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SPORE in Prostate Cancer

Award Number: P50CA180995
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/18/2015
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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SPORE in Prostate Cancer - OVERALL: ABSTRACT This application is a request for renewal funding of the SPORE in Prostate Cancer P50 CA180995 at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University in collaboration with the University of Chicago Comprehensive Cancer Center and NorthShore University HealthSystem, an affiliate of the University of Chicago. The SPORE first received support from the National Cancer Institute in 2001; a renewal application was funded in 2009. In 2015, we were the recipients of a new SPORE and we are now requesting continued funding for this program. Our SPORE unites basic scientists, clinicians, pathologists, biostatisticians, bioinformaticists and advocates from our academic institutions, all of whom are dedicated to advancing translational prostate cancer research. In this application we propose three highly translational and innovative research projects that have both basic science and clinical science co-leadership: Project 1: Targeting the MYC Pathway in Prostate Cancer (Abdulkadir, Hussain); Project 2: Re-directing the sensitivity of metastatic castration-resistant prostate cancer to immunotherapy (Wu, Sosman, Morgans); Project 3: STING Activation to Overcome Resistance to Immune Checkpoint Blockade in PTEN-deficient Prostate Cancer (Patnaik, Gajewski, Stadler). Three core facilities support the proposed research projects: Administrative, Leadership and Advocacy (Abdulkadir, Hussain, Stadler); Biostatistics/Bioinformatics (Kocherginsky, Zhao) and Biospecimen (Yang). Internal and External Advisory Boards provide a source of scientific input to members of the SPORE team on a biannual and yearly basis, respectively. Our Advocacy Group are well established in the SPORE arena and make a valued contribution to our success. The SPORE includes Developmental Research and Career Enhancement Programs, both of which provide a source of innovation and new discoveries. All together, we anticipate that the results obtained from our research endeavors will have a significant impact on the health of patients diagnosed with prostate cancer.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $1,805,886 )
2024	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	000	9	8/30/2024	NON-COMPETING CONTINUATION	$1,805,886
														Subtotal = $1,805,886

Issue Date FY: 2023 ( Subtotal = $1,758,412 )
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	001	8	7/28/2023	NON-COMPETING CONTINUATION	$1,758,412
2023	2022	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	000	7	5/5/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,758,412

Issue Date FY: 2022 ( Subtotal = $1,759,336 )
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	002	7	9/1/2022	NON-COMPETING CONTINUATION	$1,725,461
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	003	7	9/7/2022	NON-COMPETING CONTINUATION	-$4,048
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	004	7	9/22/2022	NON-COMPETING CONTINUATION	$37,923
2022	2021	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	001	6	3/24/2022	COMPETING CONTINUATION	$4,049
2022	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	000	5	3/24/2022	NON-COMPETING CONTINUATION	-$4,049
														Subtotal = $1,759,336

Issue Date FY: 2021 ( Subtotal = $1,656,783 )
2021	2021	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	000	6	9/1/2021	COMPETING CONTINUATION	$1,656,783
														Subtotal = $1,656,783

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	001	5	5/1/2020	NON-COMPETING CONTINUATION	$26,805
2020	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	000	5	3/19/2020	NON-COMPETING CONTINUATION	-$26,805
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $2,126,680 )
2019	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	000	5	8/13/2019	NON-COMPETING CONTINUATION	$2,126,680
														Subtotal = $2,126,680

Issue Date FY: 2018 ( Subtotal = $2,289,160 )
2018	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	000	4	7/27/2018	NON-COMPETING CONTINUATION	$2,289,160
														Subtotal = $2,289,160

Issue Date FY: 2017 ( Subtotal = $2,293,078 )
2017	2017	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	000	3	7/24/2017	NON-COMPETING CONTINUATION	$2,178,424
2017	2017	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	001	3	9/20/2017	NON-COMPETING CONTINUATION	$114,654
														Subtotal = $2,293,078

Issue Date FY: 2016 ( Subtotal = $2,158,540 )
2016	2016	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	000	2	8/1/2016	NON-COMPETING CONTINUATION	$2,158,540
														Subtotal = $2,158,540

Issue Date FY: 2015 ( Subtotal = $2,185,000 )
2015	2015	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Cancer Centers Support Grants	000	1	8/18/2015	NEW	$2,185,000
														Subtotal = $2,185,000

Grand Total All Awards = $18,032,875

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SPORE in Prostate Cancer

Award Number: P50CA180995

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/18/2015

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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