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Key Determinants Of The Natural History Of Leishmania major Infection

Award Number: P50AI074178
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2007
PERIOD OF PERFORMANCE END DATE: 07/31/2015

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Key Determinants Of The Natural History Of Leishmania major Infection - Zoonotic Cutaneous Leishmaniasis (ZCL) is a disease highly prevalent in North Africa and Middle East that is caused by Leishmania major. The TMRC program has three main goals :1-Describe the natural history of L. major infection as expressed in an endemic area especially with regard to asymptomatic infection .disease severity and risk of disease recurrence; 2-Analyse the respective roles of factors specific of the vector(sand fly saliva ),or the parasite(intraspecies polymorphism) or the host immune response(innate or adaptative), in the clinical expression of ZCL with special emphasis on the identification of immune correlates of protection against primoinfection, disease occurrence or recurrence; 3-Reinforce the application of Good Epidemiological Clinical and Laboratory Practices at all levels of programme implementation. In order to reach these goals, we shall conduct a large clinical prospective survey in a region endemic for ZCL. All enrolled individuals will be extensively investigated, clinically and immunologically, in order to accurately define their clinical history with regard to leishmania infection (including LST reactivity) as well as their in vitro immune responses to vector saliva components and parasite antigens at baseline Then an active detection of all ZCL cases, that will emerge among the cohort members will be conducted during the two following years .Leishmania isolates that could be grown from active lesions will be extensively investigated at the functional level in order to identify intraspecies diversity due to differential expression of virulence factors. The study will draw a picture of the natural history of L major infection in the region. In addition the clinical, immunological and parasitological informations generated by the program will be integrated into a multiparametric analysis. This will permit to identify immune correlates of protection that take into consideration the eventual effects of intraspecies functional polymorphism of L major and reservoir diversity. These data are of crucial importance for the development and evaluation of effective vaccines or antileishmanial drugs.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2016 ( Subtotal = $0 )
2016	2011	INSTITUT PASTEUR DE TUNIS	13 PLACE PASTEUR BP 74	TUNIS		0000		TUN	Allergy and Infectious Diseases Research	000	5	9/28/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2011 ( Subtotal = $442,091 )
2011	2011	INSTITUT PASTEUR DE TUNIS	13 PLACE PASTEUR BP 74	TUNIS				TUN	Allergy and Infectious Diseases Research	001	5	8/24/2011	NON-COMPETING CONTINUATION	$0
2011	2011	INSTITUT PASTEUR DE TUNIS	13, PLACE PASTEUR BP74 TUNIS-BELVED	TUNIS				TUN	Allergy and Infectious Diseases Research	000	5	8/19/2011	NON-COMPETING CONTINUATION	$442,091
														Subtotal = $442,091

Issue Date FY: 2010 ( Subtotal = $494,538 )
2010	2010	INSTITUT PASTEUR DE TUNIS	13, PLACE PASTEUR BP74 TUNIS-BELVED	TUNIS				TUN	Allergy and Infectious Diseases Research	000	4	8/10/2010	NON-COMPETING CONTINUATION	$494,538
														Subtotal = $494,538

Issue Date FY: 2009 ( Subtotal = $502,715 )
2009	2009	INSTITUT PASTEUR DE TUNIS	13, PLACE PASTEUR BP74 TUNIS-BELVED	TUNIS				TUN	Allergy and Infectious Diseases Research	000	3	9/23/2009	NON-COMPETING CONTINUATION	$502,715
														Subtotal = $502,715

Issue Date FY: 2008 ( Subtotal = $489,190 )
2008	2008	INSTITUT PASTEUR DE TUNIS	13 PLACE PASTEUR BP 74	TUNIS				TUN	Allergy and Infectious Diseases Research	000	2	8/18/2008	NON-COMPETING CONTINUATION	$489,190
														Subtotal = $489,190

Issue Date FY: 2007 ( Subtotal = $467,416 )
2007	2007	INSTITUT PASTEUR DE TUNIS	13 PLACE PASTEUR BP 74	TUNIS				TUN	Allergy and Infectious Diseases Research	000	1	8/15/2007	NEW	$467,416
														Subtotal = $467,416

Grand Total All Awards = $2,395,950

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Key Determinants Of The Natural History Of Leishmania major Infection

Award Number: P50AI074178

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2007

PERIOD OF PERFORMANCE END DATE: 07/31/2015

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