Tuesday, January 27, 2026 1/27/2026

Head and Neck Cancer SPORE at the University of Wisconsin

Award Number: P50CA278595
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/02/2016
PERIOD OF PERFORMANCE END DATE: 07/31/2027

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Head and Neck Cancer SPORE at the University of Wisconsin - PROJECT SUMMARY The Wisconsin Head and Neck SPORE is designed to promote translational laboratory and clinical research to improve overall outcome for patients with Head and Neck Cancer (HNC). This highly collaborative research links basic scientists with HNC clinicians to advance novel treatment strategies for this complex cancer population. These patients bear a disproportionate burden from their cancers based on the critical anatomic location of the disease for which treatment can compromise speech, swallow, and breathing function, in addition to creating significant alterations in physical appearance and capacity for social interaction. Efforts to improve cure rates must be carefully balanced with efforts to reduce treatment toxicity to enable enhanced overall quality of life for patients. The broad objectives of this SPORE are to: 1) Promote multidisciplinary translational research in HNC, 2) Improve overall survival and quality of life for patients with HNC, 3) Incorporate new predictive models to test novel HNC treatment strategies, 4) Improve understanding of how immune modulation can augment conventional and experimental treatment responses in HNC, 5) Translate promising new molecules developed at the University of Wisconsin and from Industry through preclinical testing and into HNC clinical trials. The Wisconsin HN SPORE has designed three primary research projects. Project 1 will combine targeted radionuclide therapies (TRT) with immune checkpoint inhibition (ICI) to stimulate enhanced HNC response profiles culminating in a Phase I clinical trial. Project 2 builds a powerful patient-specific bioengineered HNC model system from patient cells that incorporates components of the tumor microenvironment to more accurately predict HNC patient treatment response. The feasibility of using treatment response data from the model to inform postoperative radiation therapy will be tested in a clinical pilot study. Project 3 examines dual targeting of critical receptor tyrosine kinases Axl and MerTK to mediate changes in the immune microenvironment and thereby augment tumor response in HNC patients. The Wisconsin SPORE will support this research with three Cores (Administrative, Pathology and Biostatistics), a Career Enhancement Program and a Developmental Research Program.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Centers Support Grants	000	9	12/22/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $2,133,489 )
2025	2025	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Centers Support Grants	000	9	8/12/2025	NON-COMPETING CONTINUATION	$2,133,489
														Subtotal = $2,133,489

Issue Date FY: 2024 ( Subtotal = $2,049,112 )
2024	2024	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Centers Support Grants	002	8	8/19/2024	NON-COMPETING CONTINUATION	$2,049,112
2024	2023	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Centers Support Grants	001	7	6/7/2024	NON-COMPETING CONTINUATION	$0
2024	2023	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Centers Support Grants	000	7	3/14/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,049,112

Issue Date FY: 2023 ( Subtotal = $2,021,232 )
2023	2023	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Centers Support Grants	001	7	8/9/2023	NON-COMPETING CONTINUATION	$2,021,133
2023	2022	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Centers Support Grants	000	6	5/18/2023	COMPETING CONTINUATION	$99
														Subtotal = $2,021,232

Issue Date FY: 2022 ( Subtotal = $2,028,647 )
2022	2022	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Centers Support Grants	002	6	9/21/2022	COMPETING CONTINUATION	$43,627
2022	2022	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Centers Support Grants	001	6	8/4/2022	COMPETING CONTINUATION	$0
2022	2022	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Centers Support Grants	000	6	7/29/2022	COMPETING CONTINUATION	$1,985,020
														Subtotal = $2,028,647

Grand Total All Awards = $8,232,480

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Head and Neck Cancer SPORE at the University of Wisconsin

Award Number: P50CA278595

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/02/2016

PERIOD OF PERFORMANCE END DATE: 07/31/2027

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