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Comprehensive tools and models for addressing exposure to mixtures during environmental emergency-related contamination events

Award Number: P42ES027704
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

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Comprehensive tools and models for addressing exposure to mixtures during environmental emergency-related contamination events Overall Program Description Climate change and shifts in domestic economic activity markedly increase risks from catastrophic chemical contamination events resulting from weather-related or anthropogenic emergencies. The complexities of hazardous chemical exposures, potential adverse health impacts, and the need to rapidly and comprehensively evaluate the potential hazards of exposures to complex mixtures call for novel approaches in the Superfund Research Program. This Center brings together a team of scientists from biomedical, geosciences, data science and engineering disciplines to design comprehensive solutions for complex exposure- and hazard-related challenges. Our overall theme is to characterize and manage both existing and environmental emergency-created hazardous waste sites through the development of the tools that can be used by first responders, the impacted communities, and the government bodies involved in site management and cleanup. Our case study is a hurricane or flooding event that impacts Galveston Bay/Houston Ship Channel area and leads to exposure to contaminated sediments. Project 1 will study fate and transport of complex environmental contaminants in sediments and incorporate this information into environmental models. Project 2 will develop novel low-cost broad-acting sorption materials suitable for mitigation of acute exposures to complex contaminant mixtures. Projects 3 and 4 will take advantage of the discoveries in cell imaging and stem cell biology to establish predictive in vitro methods for quantitative evaluation of the complex mixture- perturbed adverse outcome pathways and intra- and inter-individual variability in toxicity. An Exposure Science Core will be developing and applying novel sensitive analytical methods for targeted and un-targeted analysis of a broad array of contaminants in environmental and biological samples. A Data Science Core will develop computational and statistical tools for analysis and integration of “big data” in environmental health. A Decision Science Core will develop an integrated toxicokinetic, human health, and economic models to support environmental health decisions. The Center will engage with community organizations and public health practitioners in Texas to address health concerns of the populations that may be impacted by environmental emergency-related contamination events. We will train students and postdoctoral fellows in inter-disciplinary approaches across our scientific areas, decision making and emergency response. The research translation to local, state, national and international stakeholders will be conducted through technology transfer and comprehensive outreach for the solutions developed by the Center. Finally, the management of this program will be conducted in close partnership with the administration at Texas A&M University and Health Science Center, the NIEHS-funded Center for Translational Environmental Health Research, and overseen by the advisors representing academia, federal and state agencies, industry and a non-governmental organization.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $1,815,610 )
2023	2023	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	7	6/23/2023	NON-COMPETING CONTINUATION	$1,815,610
2023	2022	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	6	2/23/2023	COMPETING CONTINUATION	$229,412
2023	2022	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	6	3/14/2023	COMPETING CONTINUATION	$0
2023	2021	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	5	2/23/2023	SUPPLEMENT FOR EXPANSION	-$1,637
2023	2021	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	5	2/23/2023	NON-COMPETING CONTINUATION	-$227,774
														Subtotal = $1,815,610

Issue Date FY: 2022 ( Subtotal = $1,852,059 )
2022	2022	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	6	9/20/2022	COMPETING CONTINUATION	$1,852,059
2022	2021	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	5	5/3/2022	NON-COMPETING CONTINUATION	$0
2022	2021	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	5	9/19/2022	NON-COMPETING CONTINUATION	$0
2022	2021	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	5	9/19/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $1,852,059

Issue Date FY: 2021 ( Subtotal = $2,122,516 )
2021	2021	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	5	3/16/2021	NON-COMPETING CONTINUATION	$2,107,366
2021	2021	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	5	7/16/2021	SUPPLEMENT FOR EXPANSION	$15,150
														Subtotal = $2,122,516

Issue Date FY: 2020 ( Subtotal = $1,962,235 )
2020	2020	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	4	4/3/2020	NON-COMPETING CONTINUATION	$1,887,263
2020	2020	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	005	4	6/3/2020	SUPPLEMENT FOR EXPANSION	$24,991
2020	2020	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	4	5/4/2020	SUPPLEMENT FOR EXPANSION	$49,981
2020	2020	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	4	4/30/2020	NON-COMPETING CONTINUATION	$0
2020	2019	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	3	12/23/2019	NON-COMPETING CONTINUATION	$0
2020	2019	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	3	11/27/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,962,235

Issue Date FY: 2019 ( Subtotal = $2,443,560 )
2019	2019	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	005	3	9/19/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2019	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	2	12/18/2018	SUPPLEMENT FOR EXPANSION	$206,810
2019	2019	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	3	9/13/2019	SUPPLEMENT FOR EXPANSION	$335,647
2019	2019	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	3	3/29/2019	NON-COMPETING CONTINUATION	$1,901,103
2019	2018	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	2	11/12/2018	NON-COMPETING CONTINUATION	$0
2019	2018	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	2	10/25/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,443,560

Issue Date FY: 2018 ( Subtotal = $1,915,191 )
2018	2018	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	2	5/22/2018	SUPPLEMENT FOR EXPANSION	$7,860
2018	2018	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	2	3/29/2018	NON-COMPETING CONTINUATION	$1,907,331
														Subtotal = $1,915,191

Issue Date FY: 2017 ( Subtotal = $1,934,028 )
2017	2017	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	1	8/31/2017	NEW	$1,934,028
														Subtotal = $1,934,028

Grand Total All Awards = $14,045,199

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Comprehensive tools and models for addressing exposure to mixtures during environmental emergency-related contamination events

Award Number: P42ES027704

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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