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Brain Tumor SPORE Grant

Award Number: P50CA097257
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/20/2002
PERIOD OF PERFORMANCE END DATE: 08/31/2028

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Brain Tumor SPORE Grant - Project Summary/Abstract This SPORE renewal application represents the efforts of interdisciplinary teams of investigators from the Neuro- Oncology Program of the UCSF Helen Diller Family Comprehensive Cancer Center (HDFCCC) to build on our accomplishments to continue to translate our findings to improve care for patients with brain cancer. We have three specific objectives: (1) to develop novel peripheral blood-based biomarkers for glioma patients, (2) to identify novel metabolic markers for noninvasive imaging to evaluate tumor burden and treatment response, and (3) to develop a novel immunotherapy strategy to overcome the current significant challenges. At the heart of the proposal are three translational research projects—each intended to evaluate paradigm-changing novel tools for prognostic, diagnostic, and therapeutic modalities with defined human endpoints. Project 1 will build on the team’s pioneering work during the current funding cycle that they established as immunomethylomics. The team identified GBM survival to be independently predicted by an interactive model of age and peripheral blood immune profiles, a methylation biomarker of myeloid-derived suppressor cells, or a methylation biomarker of dexamethasone response. Using prospectively collected >1,800 samples from the current cycle and additional samples from the new cycle, the team plans to create blood DNA methylation-based biomarkers for integrated GBM prognosis models, stratification of isocitrate dehydrogenase (IDH)-wild type vs. mutant gliomas, and assessments of treatment response. Project 2 team will also build on their achievements during the current funding cycle related to the development of hyperpolarized C-13 imaging as novel imaging markers of response. In the current proposal, the team will evaluate their central hypothesis that the use of hyperpolarized C-13 (HP) imaging probes (HP [2-13C]pyruvate or [1-13C]α-ketoglutarate [α-KG]) in magnetic resonance (MR) imaging will serve as metabolic markers of treatment response and tumor burden in patients with IDH-mutant glioma. The team will first evaluate their hypothesis in preclinical models and the roles of HP [2-13C ] pyruvate and HP [1- 13C]⍺-KG probes in the treatment response and tumor burden, respectively, in patients. Project 3 will develop the first-in-human phase I trial of adoptive transfer therapy using autologous T lymphocytes that are genetically engineered with a novel “prime and kill” gene circuit. Based on preclinical data, this approach will allow us to overcome significant challenges for developing effective immunotherapy for GBM, such as antigen- heterogeneity, on-target off-tumor toxicities, exhaustion, and the lack of effective GBM-homing of the therapeutic T lymphocytes. This SPORE proposal also requests continued support for the Career Enhancement and Developmental Research Programs and for three Cores (Administrative, Biospecimen/Pathology, and Biostatistics and Clinical) that will support the efforts of the three projects. The research proposed here has significant potential to change how we detect, diagnose, and treat brain cancer.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $2,337,554 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Cancer Centers Support Grants	002	22	8/28/2024	NON-COMPETING CONTINUATION	$2,337,554
2024	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Cancer Centers Support Grants	001	21	5/1/2024	COMPETING CONTINUATION	$22,933
2024	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Cancer Centers Support Grants	000	20	5/1/2024	NON-COMPETING CONTINUATION	-$22,933
														Subtotal = $2,337,554

Issue Date FY: 2023 ( Subtotal = $2,316,634 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	001	21	9/5/2023	COMPETING CONTINUATION	$2,316,634
2023	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	000	20	5/2/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,316,634

Issue Date FY: 2022 ( Subtotal = $2,305,947 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	001	20	9/13/2022	NON-COMPETING CONTINUATION	$2,255,947
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	002	20	9/22/2022	NON-COMPETING CONTINUATION	$50,000
2022	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	000	19	4/28/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,305,947

Issue Date FY: 2021 ( Subtotal = $2,324,997 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	001	19	8/20/2021	NON-COMPETING CONTINUATION	$2,324,997
2021	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	000	18	3/19/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,324,997

