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Pathogenesis, Carcinogenesis and Ecology of Opisthorchiasis in Thailand

Award Number: P50AI098639
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2012
PERIOD OF PERFORMANCE END DATE: 07/31/2017

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Pathogenesis, Carcinogenesis and Ecology of Opisthorchiasis in Thailand - This TMRC application deals with the neglected tropical disease, opisthorchiasis, caused by infection with the fish-borne trematode parasite, Opisthorchis viverrini. Chronic opisthorchiasis often culminates cholangiocarcinoma, cancer of the bile ducts. This TMRC application takes place in Khon Kaen Province, on the Khorat Plateau in northeastern Thailand. The research draws together a diverse team of researchers with expertise in carcinogenesis, molecular and immuno-parasitology, pathogenesis, biostatistics, epidemiology and transmission modeling. The proposed research, which includes three scientific projects and two cores, addresses major gaps in our current understanding of carcinogenesis, host-susceptibility and the ecology of O. viverrini transmission. While our research focuses specifically on O. viverrini, the research has implications for the control of other carcinogenic liver flukes, particularly, Clonorchis sinensis. Together, these parasites infec an estimated 45 million people in Southeast Asia, China and the Koreas, with infections and associated malignancies concentrated in the rural poor. The proposal includes three scientific projects and two cores. The scientific goals of this TMRC involve characterizing human phenotypic markers displayed by infected humans who are at risk of cholangiocarcinoma caused by O. viverrini. In particular, we will compare and contrast immunological and inflammatory profiles of individuals whose liver (periportal) fibrosis do or does not resolve after medication with praziquantel to remove the parasite infection. These comparisons can be predicted to deliver markers that predict progression to advanced liver fibrosis and indeed cholangiocarcinoma from among the millions of persons infected with O. viverrini, and perhaps also from the many millions more infected with related liver flukes, including Clonorchis sinensis in Vietnam, China and the Koreas.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2018 ( Subtotal = -$2,174 )
2018	2016	KHON KAEN UNIVERSITY	123 MITTRAPARP ROAD	MUANG	KHON KAEN	40002		THA	Allergy and Infectious Diseases Research	000	5	5/2/2018	NON-COMPETING CONTINUATION	-$2,174
														Subtotal = -$2,174

Issue Date FY: 2016 ( Subtotal = $307,383 )
2016	2016	KHON KAEN UNIVERSITY	OFFICE OF RESEARCH ADMINISTRATION K	MUANG				THA	Allergy and Infectious Diseases Research	000	5	8/15/2016	NON-COMPETING CONTINUATION	$307,383
														Subtotal = $307,383

Issue Date FY: 2015 ( Subtotal = $307,383 )
2015	2015	KHON KAEN UNIVERSITY	OFFICE OF RESEARCH ADMINISTRATION K	MUANG				THA	Allergy and Infectious Diseases Research	000	4	7/17/2015	NON-COMPETING CONTINUATION	$307,383
														Subtotal = $307,383

Issue Date FY: 2014 ( Subtotal = $307,383 )
2014	2014	KHON KAEN UNIVERSITY	OFFICE OF RESEARCH ADMINISTRATION K	MUANG				THA	Allergy and Infectious Diseases Research	000	3	8/29/2014	NON-COMPETING CONTINUATION	$307,383
														Subtotal = $307,383

Issue Date FY: 2013 ( Subtotal = $342,515 )
2013	2013	KHON KAEN UNIVERSITY	OFFICE OF RESEARCH ADMINISTRATION K	MUANG				THA	Allergy and Infectious Diseases Research	003	2	8/14/2013	EXTENSION WITH OR WITHOUT FUNDS	$53,575
2013	2013	KHON KAEN UNIVERSITY	OFFICE OF RESEARCH ADMINISTRATION K	MUANG				THA	Allergy and Infectious Diseases Research	001	2	8/1/2013	EXTENSION WITH OR WITHOUT FUNDS	$288,940
2013	2012	KHON KAEN UNIVERSITY	OFFICE OF RESEARCH ADMINISTRATION K	MUANG				THA	Allergy and Infectious Diseases Research	000	1	3/8/2013	NEW	$53,575
2013	2012	KHON KAEN UNIVERSITY	OFFICE OF RESEARCH ADMINISTRATION K	MUANG				THA	Allergy and Infectious Diseases Research	002	1	8/13/2013	NEW	-$53,575
														Subtotal = $342,515

Issue Date FY: 2012 ( Subtotal = $312,883 )
2012	2012	KHON KAEN UNIVERSITY	OFFICE OF RESEARCH ADMINISTRATION K	MUANG				THA	Allergy and Infectious Diseases Research	002	1	9/24/2012	NEW	$1,073
2012	2012	KHON KAEN UNIVERSITY	OFFICE OF RESEARCH ADMINISTRATION K	MUANG				THA	Allergy and Infectious Diseases Research	000	1	6/20/2012	NEW	$311,810
2012	2012	KHON KAEN UNIVERSITY	123 MITTRAPARP ROAD	KHON KAEN				THA	Allergy and Infectious Diseases Research	001	1	6/21/2012	NEW	$0
														Subtotal = $312,883

Grand Total All Awards = $1,575,373

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Pathogenesis, Carcinogenesis and Ecology of Opisthorchiasis in Thailand

Award Number: P50AI098639

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2012

PERIOD OF PERFORMANCE END DATE: 07/31/2017

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