Monday, June 30, 2025 6/30/2025

Cutaneous Leishmaniasis in West Africa: the Parasite, Vector and Disease

Award Number: P50AI098505
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2012
PERIOD OF PERFORMANCE END DATE: 07/31/2018

Group Awards By:

View Award Description

Cutaneous Leishmaniasis in West Africa: the Parasite, Vector and Disease - DESCRIPTION (provided by applicant): Cutaneous leishmaniasis (CL) has a long history in West Africa, but one of the less recognized parasitic infections in the region. The disease is endemic Saharan desert countries in the North, in Sahelian band from west to East Africa. Currently, there is no vaccine against the diseases. However, studies have consistently shown that sand fly saliva generally enhances infectivity of Leishmania parasites in a naive host while an adaptive immune response to whole saliva or a distinct salivary protein generally protects against both cutaneous and visceral leishmaniasis in rodent models of infection. In the proposed work, 3 sites in West Africa each with distinct epidemiological and ecological environment will be compared with regard to intensity and prevalence of cutaneous leishmania infection, sand fly vector population dynamics, and disease pathogenesis with a focus on parasite and host factors and the immune response to candidate vaccines (sand fly proteins in particular). The hypothesis underlying this proposal is that a combination of parasite, vector, and human exposure to other parasitic infection such as infection with microfilariae determine the immunomodulatory effects of candidate vaccines, specifically sand fly proteins. The proposal seeks to 1] understand the basic epidemiology of cutaneous leishmaniasis and its vector in different foci of West Africa; 2] understand mechanism of resistance/susceptibility to the disease; 3] assess how an active infection with microfilariae alters the human immune response to sand fly salivary proteins and 4] reinforce local research capacity for future vaccine trials. RELEVANCE: This proposal is directly relevant to public health because Leishmaniasis take an enormous toll across the globe. Its goals are to examine the epidemiology, transmission of cutaneous leishmaniasis and a component that has been largely overlooked: the immuno-modulation of sandfly proteins. Project 1: Epidemiology of Cutaneous Leishmaniasis Project Leader: Ousmane Faye, MD, PhD (Description as provided by applicant): Leishmaniasis is a vector-borne disease transmitted to the host via the bite of a Leishmania infected phlebotomine sand fly. Cutaneous leishmaniasis (CL) has a long history in West Africa, but is one of the less recognized parasitic infections in the region. Studies have consistently shown that sand fly saliva generally enhances infectivity of Leishmania parasites in a naive host while an adaptive immune response to whole saliva or a distinct salivary protein generally protects against both cutaneous and visceral leishmaniasis in rodent models of infection. In the proposed work, three sites in West Africa each with distinct epidemiological and ecological environment will be compared with regard to intensity and prevalence of cutaneous leishmania infection, sand fly vector population dynamics, and disease pathogenesis with a focus on parasite and host factors and the immune response to candidate vaccines (sand fly proteins in particular). This project seeks to 1] Determine the prevalence/incidence (of infection and disease) of CL and characterize the Leishmania parasites circulating in Malian and Ghanaian classical and cryptic foci of CL; 2] Correlate specific human immune responses to sand fly salivary proteins with CL outcome. In the Aim 1 we will possibly characterize new species of Leishmania parasites from a site where the infected individuals presented with asymptomatic CL and compare it to a classical CL focus. We will also in Aim 2, for the first time, establish if sand fly salivary cellular immunity can influece the CL outcome in endemic populations. RELEVANCE: This project is at the center of the entire proposal because it will assess the relationship between human exposure to sand fly vector bite (Project 2), the parasite and immune response to sand fly salivary proteins (Project 3) and the disease. Understanding of these relationship is important for vaccine development and field trials of control strategies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = -$57,738 )
2022	2016	UNIVERSITE DES SCIENCES, DES TECHNIQUES ET DES TECHNOLOGIES DE BAMAKO USTTB	HAMDALLAYE ACI 2000	BAMAKO				MLI	Allergy and Infectious Diseases Research	000	5	10/1/2021	NON-COMPETING CONTINUATION	-$57,738
														Subtotal = -$57,738