Issue Date FY: 2020 ( Subtotal = $2,375,000 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	001	18	8/14/2020	NON-COMPETING CONTINUATION	$2,375,000
2020	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	000	17	3/11/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,375,000

Issue Date FY: 2019 ( Subtotal = $2,322,633 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	002	17	8/20/2019	NON-COMPETING CONTINUATION	$2,322,633
2019	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	001	16	1/28/2019	COMPETING CONTINUATION	$3,871
2019	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	000	15	1/28/2019	NON-COMPETING CONTINUATION	-$3,871
														Subtotal = $2,322,633

Issue Date FY: 2018 ( Subtotal = $2,498,496 )
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	000	16	9/6/2018	COMPETING CONTINUATION	$2,498,496
														Subtotal = $2,498,496

Issue Date FY: 2017 ( Subtotal = $2,299,520 )
2017	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Cancer Centers Support Grants	003	15	8/11/2017	NON-COMPETING CONTINUATION	$2,184,999
2017	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Cancer Centers Support Grants	004	15	9/21/2017	NON-COMPETING CONTINUATION	$115,001
2017	2016	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Cancer Centers Support Grants	001	14	1/4/2017	EXTENSION WITH OR WITHOUT FUNDS	$605,812
2017	2015	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Cancer Centers Support Grants	000	13	1/4/2017	NON-COMPETING CONTINUATION	-$605,812
2017	2012	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Cancer Centers Support Grants	002	10	5/8/2017	SUPPLEMENT FOR EXPANSION	-$480
														Subtotal = $2,299,520

Issue Date FY: 2016 ( Subtotal = $2,006,093 )
2016	2016	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	000	14	8/16/2016	EXTENSION WITH OR WITHOUT FUNDS	$2,006,093
														Subtotal = $2,006,093

Issue Date FY: 2015 ( Subtotal = $2,185,000 )
2015	2015	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	000	13	8/31/2015	NON-COMPETING CONTINUATION	$2,185,000
														Subtotal = $2,185,000

Issue Date FY: 2014 ( Subtotal = $2,161,996 )
2014	2014	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	000	12	9/2/2014	NON-COMPETING CONTINUATION	$2,161,996
														Subtotal = $2,161,996

Issue Date FY: 2013 ( Subtotal = $2,150,500 )
2013	2013	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	000	11	9/18/2013	COMPETING CONTINUATION	$2,150,500
														Subtotal = $2,150,500

Issue Date FY: 2012 ( Subtotal = $599,883 )
2012	2012	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	000	10	9/21/2012	SUPPLEMENT FOR EXPANSION	$599,883
														Subtotal = $599,883

Issue Date FY: 2011 ( Subtotal = $2,140,227 )
2011	2011	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Research Manpower	001	10	7/19/2011	NON-COMPETING CONTINUATION	$1,013,792
2011	2011	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Research Manpower	000	10	4/15/2011	NON-COMPETING CONTINUATION	$1,126,435
														Subtotal = $2,140,227

Issue Date FY: 2010 ( Subtotal = $2,252,870 )
2010	2010	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Research Manpower	001	9	6/23/2010	NON-COMPETING CONTINUATION	$2,252,870
2010	2009	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Research Manpower	000	8	10/30/2009	NON-COMPETING CONTINUATION	$0
2010	2007	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Centers Support Grants	002	6	7/12/2010	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $2,252,870

Issue Date FY: 2009 ( Subtotal = $2,252,868 )
2009	2009	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Research Manpower	000	8	7/1/2009	NON-COMPETING CONTINUATION	$2,252,868
														Subtotal = $2,252,868

Issue Date FY: 2008 ( Subtotal = $2,327,870 )
2008	2008	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Cancer Research Manpower	000	7	6/2/2008	NON-COMPETING CONTINUATION	$2,327,870
														Subtotal = $2,327,870

Grand Total All Awards = $49,195,262

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Brain Tumor SPORE Grant

Award Number: P50CA097257

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/20/2002

PERIOD OF PERFORMANCE END DATE: 08/31/2028

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