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Center for Adolescent Reward, Rhythms and Sleep (CARRS)

Award Number: P50DA046346
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/15/2020
PERIOD OF PERFORMANCE END DATE: 08/31/2025

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Center for Adolescent Reward, Rhythms and Sleep (CARRS) - PROJECT SUMMARY We are proposing a NIDA Research Center of Excellence (P50) entitled, Center for Adolescent Reward, Rhythms and Sleep (CARRS). Adolescence is a vulnerable time for substance abuse. This risk reflects the heightened reward system of adolescence, which is found regardless of cultural upbringing or home environment, relative to both adults and children. In addition, genetic, social and environmental factors influence the amount of sleep and circadian rhythm misalignment experienced by the adolescent brain. The goal of CARRS is to integrate human and rodent studies to understand the impact of adolescent sleep and circadian rhythm changes (both biologically and environmentally induced) on reward circuitry and substance use (SU)- relevant outcomes. We will use experimental manipulations to further examine how sleep and circadian rhythms affect reward function and SU-related outcomes, with the ultimate goal of developing novel prevention or intervention strategies. Late sleep timing, short sleep duration and circadian misalignment are associated with increased substance use in teenagers and young adults. The central hypothesis of the Center is that adolescent development acts on underlying sleep and circadian traits to modify homeostatic sleep drive, circadian phase, and circadian alignment, which in turn impact cortico-limbic functions critical to substance use risk (e.g., reward and cognitive control). We further hypothesize that specific manipulations of sleep and circadian rhythms during adolescence will affect reward responsivity and cognitive control in either positive or negative directions. These manipulations will provide experimental support for our model, and proof of concept for novel clinical interventions to reduce the risk of substance use disorders. In turn, abuse of drugs will also impact the circadian, reward and sleep systems, creating a vicious cycle. Interventions that help stabilize the circadian and sleep systems, or reduce the damage done by these disruptions, may be protective against substance abuse in vulnerable individuals. The goals of the center are to 1) Determine the role of sleep and circadian rhythms in reward sensitivity and substance use (SU) in adolescence. 2) Conduct translational research aimed at the development of interventions to reduce risk in at-risk individuals. 3) Partner with other Centers and the addiction research community to inform and complement ongoing research. 4) Provide training and education on sleep, circadian rhythms, and substance use.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2027 ( Subtotal = -$58 )
2027	2024	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Drug Use and Addiction Research Programs	000	5	10/14/2026	NON-COMPETING CONTINUATION	-$58
														Subtotal = -$58

Issue Date FY: 2026 ( Subtotal = $2,856,220 )
2026	2026	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Drug Use and Addiction Research Programs	003	7	6/9/2026	NON-COMPETING CONTINUATION	$2,856,220
2026	2025	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Drug Use and Addiction Research Programs	002	6	5/14/2026	COMPETING CONTINUATION	$0
2026	2024	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Drug Use and Addiction Research Programs	001	5	5/6/2026	NON-COMPETING CONTINUATION	$0
2026	2024	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Drug Use and Addiction Research Programs	000	5	11/19/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,856,220

Issue Date FY: 2025 ( Subtotal = $2,860,596 )
2025	2025	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Drug Use and Addiction Research Programs	000	6	8/22/2025	COMPETING CONTINUATION	$2,860,596
														Subtotal = $2,860,596

Issue Date FY: 2024 ( Subtotal = $2,983,571 )
2024	2024	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Drug Use and Addiction Research Programs	000	5	7/2/2024	NON-COMPETING CONTINUATION	$2,983,571
														Subtotal = $2,983,571

Issue Date FY: 2023 ( Subtotal = $2,982,653 )
2023	2023	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Drug Use and Addiction Research Programs	000	4	7/21/2023	NON-COMPETING CONTINUATION	$2,982,653
														Subtotal = $2,982,653

Issue Date FY: 2022 ( Subtotal = $2,982,281 )
2022	2022	UNIVERSITY OF PITTSBURGH, THE	4200 5TH AVE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Drug Use and Addiction Research Programs	000	3	6/29/2022	NON-COMPETING CONTINUATION	$2,982,281
														Subtotal = $2,982,281

Issue Date FY: 2021 ( Subtotal = $2,937,638 )
2021	2021	UNIVERSITY OF PITTSBURGH, THE	4200 5TH AVE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Drug Use and Addiction Research Programs	001	2	7/1/2021	NON-COMPETING CONTINUATION	$2,937,638
2021	2020	UNIVERSITY OF PITTSBURGH THE	3520 FIFTH AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Drug Use and Addiction Research Programs	000	1	2/17/2021	NEW	$0
														Subtotal = $2,937,638

Issue Date FY: 2020 ( Subtotal = $2,936,360 )
2020	2020	UNIVERSITY OF PITTSBURGH THE	3520 FIFTH AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Drug Use and Addiction Research Programs	000	1	7/15/2020	NEW	$2,936,360
														Subtotal = $2,936,360

Grand Total All Awards = $20,539,261

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Center for Adolescent Reward, Rhythms and Sleep (CARRS)

Award Number: P50DA046346

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/15/2020

PERIOD OF PERFORMANCE END DATE: 08/31/2025

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