Monday, December 15, 2025 12/15/2025

Translational Research in Breast Cancer

Award Number: P50CA186784
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/19/2014
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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Translational Research in Breast Cancer - Abstract Lack of progress in curing metastatic breast cancer is due to a number of fundamental treatment barriers. These include insufficient knowledge of therapeutic vulnerabilities, lack of reliable predictive biomarkers, inability to target common tumor suppressor gene loss, inability to target oncogenes that are not protein kinases or ligand- dependent transcription factors, resistance due to clonal evolution and tumor heterogeneity, and failure to mount an immune response against the tumor. This SPORE renewal focuses on these obstacles by articulating cross- cutting objectives and aligned approaches that increase the efficiency of core utilization and promote inter-project collaboration. The three full Projects include studies on how to target the derepressed kinases consequent upon loss of the PTPN12 or the NF1 tumor suppressors in breast cancer, and the development of a promising new therapeutic approach for MYC-positive breast cancer. During the execution of these Projects we will: a) deploy proteogenomic approaches for monitoring kinase targets and resistance pathways; b) establish high-quality biomarkers for clinical trial eligibility and stratification; c) investigate disease-monitoring approaches with circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA); d) incorporate immunological approaches into treatment regimens by increasing the quality and quantity of tumor infiltrating lymphocytes; e) embed our SPORE biomarker program into early phase clinical trials to inform the design of Phase 3 trials; and f) promote collaborative research between Academia, NCI-Supported Cooperative Groups, Industry, and Advocacy Groups. These objectives are served by three reformatted Cores, with the addition of a dedicated and highly-qualified molecular research pathologist for the Pathology and Biobanking Core, the addition of deeper bioinformatics expertise to the Informatics and Biostatistics Core, and a new SPORE director plus additional advocates and advisory board members for the Administration Core. The Career Enhancement and Developmental Research Programs will be guided by highly experienced leadership and, as before, will cement the future of our SPORE. With this powerful enhanced program we will advocate nationally for progress in the treatment of advanced breast cancer, with the conviction that a cure is a near-term possibility.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Cancer Centers Support Grants	000	10	11/26/2025	SUPPLEMENT FOR EXPANSION	$0
2026	2024	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Cancer Centers Support Grants	001	10	12/5/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $1,230,080 )
2025	2025	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Cancer Centers Support Grants	001	10	9/19/2025	SUPPLEMENT FOR EXPANSION	$1,230,080
2025	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Cancer Centers Support Grants	000	9	9/15/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,230,080

Issue Date FY: 2024 ( Subtotal = $1,709,045 )
2024	2024	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Cancer Centers Support Grants	002	10	9/12/2024	NON-COMPETING CONTINUATION	$1,709,045
2024	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Cancer Centers Support Grants	001	9	5/31/2024	NON-COMPETING CONTINUATION	$0
2024	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Cancer Centers Support Grants	000	9	11/3/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,709,045

Issue Date FY: 2023 ( Subtotal = $1,974,356 )
2023	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Cancer Centers Support Grants	003	9	9/11/2023	NON-COMPETING CONTINUATION	$1,974,356
2023	2022	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Cancer Centers Support Grants	000	8	11/2/2022	NON-COMPETING CONTINUATION	$0
2023	2020	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Cancer Centers Support Grants	002	6	2/27/2023	COMPETING CONTINUATION	$31,210
2023	2018	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Cancer Centers Support Grants	001	5	2/27/2023	NON-COMPETING CONTINUATION	-$31,210
														Subtotal = $1,974,356

Issue Date FY: 2022 ( Subtotal = $2,091,509 )
2022	2022	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Cancer Centers Support Grants	001	8	9/13/2022	NON-COMPETING CONTINUATION	$2,046,531
2022	2022	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Cancer Centers Support Grants	002	8	9/22/2022	NON-COMPETING CONTINUATION	$44,978
2022	2021	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Centers Support Grants	000	7	5/9/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,091,509

Issue Date FY: 2021 ( Subtotal = $2,092,818 )
2021	2021	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Centers Support Grants	003	7	7/30/2021	NON-COMPETING CONTINUATION	$2,092,818
2021	2020	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Centers Support Grants	002	6	5/5/2021	COMPETING CONTINUATION	$0
2021	2020	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Centers Support Grants	001	6	2/14/2021	COMPETING CONTINUATION	$31,840
2021	2018	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Centers Support Grants	000	5	2/14/2021	NON-COMPETING CONTINUATION	-$31,840
														Subtotal = $2,092,818

Issue Date FY: 2020 ( Subtotal = $2,137,830 )
2020	2020	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Centers Support Grants	002	6	8/17/2020	COMPETING CONTINUATION	$0
2020	2020	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Centers Support Grants	001	6	7/20/2020	COMPETING CONTINUATION	$2,137,830
2020	2020	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Centers Support Grants	003	6	9/14/2020	COMPETING CONTINUATION	$0
2020	2018	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Centers Support Grants	000	5	7/8/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,137,830

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2018	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Centers Support Grants	000	5	5/17/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $2,251,410 )
2018	2018	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Centers Support Grants	000	5	8/20/2018	NON-COMPETING CONTINUATION	$2,251,410
														Subtotal = $2,251,410

Issue Date FY: 2017 ( Subtotal = $2,300,000 )
2017	2017	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Centers Support Grants	000	4	8/29/2017	NON-COMPETING CONTINUATION	$2,105,749
2017	2017	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Centers Support Grants	001	4	9/21/2017	NON-COMPETING CONTINUATION	$194,251
														Subtotal = $2,300,000

Issue Date FY: 2016 ( Subtotal = $2,911,998 )
2016	2016	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Centers Support Grants	001	3	9/1/2016	SUPPLEMENT FOR EXPANSION	$750,000
2016	2016	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Centers Support Grants	000	3	8/12/2016	NON-COMPETING CONTINUATION	$2,161,998
														Subtotal = $2,911,998

Issue Date FY: 2015 ( Subtotal = $2,184,998 )
2015	2015	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Centers Support Grants	000	2	8/14/2015	NON-COMPETING CONTINUATION	$2,184,998
														Subtotal = $2,184,998

Issue Date FY: 2014 ( Subtotal = $2,162,000 )
2014	2014	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Cancer Centers Support Grants	000	1	9/19/2014	NEW	$2,162,000
														Subtotal = $2,162,000

Grand Total All Awards = $23,046,044

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Translational Research in Breast Cancer

Award Number: P50CA186784

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/19/2014

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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