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FCCC-PENN SPORE IN OVARIAN CANCER

Award Number: P50CA083638
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/1999
PERIOD OF PERFORMANCE END DATE: 05/31/2015

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FCCC-PENN SPORE IN OVARIAN CANCER - The Fox Chase Cancer Center (FCCC) and the University of Pennsylvania (PENN) Ovarian SPORE is submitted as a partnership between two Philadelphia NCI Cancer Centers requesting support for years 11 through 15 of this SPORE. Over the last 9 years the SPORE program has matured and evolved. Viewing the SPORE today, the notable difference in the new submission has been the recruitment of new and energetic leadership to the SPORE bringing new ideas, technologies, and institutional investment. This translational focus is a benefit of both the SPORE Program's maturity, the depth of research in ovarian cancer at the institutions, as well as nearly unique institutional resources that catalyzed the expansion of the ovarian cancer program at FCCC-PENN. Within the new SPORE are five highly translational Projects. The projects include: PI) Gene Methylation Signatures for Predictive Classification of Response to Therapy; P2) Improving the Estimation and Communication of Ovarian Cancer Risk among BRCA1/2 Carriers to Optimize Decision Making; P3) Therapeutic Micro RNA Strategies for Ovarian Cancer; P4) Targeting Signaling Networks via Novel RNAi Approaches to Improve Therapy for Ovarian Cancer; P5) Advancing T cell Therapy for Ovarian Cancer. The Programs are supported by three separate cores including an Administrative, Biospecimen and Tissue Procurement, and a Biostatistics and Bioinformatics Cores. The SPORE also has a highly effective Career Development Program and a Developmental Pilot Project Program which has been successful at launching the career of many junior investigators and has served to identify new Projects through the first ten years of the SPORE. The investment in the SPORE and the FCCC-PENN Ovarian Cancer Program between 2004 and 2014 comes through direct investments in the SPORE ($6.2 million), with another $10.9 million into the ovarian cancer programs and faculty at PENN and FCCC. In addition, the two NCI Cancer Centers have provided an additional $13.4 million in associated yet important investments supporting the gynecologic oncology clinical and research infrastructure. In addition, over 10 million dollars in collateral and follow on grants have been generated from FCCC-PENN Ovarian SPORE research in the last five years thus bringing the total ovarian cancer (but non-SPORE) investment into the ovarian cancer programs and infrastructure to over 41 million dollars.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2013 ( Subtotal = $2,130,912 )
2013	2013	INSTITUTE FOR CANCER RESEARCH	333 Cottman Ave	Philadelphia	PA	19111	PHILADELPHIA	USA	Cancer Centers Support Grants	000	15	6/13/2013	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$2,050,419
2013	2013	INSTITUTE FOR CANCER RESEARCH	333 Cottman Ave	Philadelphia	PA	19111	PHILADELPHIA	USA	Cancer Centers Support Grants	001	15	8/2/2013	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$80,493
														Subtotal = $2,130,912

Issue Date FY: 2012 ( Subtotal = $2,300,000 )
2012	2012	FOX CHASE CANCER CENTER	333 Cottman Ave	Philadelphia	PA	19111	PHILADELPHIA	USA	Cancer Centers Support Grants	001	14	9/20/2012	NON-COMPETING CONTINUATION	$575,000
2012	2012	FOX CHASE CANCER CENTER	333 Cottman Ave	Philadelphia	PA	19111	PHILADELPHIA	USA	Cancer Centers Support Grants	000	14	5/24/2012	NON-COMPETING CONTINUATION	$1,725,000
														Subtotal = $2,300,000

Issue Date FY: 2011 ( Subtotal = $2,185,000 )
2011	2011	FOX CHASE CANCER CENTER	333 Cottman Ave	Philadelphia	PA	19111	PHILADELPHIA	USA	Cancer Centers Support Grants	000	13	7/20/2011	NON-COMPETING CONTINUATION	$2,185,000
														Subtotal = $2,185,000

Issue Date FY: 2010 ( Subtotal = $2,300,000 )
2010	2010	FOX CHASE CANCER CENTER	333 Cottman Ave	Philadelphia	PA	19111	PHILADELPHIA	USA	Cancer Centers Support Grants	001	12	8/3/2010	NON-COMPETING CONTINUATION	$2,300,000
2010	2009	FOX CHASE CANCER CENTER	7701 BURHOLME AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Cancer Centers Support Grants	000	11	10/26/2009	COMPETING CONTINUATION	$0
														Subtotal = $2,300,000

