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POLYCYCLIC AROMATIC HYDROCARBONS: ULTRASENSITIVE DETECTION,EARLY LIFE EXPOSURES-CLINICAL OUTCOMES (PRETERM BIRTHS, CHRONICLUNG DISEASE, AND NEUROCOGNITIVE DEFICITS), PREVENTION ANDREMEDIATION

Award Number: P42ES027725
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/28/2020
PERIOD OF PERFORMANCE END DATE: 01/31/2030

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POLYCYCLIC AROMATIC HYDROCARBONS: ULTRASENSITIVE DETECTION,EARLY LIFE EXPOSURES-CLINICAL OUTCOMES (PRETERM BIRTHS, CHRONICLUNG DISEASE, AND NEUROCOGNITIVE DEFICITS), PREVENTION ANDREMEDIATION - Project Summary The preterm birth (PTB) rate in Harris County, which includes Houston, TX (the 4th largest city in the US), is an alarming 12.1 % (national average in US is 9.6%). The over-arching hypothesis of the BCM-Rice SRP is that maternal exposure to polycyclic aromatic hydrocarbons (PAHs) emanating from superfund sites, as well as other environmental chemicals, increases the risk of PTBs and augments major neonatal morbidities such as BPD. The Specific Aims of the overall center are:. The overall goal of project 1 is to develop new and innovative approaches [Surface-Enhanced Raman and Infrared Absorption Spectroscopies (SERS and SEIRA)], combined with Machine Learning (ML) that enable the rapid, streamlined analysis of soil, water, and air samples for the presence of PAHs. 2. To test the hypothesis that exposures to PAHs at Superfund sites are major PTB risk factors, and that placental epigenome alterations contribute to PTB (biomedical project 2).. Furthermore, we will test the hypothesis that the aryl hydrocarbon receptor (AHR) and cytochrome P450 (CYP)1A/1B1 enzymes play a key role in PAH-mediated neonatal lung injury in mice (project 3). 3 To test the hypothesis that pyrolytic treatment of contaminated soils under carefully selected conditions will reliably achieve regulatory compliance and eliminate toxicity while recovering soil fertility to facilitate ecosystem restoration (project 4). 4. To develop innovative strategies to prevent and reduce the public health burden associated with PAHs and other hazardous chemicals present in Superfund sites [Community Engagement Core (CEC) (Core B)], and develop partnerships with primary stakeholders (i.e. EPA, ATSDR, TCEQ), communicate with NIEHS, and foster collaborations within the SRP, with sister SRP centers, and develop technology transfer [Administrative Core (AC) (Core A)]. 5. To train students and postdoctoral fellows in a cross-disciplinary manner, so that the next generation scientists, engineers, and physicians will make fundamental contributions to Environmental Health [Research Experience and Training Coordination Core (RETCC) (Core C)]. 6. To seek support of Research Support Cores that will be a central resource for multi-omics and chemical studies (Projects 1-4), and to support the management and integration of assets across all the projects and cores of the center via the Data Management and Analysis core (DMAC/Core F). Thus, this SRP uses a systems approach that integrates environmental science research, biomedical research projects, and cores to determine the mechanisms by which PAHs contribute to PTBs. and understand the factors could be targets for interventions to prevent and reduce the health burden associated with PAHs present in Superfund sites.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $2,834,801 )
2025	2025	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	6	7/22/2025	COMPETING CONTINUATION	$2,834,801
2025	2024	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	5	7/16/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,834,801

Issue Date FY: 2024 ( Subtotal = $1,724,714 )
2024	2024	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	5	9/13/2024	NON-COMPETING CONTINUATION	$28,371
2024	2024	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	5	1/26/2024	NON-COMPETING CONTINUATION	$1,696,343
2024	2024	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	5	9/16/2024	NON-COMPETING CONTINUATION	$0
2024	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	4	12/18/2023	NON-COMPETING CONTINUATION	$0
2024	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	4	11/29/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,724,714

Issue Date FY: 2023 ( Subtotal = $1,750,956 )
2023	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	4	3/31/2023	NON-COMPETING CONTINUATION	$0
2023	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	4	1/24/2023	NON-COMPETING CONTINUATION	$1,750,956
														Subtotal = $1,750,956

Issue Date FY: 2022 ( Subtotal = $1,717,009 )
2022	2022	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	3	2/1/2022	NON-COMPETING CONTINUATION	$1,750,957
2022	2021	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	2	3/2/2022	SUPPLEMENT FOR EXPANSION	-$33,948
														Subtotal = $1,717,009

Issue Date FY: 2021 ( Subtotal = $1,800,972 )
2021	2021	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	2	7/23/2021	SUPPLEMENT FOR EXPANSION	$33,949
2021	2021	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	2	7/22/2021	SUPPLEMENT FOR EXPANSION	$16,050
2021	2021	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	2	1/28/2021	NON-COMPETING CONTINUATION	$1,750,973
														Subtotal = $1,800,972

Issue Date FY: 2020 ( Subtotal = $1,960,353 )
2020	2020	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	1	2/28/2020	NEW	$1,960,353
2020	2020	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	1	9/28/2020	NEW	$0
														Subtotal = $1,960,353

Grand Total All Awards = $11,788,805

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POLYCYCLIC AROMATIC HYDROCARBONS: ULTRASENSITIVE DETECTION,EARLY LIFE EXPOSURES-CLINICAL OUTCOMES (PRETERM BIRTHS, CHRONICLUNG DISEASE, AND NEUROCOGNITIVE DEFICITS), PREVENTION ANDREMEDIATION

Award Number: P42ES027725

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/28/2020

PERIOD OF PERFORMANCE END DATE: 01/31/2030

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