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Center for the Neurobiology of Addiction Treatment

Award Number: P50DA006634
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/1991
PERIOD OF PERFORMANCE END DATE: 11/30/2020

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Center for the Neurobiology of Addiction Treatment - DESCRIPTION (provided by applicant): The Center for the Neurobiology of Addiction Treatment (CNAT) is a renewal of a P50 Center at Wake Forest University Health Sciences that has been continuously funded by NIDA since 1991 and extensively re- designed at its last funding in 2009. The Specific Aims are: 1. to provide a novel mechanism of interaction among NIDA investigators at Wake Forest University to examine neurobiological mechanisms of cocaine pharmacotherapies, using tightly interacting projects to ensure an effective collaborative structure; 2. to provide a formal structure of collaborative interactions between our Center and our clinical partners at NIDA-funded clinical centers, thus providing a novel translational component to our research; 3. to provide a focus for the training of students and postdoctoral fellows in contemporary methods for investigating the neurobiological basis of drug abuse; 4. to serve as an information source to both the lay and scientific community on issues related to the neurobiological aspects of drug abuse. The scientific theme of the Center is focused on examining the neurobiological mechanisms of action of potential cocaine pharmacotherapeutic agents, with a focus on the use of drug combinations, using two treatment drugs that act through different pharmacological mechanisms to provide synergistic effects. The Center's novel strategy to identify potential drug combination pharmacotherapies is to utilize one drug that decreases cocaine reinforcement through the nucleus acumens dopaminergic pathway, with the other drug acting to reverse cocaine-induced deficits in cognition, i.e., cognitive remediators. The Center contains three cores and three major projects. The projects are highly interactive, with each project's activities dependent on results obtained from the other two projects. Project 1 will examine effects of combination drug treatment on various behavioral models in both rats and monkeys; Project 2 will explore how these combination drug treatment paradigms affect functional consequences in brain through neuro-imaging and voltammetry; and Project 3 will explore how these drug treatments affect gene expression, receptor function and signal transduction systems. The Center contains an Administrative Core and a Pilot Studies Core, while the Animal/Tissue Core will provide uniform sets of brain tissue samples from different rat models to the projects. These projects utilize several animal behavioral models and technologies uniquely developed by the Center investigators over the previous years of its funding history.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$3,947 )
2023	2019	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	000	27	2/2/2023	NON-COMPETING CONTINUATION	-$3,947
														Subtotal = -$3,947

Issue Date FY: 2021 ( Subtotal = -$201,540 )
2021	2019	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	000	27	5/22/2021	NON-COMPETING CONTINUATION	-$201,540
														Subtotal = -$201,540

Issue Date FY: 2019 ( Subtotal = $1,589,690 )
2019	2019	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	000	27	3/1/2019	NON-COMPETING CONTINUATION	$1,589,690
														Subtotal = $1,589,690

Issue Date FY: 2018 ( Subtotal = $1,588,199 )
2018	2018	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	000	26	2/20/2018	NON-COMPETING CONTINUATION	$1,429,379
2018	2018	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	001	26	4/26/2018	NON-COMPETING CONTINUATION	$158,820
														Subtotal = $1,588,199

Issue Date FY: 2017 ( Subtotal = $1,586,793 )
2017	2017	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	001	25	5/22/2017	NON-COMPETING CONTINUATION	$158,679
2017	2017	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	000	25	2/17/2017	NON-COMPETING CONTINUATION	$1,428,114
														Subtotal = $1,586,793

Issue Date FY: 2016 ( Subtotal = $1,569,610 )
2016	2016	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	000	24	2/25/2016	NON-COMPETING CONTINUATION	$1,569,610
														Subtotal = $1,569,610

Issue Date FY: 2015 ( Subtotal = $1,617,079 )
2015	2015	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	000	23	5/15/2015	COMPETING CONTINUATION	$1,617,079
														Subtotal = $1,617,079

Issue Date FY: 2014 ( Subtotal = $153,318 )
2014	2014	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	000	22	5/29/2014	SUPPLEMENT FOR EXPANSION	$153,318
														Subtotal = $153,318

Issue Date FY: 2013 ( Subtotal = $1,461,781 )
2013	2013	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	000	22	5/30/2013	NON-COMPETING CONTINUATION	$1,461,781
														Subtotal = $1,461,781