Issue Date FY: 2009 ( Subtotal = $2,300,000 )
2009	2009	FOX CHASE CANCER CENTER	333 Cottman Ave	Philadelphia	PA	19111	PHILADELPHIA	USA	Cancer Centers Support Grants	002	11	8/21/2009	COMPETING CONTINUATION	$2,300,000
2009	2009	FOX CHASE CANCER CENTER	7701 BURHOLME AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Cancer Centers Support Grants	003	11	10/26/2009	COMPETING CONTINUATION	$0
2009	2008	FOX CHASE CANCER CENTER	7701 BURHOLME AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Cancer Centers Support Grants	000	10	8/27/2009	NON-COMPETING CONTINUATION	$0
2009	2008	FOX CHASE CANCER CENTER	7701 BURHOLME AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Cancer Centers Support Grants	001	10	9/15/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,300,000

Issue Date FY: 2008 ( Subtotal = $2,137,351 )
2008	2008	FOX CHASE CANCER CENTER	7701 BURHOLME AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Cancer Centers Support Grants	000	10	8/1/2008	NON-COMPETING CONTINUATION	$2,137,351
														Subtotal = $2,137,351

Issue Date FY: 2007 ( Subtotal = $2,222,851 )
2007	2007	FOX CHASE CANCER CENTER	7701 BURHOLME AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Cancer Centers Support Grants	000	9	8/7/2007	NON-COMPETING CONTINUATION	$2,222,851
														Subtotal = $2,222,851

Issue Date FY: 2006 ( Subtotal = $2,308,479 )
2006	2006	FOX CHASE CANCER CENTER	7701 BURHOLME AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Cancer Centers Support Grants	000	8	9/15/2006	NON-COMPETING CONTINUATION	$2,308,479
														Subtotal = $2,308,479

Issue Date FY: 2005 ( Subtotal = $2,412,603 )
2005	2005	FOX CHASE CANCER CENTER	7701 BURHOLME AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Cancer Centers Support Grants	000	7	8/23/2005	NON-COMPETING CONTINUATION	$2,412,603
														Subtotal = $2,412,603

Issue Date FY: 2004 ( Subtotal = $1,887,484 )
2004	2004	FOX CHASE CANCER CENTER	7701 BURHOLME AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Cancer Centers Support Grants	001	6	9/23/2004	SUPPLEMENT FOR EXPANSION	$162,484
2004	2004	FOX CHASE CANCER CENTER	7701 BURHOLME AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Cancer Centers Support Grants	000	6	9/22/2004	COMPETING CONTINUATION	$1,725,000
														Subtotal = $1,887,484

Issue Date FY: 2003 ( Subtotal = $3,100,910 )
2003	2003	FOX CHASE CANCER CENTER	7701 BURHOLME AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Indicates awards funded from multiple programs	000	5	9/29/2003	NON-COMPETING CONTINUATION	$3,100,910
														Subtotal = $3,100,910

Issue Date FY: 2002 ( Subtotal = $3,261,477 )
2002	2002	FOX CHASE CANCER CENTER	7701 BURHOLME AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Indicates awards funded from multiple programs	000	4	9/27/2002	NON-COMPETING CONTINUATION	$3,261,477
														Subtotal = $3,261,477

Issue Date FY: 2001 ( Subtotal = $2,969,507 )
2001	2001	FOX CHASE CANCER CENTER	7701 BURHOLME AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Cancer Centers Support Grants	000	3	9/26/2001	NON-COMPETING CONTINUATION	$2,969,507
														Subtotal = $2,969,507

Issue Date FY: 2000 ( Subtotal = $2,055,985 )
2000	2000	FOX CHASE CANCER CENTER	7701 BURHOLME AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Cancer Centers Support Grants	000	2	9/14/2000	NON-COMPETING CONTINUATION	$2,043,985
2000	2000	FOX CHASE CANCER CENTER	7701 BURHOLME AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Cancer Centers Support Grants	001	1	6/12/2000	SUPPLEMENT FOR EXPANSION	$12,000
														Subtotal = $2,055,985

Issue Date FY: 1999 ( Subtotal = $1,156,886 )
1999	1999	FOX CHASE CANCER CENTER	7701 BURHOLME AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Cancer Centers Support Grants	000	1	9/30/1999	NEW	$1,156,886
														Subtotal = $1,156,886

Grand Total All Awards = $34,729,445

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FCCC-PENN SPORE IN OVARIAN CANCER

Award Number: P50CA083638

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/1999

PERIOD OF PERFORMANCE END DATE: 05/31/2015

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