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Metals and Metal Mixtures: Cognitive Aging, Remediation and Exposure Sources (MEMCARE)

Award Number: P42ES030990
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/21/2020
PERIOD OF PERFORMANCE END DATE: 05/09/2025

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Metals and Metal Mixtures: Cognitive Aging, Remediation and Exposure Sources (MEMCARE) - SUMMARY/ ABSTRACT Health concerns of aging—especially cognitive decline and memory loss in older age—have huge public health implications as the United States and world populations are shifting in distribution toward older ages. While a variety of toxicants contribute to cognitive aging, we are focused on heavy metals (Pb, As, Mn, Cd, Cr, and Se) and metal mixtures because, despite years of regulation, clean-up, and remediation efforts, metal contamination in many Superfund sites persists and continues to threaten public health. To our knowledge, there is no current Superfund Research Center (SRC) that specifically addresses the health effects, risk, and remediation of metal contaminants in relation to their effects on cognitive health in older age. To fill this critical gap and to address the pressing public health problems posed by environmental metal contaminants on cognitive aging, we propose a new SRC entitled Metals and Metal Mixtures: Cognitive Aging, Remediation and Exposure Sources (MEMCARE). The overall goal of MEMCARE-SRC is to understand and mitigate effects of exposure to metals and metal mixtures on late-life cognitive health. To achieve this goal, we have designed a highly integrated, solution-based program of 4 Research Projects and 4 Cores. Project 1 uses an innovative approach to assess early-life exposures and late-life cognitive function in a unique population of adults now in their 60s and 70s who donated baby teeth as children. Project 2 investigates basic biological mechanisms underlying effects of early-life exposures using both in vitro and in vivo approaches. Project 3 examines the role of surface and groundwater treatment systems in spatial and temporal patterns of metals in water across the US, including Superfund sites. Project 4 will develop novel nanostructured adsorbents to remove metals from water, potentially providing improved remedies for our populations in Project 1 and the Community Engagement Core (CEC). Our CEC will partner with an urban, industrially-contaminated community in Boston, MA, and a rural community directly affected by two Superfund sites in Colorado. The Data Management and Analysis Core (DMAC) will provide data management, biostatistical, and bioinformatics support and ensure resource sharing and reproducible science for all Projects and Cores. The Administrative Core will provide oversight and communicate our science to stakeholders. The Research Experience and Training Coordination Core (RETCC) will embed with all aspects of our Center to provide doctoral and postdoctoral trainees with relevant experiences in all aspects of work in the SRC.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	5	5/9/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $1,595,150 )
2024	2024	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	5	1/26/2024	NON-COMPETING CONTINUATION	$1,595,150
2024	2024	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	5	9/19/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,595,150

Issue Date FY: 2023 ( Subtotal = $1,595,150 )
2023	2023	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	4	1/24/2023	NON-COMPETING CONTINUATION	$1,595,150
2023	2022	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	3	3/9/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2022	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	3	11/3/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,595,150

Issue Date FY: 2022 ( Subtotal = $1,611,100 )
2022	2022	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	3	8/9/2022	SUPPLEMENT FOR EXPANSION	$15,950
2022	2022	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	3	2/1/2022	NON-COMPETING CONTINUATION	$1,595,150
2022	2021	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	2	10/16/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,611,100

Issue Date FY: 2021 ( Subtotal = $1,595,150 )
2021	2021	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	2	1/23/2021	NON-COMPETING CONTINUATION	$1,595,150
2021	2021	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	2	1/26/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,595,150

Issue Date FY: 2020 ( Subtotal = $1,943,437 )
2020	2020	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	1	2/21/2020	NEW	$1,804,530
2020	2020	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	1	8/21/2020	SUPPLEMENT FOR EXPANSION	$138,907
2020	2020	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	1	8/21/2020	NEW	$0
														Subtotal = $1,943,437

Grand Total All Awards = $8,339,987

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Metals and Metal Mixtures: Cognitive Aging, Remediation and Exposure Sources (MEMCARE)

Award Number: P42ES030990

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/21/2020

PERIOD OF PERFORMANCE END DATE: 05/09/2025

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