Issue Date FY: 2012 ( Subtotal = $1,802,001 )
2012	2012	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	000	21	5/18/2012	NON-COMPETING CONTINUATION	$1,802,001
														Subtotal = $1,802,001

Issue Date FY: 2011 ( Subtotal = $1,804,431 )
2011	2011	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	000	20	5/26/2011	NON-COMPETING CONTINUATION	$1,804,431
														Subtotal = $1,804,431

Issue Date FY: 2010 ( Subtotal = $1,807,449 )
2010	2010	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	000	19	5/24/2010	NON-COMPETING CONTINUATION	$1,807,449
														Subtotal = $1,807,449

Issue Date FY: 2009 ( Subtotal = $1,516,519 )
2009	2009	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	001	18	9/17/2009	COMPETING CONTINUATION	$1,516,519
2009	2008	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	000	17	9/17/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,516,519

Issue Date FY: 2008 ( Subtotal = $1,649,996 )
2008	2008	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	000	17	4/14/2008	NON-COMPETING CONTINUATION	$1,649,996
														Subtotal = $1,649,996

Issue Date FY: 2007 ( Subtotal = $1,636,057 )
2007	2007	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	000	16	3/26/2007	NON-COMPETING CONTINUATION	$1,636,057
														Subtotal = $1,636,057

Issue Date FY: 2006 ( Subtotal = $1,636,205 )
2006	2006	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	000	15	5/4/2006	NON-COMPETING CONTINUATION	$1,636,205
														Subtotal = $1,636,205

Issue Date FY: 2005 ( Subtotal = $1,627,153 )
2005	2005	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	000	14	4/1/2005	NON-COMPETING CONTINUATION	$1,627,153
														Subtotal = $1,627,153

Issue Date FY: 2004 ( Subtotal = $1,597,319 )
2004	2004	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	000	13	6/15/2004	COMPETING CONTINUATION	$1,597,319
														Subtotal = $1,597,319

Issue Date FY: 2003 ( Subtotal = $1,514,226 )
2003	2003	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Drug Use and Addiction Research Programs	000	12		NON-COMPETING CONTINUATION	$1,514,226
														Subtotal = $1,514,226

Issue Date FY: 2002 ( Subtotal = $1,531,072 )
2002	2002	WAKE FOREST UNIVERSITY SCHOOL OF MEDICINE	MEDICAL CENTER BOULEVARD	WINSTON-SALEM	NC	27157		USA	Drug Use and Addiction Research Programs	000	11	12/7/2001	NON-COMPETING CONTINUATION	$1,531,072
														Subtotal = $1,531,072

Issue Date FY: 2001 ( Subtotal = $1,486,483 )
2001	2001	WAKE FOREST UNIVERSITY SCHOOL OF MEDICINE	MEDICAL CENTER BOULEVARD	WINSTON-SALEM	NC	27157		USA	Drug Use and Addiction Research Programs	000	10	12/6/2000	NON-COMPETING CONTINUATION	$1,486,483
														Subtotal = $1,486,483

Issue Date FY: 2000 ( Subtotal = $1,586,483 )
2000	2000	WAKE FOREST UNIVERSITY SCHOOL OF MEDICINE	MEDICAL CENTER BOULEVARD	WINSTON-SALEM	NC	27157		USA	Drug Use and Addiction Research Programs	000	9	9/25/2000	NON-COMPETING CONTINUATION	$1,545,013
2000	2000	WAKE FOREST UNIVERSITY SCHOOL OF MEDICINE	MEDICAL CENTER BOULEVARD	WINSTON-SALEM	NC	27157		USA	Drug Use and Addiction Research Programs	001	9	7/13/2000	SUPPLEMENT FOR EXPANSION	$41,470
														Subtotal = $1,586,483

Issue Date FY: 1999 ( Subtotal = $1,367,896 ) (Continued on the next page)
1999	1999	WAKE FOREST UNIVERSITY SCHOOL OF MEDICINE	MEDICAL CENTER BOULEVARD	WINSTON-SALEM	NC	27157		USA	Drug Use and Addiction Research Programs	002	8	9/21/1999	SUPPLEMENT FOR EXPANSION	$89,900
Grand Total All Awards = $32,124,273

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Center for the Neurobiology of Addiction Treatment

Award Number: P50DA006634

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/1991

PERIOD OF PERFORMANCE END DATE: 11/30/2020

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