Monday, June 30, 2025 6/30/2025

Yale SPORE in Lung Cancer (YSILC): The Biology and Personalized Treatment of Lung Cancer

Award Number: P50CA196530
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/26/2015
PERIOD OF PERFORMANCE END DATE: 07/31/2025

Group Awards By:

View Award Description

Yale SPORE in Lung Cancer (YSILC): The Biology and Personalized Treatment of Lung Cancer - YALE SPORE IN LUNG CANCER (YSILC) OVERALL SUMMARY The Biology and Personalized Treatment of Primary and Metastatic Lung Cancer: The YSILC unites translational scientists spanning diverse areas of cancer research to converge on addressing the challenge of lung cancer. The goal of the YSILC is to reduce mortality from lung cancer through development of novel therapeutics and treatment approaches that are based on an understanding of targetable biochemical and immunological pathways involved in progression of lung cancer, acquisition of resistance, and development of metastasis The YSILC translational research team will accomplish this objective through three projects: Project 1: Test the hypotheses that Siglec-15 (S15) is a major immune suppressor in PD-L1/B7-H1-negative lung cancer and that blockade of S15 can be efficacious for a subset of lung cancer patients; Project 2: Evaluate mechanism-based approaches to counter tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer; Project 3: Targeting lung cancer metastasis and drug resistance in the central nervous system. There are three Cores (Administrative; Biostatistics and Bioinformatics; and Biospecimen, Pathology, and Genomics) to support the projects and their clinical aims, mechanistic studies, and evaluation of biomarkers for clinical application. Strong Developmental Research and Career Enhancement Programs (DRP, CEP) with a history of choosing diverse and productive projects with good outcomes are also proposed. The highly coordinated YSILC projects, cores, and programs are focused on developing novel lung cancer therapies, with analysis of patient samples, cell-based assays, production of human cell lines and animal models of disease as a guide to design prospective trials that translate these innovative targeted approaches to clinical therapies. Each of these projects has a clinical trial (either investigator-initiated or NCI-based) designed to test the sensitivity and resistance of the new therapy with molecular correlates. The expected translational outcomes of the program include: (1) a highly coordinated and focused development of a novel immune agent discovered during our current SPORE research; (2) an improved understanding of genetic and epigenetic mechanisms of resistance to EGFR therapies and how to combat it; (3) an understanding of the mechanism underlying brain metastasis; (4) expanding the breadth of lung cancer research by developing the next generation of investigators and encouraging established investigators in other fields to pursue studies on lung cancer through our CEP and DRP programs.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Centers Support Grants	000	10	3/18/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $2,356,373 )
2024	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Centers Support Grants	003	10	8/15/2024	NON-COMPETING CONTINUATION	$2,137,785
2024	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Centers Support Grants	004	10	8/20/2024	SUPPLEMENT FOR EXPANSION	$218,588
2024	2023	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Centers Support Grants	002	9	7/12/2024	NON-COMPETING CONTINUATION	$0
2024	2023	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Centers Support Grants	001	9	5/9/2024	NON-COMPETING CONTINUATION	$0
2024	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Centers Support Grants	000	9	12/13/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,356,373

Issue Date FY: 2023 ( Subtotal = $2,069,846 )
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Centers Support Grants	001	9	8/7/2023	NON-COMPETING CONTINUATION	$2,069,846
2023	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Centers Support Grants	000	8	5/12/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,069,846

Issue Date FY: 2022 ( Subtotal = $2,046,999 )
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Centers Support Grants	001	8	8/23/2022	NON-COMPETING CONTINUATION	$2,002,480
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Centers Support Grants	002	8	9/21/2022	NON-COMPETING CONTINUATION	$44,519
2022	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Centers Support Grants	000	7	6/20/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,046,999

Issue Date FY: 2021 ( Subtotal = $2,003,668 )
2021	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Centers Support Grants	002	7	9/1/2021	NON-COMPETING CONTINUATION	$2,003,668
2021	2020	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Centers Support Grants	001	6	2/11/2021	COMPETING CONTINUATION	$66,596
2021	2019	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Centers Support Grants	000	5	2/11/2021	NON-COMPETING CONTINUATION	-$66,596
														Subtotal = $2,003,668

Issue Date FY: 2020 ( Subtotal = $2,207,890 )
2020	2020	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Centers Support Grants	000	6	6/26/2020	COMPETING CONTINUATION	$2,207,890
														Subtotal = $2,207,890

Issue Date FY: 2019 ( Subtotal = $2,134,771 )
2019	2019	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Centers Support Grants	001	5	8/21/2019	NON-COMPETING CONTINUATION	$2,134,771
2019	2018	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Centers Support Grants	000	4	4/11/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,134,771

Issue Date FY: 2018 ( Subtotal = $2,507,598 )
2018	2018	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Centers Support Grants	001	4	8/20/2018	NON-COMPETING CONTINUATION	$2,507,598
2018	2016	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Centers Support Grants	000	2	3/13/2018	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $2,507,598

Issue Date FY: 2017 ( Subtotal = $2,507,600 )
2017	2017	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Centers Support Grants	003	3	9/21/2017	NON-COMPETING CONTINUATION	$115,000
2017	2017	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Centers Support Grants	000	3	7/17/2017	NON-COMPETING CONTINUATION	$2,185,000
2017	2017	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Centers Support Grants	002	3	9/20/2017	SUPPLEMENT FOR EXPANSION	$207,600
2017	2016	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Centers Support Grants	001	2	7/19/2017	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $2,507,600

Issue Date FY: 2016 ( Subtotal = $2,877,087 )
2016	2016	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Cancer Centers Support Grants	000	2	8/2/2016	NON-COMPETING CONTINUATION	$2,161,996
2016	2016	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Cancer Centers Support Grants	001	2	9/1/2016	SUPPLEMENT FOR EXPANSION	$715,091
														Subtotal = $2,877,087

Issue Date FY: 2015 ( Subtotal = $2,185,000 )
2015	2015	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Cancer Centers Support Grants	000	1	8/27/2015	NEW	$2,185,000
														Subtotal = $2,185,000

Grand Total All Awards = $22,896,832

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Yale SPORE in Lung Cancer (YSILC): The Biology and Personalized Treatment of Lung Cancer

Award Number: P50CA196530

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/26/2015

PERIOD OF PERFORMANCE END DATE: 07/31/2025

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer