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Oklahoma Sjogren's Syndrome Center of Research Translation

Award Number: P50AR060804
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/21/2011
PERIOD OF PERFORMANCE END DATE: 06/30/2017

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Oklahoma Sjogren's Syndrome Center of Research Translation - DESCRIPTION (provided by applicant): Sjogren's syndrome (SS) is a chronic, progressive autoimmune disorder characterized by lymphocytic infiltration ofthe exocrine glands that leads to severe oral and ocular dryness. SS is also a systemic disease that may include debilitating fatigue, lymphoma, neuropathies, pulmonary disease, and arthralgias. The etiology of SS is poorly understood, but clearly involves a complex genetic architecture influenced by environmental factors that lead to abnormal cellular and humoral immune responses. The difficulty in correctly diagnosing SS in addition to the scarcity of effective therapeutic options, often results in significant morbidity and irreversible damage to the exocrine glands. We propose to implement the resources and administrative structure to facilitate the translation of laboratory-based research in Sjogren's syndrome into relevant diagnostic, prognostic and therapeutic innovations in the field of autoimmune disease. The Oklahoma Sjogren's Syndrome Center of Research Translation (OSSCORT) will have the unique opportunity to bring together a strong core of well-funded laboratory-based scientists and clinical researchers at the Oklahoma Medical Research Foundation, with a multidisciplinary network of investigators committed to Sjogren's Syndrome Research from of the University of Oklahoma Health Sciences Center and multiple US and international sites. The OSSCORT will initially consist of three Projects and three Cores, and will in the successive years expand to include Pilot and Feasibility Projects, as well as an Enrichment Program. Project 1 will address the genetics of SS by applying state-of-the-art genome wide association and replication experiments, as well as genotypic delineation of sub-phenotypes. Project 2 will develop innovative approaches to reveal key features of T cell immune dysregulation in Sjogren's syndrome, and Project 3 will utilize a humanized mouse model of SS to test the hypothesis that B cells infiltrating the salivary glands of patients make autoantibodies that are in part responsible for the exocrine glandular dysfunction. The Cores that will assist and facilitate the OSSCORT are an Administrative Core, a Clinical Core and a Data Analysis and Bioinformatics Core led by experienced leaders in the field. RELEVANCE: We are witnesses of an increasing need to translate the relevant discoveries of laboratory-based research into clinically relevant results. The OSSCORT has the unique combination of clinical, scientific and administrative resources to improve understanding of the pathogenesis of SS. This will in turn create opportunities for new diagnostics, prognostic and therapeutic strategies that will benefit patients with this and other related diseases.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2018 ( Subtotal = -$503 )
2018	2015	OKLAHOMA MEDICAL RESEARCH FOUNDATION	825 NE 13TH ST	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	5	11/17/2017	NON-COMPETING CONTINUATION	-$503
														Subtotal = -$503

Issue Date FY: 2015 ( Subtotal = $1,607,608 )
2015	2015	OKLAHOMA MEDICAL RESEARCH FOUNDATION	825 NE 13TH STREET	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	5	9/2/2015	NON-COMPETING CONTINUATION	$1,607,608
														Subtotal = $1,607,608

Issue Date FY: 2014 ( Subtotal = $1,610,869 )
2014	2014	OKLAHOMA MEDICAL RESEARCH FOUNDATION	825 NE 13TH STREET	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	4	7/23/2014	NON-COMPETING CONTINUATION	$1,610,869
														Subtotal = $1,610,869

Issue Date FY: 2013 ( Subtotal = $1,533,283 )
2013	2013	OKLAHOMA MEDICAL RESEARCH FOUNDATION	825 NE 13TH STREET	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	8/1/2013	NON-COMPETING CONTINUATION	$1,533,283
														Subtotal = $1,533,283

Issue Date FY: 2012 ( Subtotal = $1,550,076 )
2012	2012	OKLAHOMA MEDICAL RESEARCH FOUNDATION	825 NE 13TH STREET	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	6/15/2012	NON-COMPETING CONTINUATION	$1,550,076
														Subtotal = $1,550,076

Issue Date FY: 2011 ( Subtotal = $1,624,533 )
2011	2011	OKLAHOMA MEDICAL RESEARCH FOUNDATION	825 NE 13TH STREET	OKLAHOMA CITY	OK	73104	OKLAHOMA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	7/21/2011	NEW	$1,624,533
														Subtotal = $1,624,533

Grand Total All Awards = $7,925,866

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Oklahoma Sjogren's Syndrome Center of Research Translation

Award Number: P50AR060804

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/21/2011

PERIOD OF PERFORMANCE END DATE: 06/30/2017

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