Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Southern California Superfund Research and Training Program for PFAS Assessment, Remediation, and Prevention (ShARP)

Award Number: P42ES036506
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/24/2025
PERIOD OF PERFORMANCE END DATE: 01/31/2030

Group Awards By:

View Award Description

Southern California Superfund Research and Training Program for PFAS Assessment, Remediation, and Prevention (ShARP) - The overall goal of Southern California Superfund Research and Training Program for PFAS Assessment, Remediation, and Prevention (ShARP) is to develop problem-based, solution-oriented scientific knowledge and innovative technologies to address the issue of poly- and perfluoroalkyl substances (PFAS) water contamination in Superfund and other sites. PFAS are a class of persistent and ubiquitous chemicals contaminating more than 3,000 sites across the U.S., including at least 245 EPA-identified Superfund sites. PFAS exposure can affect liver health and partly explain the excess burden of metabolic dysfunction-associated steatotic liver disease (MASLD) in the U.S. We will strengthen the Superfund Research Program (SRP) and complement current SRP Centers by establishing the first Center that specifically addresses PFAS in relation to their effects on liver disease. The Center will lead four highly interactive Research Projects that integrate biomedical and environmental engineering research related to the SRP mandates with the following objectives: (1) Develop advanced techniques to evaluate the effect of PFAS on liver disease (MANDATE 1) and the molecular mechanisms of PFAS hepatotoxicity (MANDATE 2) in human 3D liver spheroid models (PROJECT 1) and in human longitudinal studies (PROJECT 2); (2) Develop novel PFAS characterization techniques on samples from environmental reservoirs (water, soil, and air) and a predictive PFAS groundwater model for mobilization of PFAS plumes from a PFAS-contaminated Superfund site because of groundwater recharge (MANDATE 3/PROJECT 3); and (3) Develop advanced processes for microbial, chemical, and thermal defluorination to allow definitive PFAS treatment, with application to Superfund sites (MANDATE 4/PROJECT 4). The Research Programs are led by collaborative multidisciplinary teams and supported by four Cores: The Community Engagement Core (CEC) will foster communication and support the translation of Center research findings to inform prevention strategies. The Data Management and Analysis Core (DMAC) will optimize the use of the complex data generated by the research projects and serves as an incubator to accelerate cross-project integration and discoveries. The Research Experience and Training Coordination Core (RETCC) will support the training of the next generation of scientists in environmental health and engineering, translational research and key stakeholders’ engagement. The Administrative Core supports the translation of the Center’s research findings to key SRP end-users. In summary, our system-based integrated approaches, the central role of the stakeholders, the strong institutional support, and our team’s successful experience working together, will enable us to address urgent concerns regarding water quality and human health in populations affected by PFAS exposures and Superfund sites.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $3,269,842 )
2026	2026	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	2	1/27/2026	NON-COMPETING CONTINUATION	$1,632,021
2026	2026	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	2	3/3/2026	NON-COMPETING CONTINUATION	$1,637,821
														Subtotal = $3,269,842

Issue Date FY: 2025 ( Subtotal = $1,632,021 )
2025	2025	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	1	4/23/2025	NEW	$1,632,022
2025	2025	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	1	8/28/2025	NEW	-$1
														Subtotal = $1,632,021

Grand Total All Awards = $4,901,863

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Southern California Superfund Research and Training Program for PFAS Assessment, Remediation, and Prevention (ShARP)

Award Number: P42ES036506

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/24/2025

PERIOD OF PERFORMANCE END DATE: 01/31/2030

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer