Thursday, November 21, 2024 11/21/2024

Comprehensive tools and models for addressing exposure to mixtures during environmental emergency-related contamination events

Award Number: P42ES027704
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Comprehensive tools and models for addressing exposure to mixtures during environmental emergency-related contamination events Overall Program Description Climate change-associated disasters coupled with economic activity and the enhanced vulnerability of already disadvantaged communities markedly increase risks from catastrophic chemical contamination events resulting from weather-related or anthropogenic emergencies. The complexities of chemical exposures and their potential adverse health impacts, the need to rapidly and comprehensively evaluate the potential hazards of exposures to complex mixtures, and the necessity of protecting vulnerable populations and life-stages call for novel approaches in the Superfund Research Program. This Center consists of a team of well-established scientists from biomedical, geosciences, data science, and engineering disciplines who share a common goal: to develop, apply, and translate a comprehensive set of tools and models that will aid first responders, impacted communities, and government agencies in characterizing and mitigating the human health consequences of exposure to hazardous mixtures. These will be applicable for both existing contaminated waste sites and disaster-related contamination events. Project 1 will develop novel analytical and computational strategies for exposure assessment of complex mixtures. Project 2 will develop novel tools to rapidly characterize pediatric respiratory health risks from exposure to hazardous volatile organic compounds after environmental disasters. Project 3 will develop and use feto-maternal interface tissue chip models for rapid assessment of preterm birth risks of hazardous substances. Project 4 will continue development of predictive in vitro methods for quantitative evaluation of the complex mixtures and intra- and inter-individual variability in toxicity. Project 5 is responsive to the Superfund remediation mandate by using experimental and computational engineering to develop optimized multi-component sorbents for toxic mixtures. A Disaster Research Response (DR2) Core will be a centralized resource for environmental sampling and assessment before, during, and after disasters. A Data Management and Analysis Core will develop computational and statistical tools for analysis and integration of “big data” in environmental health. A Risk and Geospatial Science Core will provide the Center with data and services for characterizing human health risks and the geographic distribution of hazardous substances during disasters. The Center will engage with community organizations and public health practitioners in Texas to address health concerns of the populations that may be impacted by environmental emergency-related contamination events. We will continue training students and postdoctoral fellows in inter-disciplinary approaches across our scientific areas, decision making and emergency response. The research translation to local, state, national and international stakeholders involves both technology transfer and regular outreach. Finally, the management of this program includes close partnerships with the Texas A&M University administration and the NIEHS-funded Center for Translational Environmental Health Research, and is overseen by the advisors representing academia, federal and state agencies, industry and a non-governmental organization.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $1,787,945 )
2024	2024	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	8	6/27/2024	NON-COMPETING CONTINUATION	$1,787,945
2024	2023	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	7	5/15/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,787,945

Issue Date FY: 2023 ( Subtotal = $1,815,610 )
2023	2023	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	7	6/23/2023	NON-COMPETING CONTINUATION	$1,815,610
2023	2022	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	6	2/23/2023	COMPETING CONTINUATION	$229,412
2023	2022	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	6	3/14/2023	COMPETING CONTINUATION	$0
2023	2021	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	5	2/23/2023	SUPPLEMENT FOR EXPANSION	-$1,637
2023	2021	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	5	2/23/2023	NON-COMPETING CONTINUATION	-$227,774
														Subtotal = $1,815,610

Issue Date FY: 2022 ( Subtotal = $1,852,059 )
2022	2022	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	6	9/20/2022	COMPETING CONTINUATION	$1,852,059
2022	2021	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	5	5/3/2022	NON-COMPETING CONTINUATION	$0
2022	2021	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	5	9/19/2022	NON-COMPETING CONTINUATION	$0
2022	2021	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	5	9/19/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $1,852,059

Issue Date FY: 2021 ( Subtotal = $2,122,516 )
2021	2021	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	5	7/16/2021	SUPPLEMENT FOR EXPANSION	$15,150
2021	2021	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	5	3/16/2021	NON-COMPETING CONTINUATION	$2,107,366
														Subtotal = $2,122,516

Issue Date FY: 2020 ( Subtotal = $1,962,235 )
2020	2020	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	4	4/3/2020	NON-COMPETING CONTINUATION	$1,887,263
2020	2020	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	005	4	6/3/2020	SUPPLEMENT FOR EXPANSION	$24,991
2020	2020	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	4	5/4/2020	SUPPLEMENT FOR EXPANSION	$49,981
2020	2020	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	4	4/30/2020	NON-COMPETING CONTINUATION	$0
2020	2019	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	3	12/23/2019	NON-COMPETING CONTINUATION	$0
2020	2019	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	3	11/27/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,962,235

Issue Date FY: 2019 ( Subtotal = $2,443,560 )
2019	2019	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	005	3	9/19/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2019	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	2	12/18/2018	SUPPLEMENT FOR EXPANSION	$206,810
2019	2019	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	3	9/13/2019	SUPPLEMENT FOR EXPANSION	$335,647
2019	2019	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	3	3/29/2019	NON-COMPETING CONTINUATION	$1,901,103
2019	2018	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	2	11/12/2018	NON-COMPETING CONTINUATION	$0
2019	2018	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	2	10/25/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,443,560

Issue Date FY: 2018 ( Subtotal = $1,915,191 )
2018	2018	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	2	5/22/2018	SUPPLEMENT FOR EXPANSION	$7,860
2018	2018	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	2	3/29/2018	NON-COMPETING CONTINUATION	$1,907,331
														Subtotal = $1,915,191

Issue Date FY: 2017 ( Subtotal = $1,934,028 )
2017	2017	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	1	8/31/2017	NEW	$1,934,028
														Subtotal = $1,934,028

Grand Total All Awards = $15,833,144

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Comprehensive tools and models for addressing exposure to mixtures during environmental emergency-related contamination events

Award Number: P42ES027704

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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