Issue Date FY: 2021 ( Subtotal = -$37,071 )
2021	2016	UNIVERSITE DES SCIENCES, DES TECHNIQUES ET DES TECHNOLOGIES DE BAMAKO USTTB	HAMDALLAYE ACI 2000	BAMAKO				MLI	Allergy and Infectious Diseases Research	000	5	10/1/2020	NON-COMPETING CONTINUATION	-$37,071
2021	2016	UNIVERSITE DES SCIENCES, DES TECHNIQUES ET DES TECHNOLOGIES DE BAMAKO USTTB	HAMDALLAYE ACI 2000	BAMAKO				MLI	Allergy and Infectious Diseases Research	001	5	10/3/2020	NON-COMPETING CONTINUATION	$37,071
2021	2016	UNIVERSITE DES SCIENCES, DES TECHNIQUES ET DES TECHNOLOGIES DE BAMAKO USTTB	HAMDALLAYE ACI 2000	BAMAKO				MLI	Allergy and Infectious Diseases Research	002	5	10/3/2020	NON-COMPETING CONTINUATION	-$37,071
														Subtotal = -$37,071

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2016	UNIVERSITE DES SCIENCES, DES TECHNIQUES ET DES TECHNOLOGIES DE BAMAKO USTTB	HAMDALLAYE ACI 2000	BAMAKO				MLI	Allergy and Infectious Diseases Research	001	5	7/14/2020	NON-COMPETING CONTINUATION	-$57,738
2020	2016	UNIVERSITE DES SCIENCES, DES TECHNIQUES ET DES TECHNOLOGIES DE BAMAKO USTTB	HAMDALLAYE ACI 2000	BAMAKO				MLI	Allergy and Infectious Diseases Research	003	5	7/29/2020	NON-COMPETING CONTINUATION	$57,738
2020	2015	UNIVERSITE DES SCIENCES, DES TECHNIQUES ET DES TECHNOLOGIES DE BAMAKO USTTB	HAMDALLAYE ACI 2000	BAMAKO				MLI	Allergy and Infectious Diseases Research	000	4	7/14/2020	NON-COMPETING CONTINUATION	-$99,112
2020	2015	UNIVERSITE DES SCIENCES, DES TECHNIQUES ET DES TECHNOLOGIES DE BAMAKO USTTB	HAMDALLAYE ACI 2000	BAMAKO				MLI	Allergy and Infectious Diseases Research	002	4	7/29/2020	NON-COMPETING CONTINUATION	$99,112
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = -$312,262 )
2019	2016	UNIVERSITE DES SCIENCES, DES TECHNIQUES ET DES TECHNOLOGIES DE BAMAKO USTTB	HAMDALLAYE ACI 2000	BAMAKO				MLI	Allergy and Infectious Diseases Research	000	5	1/29/2019	NON-COMPETING CONTINUATION	-$312,262
														Subtotal = -$312,262

Issue Date FY: 2016 ( Subtotal = $370,000 )
2016	2016	UNIVERSITY OF MALI	Campus de Badalabougou	BAMAKO				MLI	Allergy and Infectious Diseases Research	000	5	7/19/2016	NON-COMPETING CONTINUATION	$370,000
														Subtotal = $370,000

Issue Date FY: 2015 ( Subtotal = $370,000 )
2015	2015	UNIVERSITY OF MALI	Campus de Badalabougou	BAMAKO				MLI	Allergy and Infectious Diseases Research	000	4	7/15/2015	NON-COMPETING CONTINUATION	$370,000
														Subtotal = $370,000

Issue Date FY: 2014 ( Subtotal = $370,000 )
2014	2014	UNIVERSITY OF MALI	Campus de Badalabougou	BAMAKO				MLI	Allergy and Infectious Diseases Research	000	3	7/22/2014	NON-COMPETING CONTINUATION	$370,000
														Subtotal = $370,000

Issue Date FY: 2013 ( Subtotal = $347,799 )
2013	2013	UNIVERSITY OF MALI	Campus de Badalabougou	BAMAKO				MLI	Allergy and Infectious Diseases Research	000	2	7/29/2013	EXTENSION WITH OR WITHOUT FUNDS	$347,799
														Subtotal = $347,799

Issue Date FY: 2012 ( Subtotal = $300,000 )
2012	2012	UNIVERSITY OF BAMAKO	POST OFFICE BOX 1805	BAMAKO					Allergy and Infectious Diseases Research	001	1	7/25/2012	NEW	$0
2012	2012	UNIVERSITY OF BAMAKO	POST OFFICE BOX 1805	BAMAKO					Allergy and Infectious Diseases Research	002	1	8/21/2012	NEW	$0
2012	2012	UNIVERSITY OF MALI	Campus de Badalabougou	BAMAKO				MLI	Allergy and Infectious Diseases Research	000	1	7/24/2012	NEW	$300,000
														Subtotal = $300,000

Grand Total All Awards = $1,350,728

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Cutaneous Leishmaniasis in West Africa: the Parasite, Vector and Disease

Award Number: P50AI098505

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2012

PERIOD OF PERFORMANCE END DATE: 07/31/2018

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer