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Iowa Cochlear Implant Clinical Research Center VII

Award Number: P50DC000242
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Program Director/Principal Investigator (Last, First, Middle): Gantz, Bruce J. PROJECT SUMMARY - OVERVIEW Hearing loss is a pervasive problem and, according to statistics from the NIDCD/NIH website, it is estimated that it affects nearly 37.5 million Americans aged 18 years and older. While remediation with hearing aids and cochlear implants has assisted those with moderate to profound loss, noise interferes with the ability to understand speech. Our research has identified the important advantage of combining acoustic+electric speech processing (A+E) to facilitate improved hearing in noise. Application of A+E processing has improved outcomes of cochlear implants in quiet and noise, but there is significant individual variability in outcome measures among subjects. To address these issues, this application requests continuation of the Iowa Cochlear Implant Clinical Research Center. In this proposal we will investigate hearing and auditory perception using studies that explore the mechanisms of electrical, acoustic, and A+E hearing from the auditory periphery to the cortex, including measures of cortical (re)organization and higher order language processing. Equally important, we also explore human ecology—factors in the person and in the environment that can mediate or impede successful communication and can be modified by A+E speech processing. Our overarching goal of this competitive renewal is to apply basic and cognitive neuroscience methodologies to assist us in addressing these fundamental questions about how individuals use both acoustic and electric auditory information. Four research projects, Human Ecology, Peripheral Electrophysiology, Central Auditory Integration and Cognitive Dynamics of Language Processing, an administrative and patient care/technical support cores are proposed. The overall objectives are to examine the impact that A+E processing function has on real-life socialization, cognition and quality of life issues, and to evaluate auditory processing from the periphery to cortical and higher level processing. We plan to study 200 newly implanted adult subjects with A+E hearing preservation implants, 50 subjects that use a hearing aid, 50 normal hearing subjects, and a combination of 300 previously implanted subjects with A+E, bimodal or single CIs that participate in our research registry. The four research projects are highly integrated and depend on data from each other to answer the experimental questions proposed.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $2,782,052 )
2023	2023	THE UNIVERSITY OF IOWA	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	002	36	6/9/2023	COMPETING CONTINUATION	$0
2023	2023	THE UNIVERSITY OF IOWA	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	001	36	5/13/2023	COMPETING CONTINUATION	$2,782,052
2023	2022	THE UNIVERSITY OF IOWA	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	35	5/10/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,782,052

Issue Date FY: 2022 ( Subtotal = $2,472,597 )
2022	2022	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	001	35	11/18/2021	NON-COMPETING CONTINUATION	$2,225,337
2022	2022	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	002	35	4/22/2022	NON-COMPETING CONTINUATION	$247,260
2022	2021	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	34	10/18/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,472,597

Issue Date FY: 2021 ( Subtotal = $2,472,597 )
2021	2021	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	001	34	1/7/2021	NON-COMPETING CONTINUATION	$247,260
2021	2021	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	34	11/25/2020	NON-COMPETING CONTINUATION	$2,225,337
														Subtotal = $2,472,597

Issue Date FY: 2020 ( Subtotal = $2,472,597 )
2020	2020	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	001	33	1/17/2020	NON-COMPETING CONTINUATION	$247,260
2020	2020	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	33	11/26/2019	NON-COMPETING CONTINUATION	$2,225,337
														Subtotal = $2,472,597

Issue Date FY: 2019 ( Subtotal = $2,472,597 )
2019	2019	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	32	1/3/2019	NON-COMPETING CONTINUATION	$2,472,597
														Subtotal = $2,472,597

Issue Date FY: 2018 ( Subtotal = $2,474,742 )
2018	2018	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	001	31	12/1/2017	COMPETING CONTINUATION	$2,474,742
2018	2018	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	003	31	3/1/2018	COMPETING CONTINUATION	$1,950
2018	2016	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	002	30	3/1/2018	EXTENSION WITH OR WITHOUT FUNDS	-$1,950
2018	2016	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	30	11/29/2017	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $2,474,742

Issue Date FY: 2016 ( Subtotal = $2,238,092 )
2016	2016	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	30	1/22/2016	EXTENSION WITH OR WITHOUT FUNDS	$2,238,092
														Subtotal = $2,238,092

Issue Date FY: 2015 ( Subtotal = $2,229,539 )
2015	2015	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	29	2/11/2015	NON-COMPETING CONTINUATION	$2,229,539
														Subtotal = $2,229,539

Issue Date FY: 2014 ( Subtotal = $2,238,092 )
2014	2014	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	001	28	2/10/2014	NON-COMPETING CONTINUATION	$223,809
2014	2014	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	28	1/29/2014	NON-COMPETING CONTINUATION	$2,014,283
														Subtotal = $2,238,092

Issue Date FY: 2013 ( Subtotal = $2,190,267 )
2013	2013	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	27	1/22/2013	NON-COMPETING CONTINUATION	$2,074,991
2013	2013	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	001	27	5/14/2013	NON-COMPETING CONTINUATION	$115,276
														Subtotal = $2,190,267

Issue Date FY: 2012 ( Subtotal = $2,253,192 )
2012	2012	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	26	2/10/2012	COMPETING CONTINUATION	$2,253,192
2012	2010	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	001	25	2/10/2012	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,253,192

Issue Date FY: 2011 ( Subtotal = $113,250 )
2011	2011	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	25	6/17/2011	SUPPLEMENT FOR EXPANSION	$113,250
														Subtotal = $113,250

Issue Date FY: 2010 ( Subtotal = $2,462,578 )
2010	2010	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	25	5/12/2010	NON-COMPETING CONTINUATION	$2,462,578
														Subtotal = $2,462,578

Issue Date FY: 2009 ( Subtotal = $2,413,500 )
2009	2009	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	24	6/3/2009	NON-COMPETING CONTINUATION	$2,413,500
														Subtotal = $2,413,500

Issue Date FY: 2008 ( Subtotal = $2,362,986 )
2008	2008	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	23	5/2/2008	NON-COMPETING CONTINUATION	$2,362,986
														Subtotal = $2,362,986

Issue Date FY: 2007 ( Subtotal = $2,261,232 )
2007	2007	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	001	22	7/31/2007	SUPPLEMENT FOR EXPANSION	$321,815
2007	2007	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	22	5/10/2007	NON-COMPETING CONTINUATION	$1,939,417
														Subtotal = $2,261,232

Issue Date FY: 2006 ( Subtotal = $1,950,782 )
2006	2006	UNIVERSITY OF IOWA	ROOM B5K, JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	21	5/26/2006	COMPETING CONTINUATION	$1,950,782
														Subtotal = $1,950,782

Issue Date FY: 2005 ( Subtotal = $2,106,360 )
2005	2005	UNIVERSITY OF IOWA	ROOM B5K, JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	Research Related to Deafness and Communication Disorders	000	20	5/18/2005	NON-COMPETING CONTINUATION	$2,106,360
														Subtotal = $2,106,360

Issue Date FY: 2004 ( Subtotal = $2,045,497 ) (Continued on the next page)
Grand Total All Awards = $50,158,891

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Iowa Cochlear Implant Clinical Research Center VII

Award Number: P50DC000242

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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