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Neuroscience, Immunology, Social Adversity and the Roots of Addictive Behaviors: Toward a New Framework for Drug Use Etiology and Prevention

Award Number: P50DA051361
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY: Overall Center The Center for Translational and Prevention Science (CTAPS; P20 MH068666, P30 DA027827) has been funded continuously since 2003 to advance next-generation basic and preventive investigations of risk, resilience, and drug use among African American young people living in resource poor communities in the southeastern US. CTAPS has pioneered research demonstrating how exposures to economic and social adversity promote drug use through their effects on neurobiological and peripheral systems. Of particular importance, research sponsored by CTAPS also has demonstrated the promise of family-centered drug use prevention programming in shielding young people from these neurobiological risks. At present, transformative progress in the prevention of addictive behavior among populations exposed to chronic stress has been hampered significantly by the lack of (a) integrative theoretical frameworks that generate hypotheses regarding the risk and resilience mechanisms that connect social adversity to addictive behavior and cardiometabolic risk, (b) infrastructures that can collect model driven data on multiple neurocognitive, peripheral biological, and behavioral systems associated with chronic stress, and (c) transdisciplinary teams that can integrate these data into the design and evaluation of prevention programs. The theoretical framework of the proposed P50 Research Center of Excellence is a next generation, neuroimmune network (NIN) model that CTAPS scientists developed to better describe the ways in which exposure to social adversity predispose young people to the onset and escalation of diverse forms of addictive behaviors. The NIN model specifies stress-induced alterations in the transactions between peripheral inflammation and neurocognitive systems that subserve emotion regulation in the development of addictive behavior vulnerability. As a P50 Center, we propose to build on and expand CTAPS’ pioneering work on (a) the biological and neurocognitive contributors to addictive behaviors that drive many drug use and health disparities African Americans’ experience and (b) the potential of family-centered prevention programming to ameliorate the influence of growing up in chronically stressful contexts. We will leverage an established team of investigators from diverse disciplines and an established infrastructure for testing transdisciplinary hypotheses. This infrastructure includes efficient, established pipelines connecting P50 research project (RP) and pilot study investigators to intellectual resources, wet labs, a state-of-the-science imaging facility, and a world class platform for processing imaging data. We will implement three innovative, thematically integrated RPs. RPs, innovative pilot projects, an expanded national resource system, and investigator development activities will be supported through our infrastructure system composed of a Research Support Core, an Administrative Core, and a Pilot Core. CTAPS activities will have wide-reaching implications for research, practice, and prevention concerning drug use and cardiometabolic risk in low-income and ethnic minority communities. 1


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 E CAMPUS RD RM 409	ATHENS	GA	30602	CLARKE	USA	Drug Abuse and Addiction Research Programs	000	4	1/9/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $1,983,814 )
2023	2023	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Drug Abuse and Addiction Research Programs	002	4	7/11/2023	NON-COMPETING CONTINUATION	$1,983,814
2023	2022	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Drug Abuse and Addiction Research Programs	001	3	4/18/2023	NON-COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Drug Abuse and Addiction Research Programs	000	3	1/4/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,983,814

Issue Date FY: 2022 ( Subtotal = $2,077,136 )
2022	2022	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Drug Abuse and Addiction Research Programs	002	3	7/25/2022	NON-COMPETING CONTINUATION	$2,077,136
2022	2021	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Drug Abuse and Addiction Research Programs	000	2	2/8/2022	NON-COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Drug Abuse and Addiction Research Programs	001	2	2/25/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,077,136

Issue Date FY: 2021 ( Subtotal = $2,064,702 )
2021	2021	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Drug Abuse and Addiction Research Programs	000	2	7/21/2021	NON-COMPETING CONTINUATION	$2,064,702
														Subtotal = $2,064,702

Issue Date FY: 2020 ( Subtotal = $1,781,382 )
2020	2020	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Drug Abuse and Addiction Research Programs	000	1	8/17/2020	NEW	$1,781,382
														Subtotal = $1,781,382

Grand Total All Awards = $7,907,034

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Neuroscience, Immunology, Social Adversity and the Roots of Addictive Behaviors: Toward a New Framework for Drug Use Etiology and Prevention

Award Number: P50DA051361

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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