Friday, March 14, 2025 3/14/2025

Center for the Translational Neuroscience of Alcoholism

Award Number: P50AA012870
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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CTNA Overall John Krystal, M.D. Abstract The gap between basic research advances and new clinical insights and treatments remains a critical obstacle to progress in the field of alcoholism research. This translational neuroscience mission is the enduring focus of the Center for the Translational Neuroscience of Alcoholism (CTNA). CTNA conducts groundbreaking molecular neuroscience, molecular genetics, functional and chemical neuroimaging, and psychopharmacology studies in the service of providing new insights to bridge the gap between basic and clinical research. This renewal application will study how inhibition of mGluR5 might normalize disturbances in cortico-striatal glutamate signaling arising from upregulation of NMDA-R and, in so doing, attenuate both goal- oriented (model-based learning) and habitual (model-free learning) alcohol consumption in animals and reduce alcohol consumption in human heavy drinkers. In so doing, we propose the first translational neuroscience evaluation of the therapeutic potential of mGluR5 NAM’s, a mechanism that has received intensive preclinical study. Building upon its prior achievements, The CTNA will facilitate transdisciplinary research within projects and across projects and with other alcohol focused initiatives nationally. It will also continue its highly productive Pilot Projects Core that provides an open competitive mechanism to enable the Center to rapidly encompass innovative new research and to engage outstanding investigators new to alcoholism research. CTNA will continue to expand its educational mission, building on the success of the the International Conference on the Applications of Neuroimaging to Alcoholism.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	24	12/30/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $1,741,323 )
2024	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Alcohol Research Programs	001	24	6/28/2024	NON-COMPETING CONTINUATION	$1,741,323
2024	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	23	2/7/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,741,323

Issue Date FY: 2023 ( Subtotal = $1,741,341 )
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Alcohol Research Programs	001	23	5/4/2023	NON-COMPETING CONTINUATION	$1,741,341
2023	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	22	2/14/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,741,341

Issue Date FY: 2022 ( Subtotal = $1,741,345 )
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Alcohol Research Programs	004	22	6/15/2022	NON-COMPETING CONTINUATION	$1,741,345
2022	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Alcohol Research Programs	001	21	10/27/2021	COMPETING CONTINUATION	$747,003
2022	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Alcohol Research Programs	002	21	1/24/2022	COMPETING CONTINUATION	$0
2022	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Alcohol Research Programs	003	21	2/9/2022	COMPETING CONTINUATION	$0
2022	2020	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	20	10/27/2021	NON-COMPETING CONTINUATION	-$747,003
														Subtotal = $1,741,345

Issue Date FY: 2021 ( Subtotal = $1,765,263 )
2021	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Alcohol Research Programs	001	21	6/9/2021	COMPETING CONTINUATION	$1,765,263
2021	2020	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	20	4/29/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,765,263

Issue Date FY: 2020 ( Subtotal = $1,672,583 )
2020	2020	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Alcohol Research Programs	001	20	5/21/2020	NON-COMPETING CONTINUATION	$1,672,583
2020	2019	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	19	5/12/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,672,583

Issue Date FY: 2019 ( Subtotal = $1,671,647 )
2019	2019	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Alcohol Research Programs	001	19	6/3/2019	NON-COMPETING CONTINUATION	$1,671,647
2019	2018	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	18	1/31/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,671,647

Issue Date FY: 2018 ( Subtotal = $1,671,773 )
2018	2018	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	18	5/15/2018	NON-COMPETING CONTINUATION	$1,671,773
														Subtotal = $1,671,773

Issue Date FY: 2017 ( Subtotal = $1,671,131 )
2017	2017	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	17	5/31/2017	NON-COMPETING CONTINUATION	$1,671,131
														Subtotal = $1,671,131

Issue Date FY: 2016 ( Subtotal = $1,672,144 )
2016	2016	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	16	5/23/2016	COMPETING CONTINUATION	$1,672,144
														Subtotal = $1,672,144

Issue Date FY: 2015 ( Subtotal = $1,576,891 )
2015	2015	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Alcohol Research Programs	001	15	9/22/2015	SUPPLEMENT FOR EXPANSION	$86,562
2015	2015	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	15	5/8/2015	NON-COMPETING CONTINUATION	$1,490,329
														Subtotal = $1,576,891

Issue Date FY: 2014 ( Subtotal = $1,523,916 )
2014	2014	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	14	6/4/2014	NON-COMPETING CONTINUATION	$1,523,916
														Subtotal = $1,523,916

Issue Date FY: 2013 ( Subtotal = $1,493,582 )
2013	2013	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	13	5/31/2013	NON-COMPETING CONTINUATION	$1,493,582
														Subtotal = $1,493,582

Issue Date FY: 2012 ( Subtotal = $1,586,434 )
2012	2012	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Alcohol Research Programs	000	12	5/8/2012	NON-COMPETING CONTINUATION	$1,586,434
														Subtotal = $1,586,434

Issue Date FY: 2011 ( Subtotal = $1,624,900 )
2011	2011	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Alcohol Research Programs	003	11	8/12/2011	COMPETING CONTINUATION	$0
2011	2011	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Alcohol Research Programs	002	11	8/5/2011	COMPETING CONTINUATION	$3,466
2011	2011	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Alcohol Research Programs	001	11	7/15/2011	COMPETING CONTINUATION	$1,621,434
2011	2010	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Alcohol Research Center Grants	000	10	7/13/2011	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,624,900

Issue Date FY: 2010 ( Subtotal = $1,380,423 )
2010	2010	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Alcohol Research Center Grants	000	10	6/1/2010	NON-COMPETING CONTINUATION	$1,269,303
2010	2010	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Trans-NIH Recovery Act Research Support	001	10	8/20/2010	SUPPLEMENT FOR EXPANSION	$111,120
														Subtotal = $1,380,423

Issue Date FY: 2009 ( Subtotal = $1,284,826 )
2009	2009	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Alcohol Research Center Grants	001	9	7/2/2009	NON-COMPETING CONTINUATION	$1,284,826
2009	2008	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Alcohol Research Center Grants	000	8	5/26/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,284,826

Issue Date FY: 2008 ( Subtotal = $1,276,840 ) (Continued on the next page)
Grand Total All Awards = $38,867,132

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Center for the Translational Neuroscience of Alcoholism

Award Number: P50AA012870

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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