NON-COMPETING CONTINUATION	$791,750
														Subtotal = $830,515

Issue Date FY: 2014 ( Subtotal = $824,405 )
2014	2014	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	3	9/16/2014	SUPPLEMENT FOR EXPANSION	$32,655
2014	2014	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	8/25/2014	NON-COMPETING CONTINUATION	$791,750
														Subtotal = $824,405

Issue Date FY: 2013 ( Subtotal = $779,276 )
2013	2013	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	9/5/2013	NON-COMPETING CONTINUATION	$746,621
2013	2013	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	2	9/9/2013	SUPPLEMENT FOR EXPANSION	$32,655
														Subtotal = $779,276

Issue Date FY: 2012 ( Subtotal = $909,599 )
2012	2012	UNIVERSITY OF VIRGINIA	P.O. BOX 400195	CHARLOTTESVILLE	VA	22904	CHARLOTTESVILLE CITY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	9/20/2012	NEW	$909,599
														Subtotal = $909,599

Grand Total All Awards = $11,125,079

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Regulation of Cell Fate during Kidney Development and Disease

Award Number: P50DK096373

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/21/2012

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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