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UNM Metals Exposure and Toxicity Assessment on tribal Lands in the Southwest (METALS) Superfund Research Program

Award Number: P42ES025589
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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OVERALL Summary METALS The UNM Metal Exposure and Toxicity Assessment on tribal Lands of the Southwest SRP Center (METALS) focuses on >500 abandoned uranium mines (AUMs) on Navajo Nation, and the Jackpile Mine on Laguna Pueblo, a legacy of the Cold War now being assessed under CERCLA. They represent >4500 AUMs in the 15 Western US that are home to >1/2 of our Indigenous population. During the inaugural phase of METALS, our team worked in close partnership with our Indigenous partners to determine that since mining began in the 1940s, weathering of metal mixtures in the millions of tons of waste has produced nanoparticles of varying mineralogy. While these nanoparticles have implications for both mobility and toxicity of the waste, they are not considered in prioritization or clean-up due to significant data gaps. Our health studies have shown that exposures to these metal mixtures increase the prevalence of hypertension, multiple chronic diseases, and immune dysfunction, and autoantibody production. While ~25% of the population shows no evidence of exposures, biomonitoring confirms an equivalent %age show exposure to clusters of up to 12 metals at significantly higher concentrations than the rest of the US population. Our community-partnered approach and strong team integration inclusive of community partners has allowed our design of clinical interventions that are scientifically sound and respectful of culture, in which we have high rates of participation and compliance. Phase 2 of METALS will build on our strong community partnerships to drive our research by their needs, and use single atom, state of the science, transmission electron microscopy to both answer community questions on agricultural safety as impacted by particulate redistribution, and understand the processes of resuspension, environmental mobility, and plant uptake at a mechanistic scale to inform risk reduction. Our confirmation of multiple routes of exposures, and evidence of metals-induced inflammation and oxidative stress lead us to examine contributions of ingestion and inhalation within community exposures. These studies will explore the potential for high-dose exposures to immune regulatory cells in lung and gut to alter systemic immune function, informing design of more targeted intervention. Our recognition of the role of plant/fungi symbiosis in transformation of environmental metal mixtures has led to our collaboration with the national Sevilleta Long Term Ecological Research program in New Mexico in development and testing of fungal bioreactors based in the balance of native fungal communities and their interactions with geochemical variables as a remediation strategy. These remediation approaches provide a novel strategy to overcome the ineffectiveness of bacterial bioreactors in our oxic environment and produce sustainable, cost-effective solutions to protect key resources of cultural importance. Our team will build on our strong partnerships to build common dialogue with communities, researchers, clinicians, tribal and federal policy makers, informed by our solution-oriented team science to inform risk reduction at community, clinical and policy levels.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $1,774,184 )
2024	2024	UNIVERSITY OF NEW MEXICO	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	8	6/25/2024	NON-COMPETING CONTINUATION	$1,774,184
														Subtotal = $1,774,184

Issue Date FY: 2023 ( Subtotal = $1,930,318 )
2023	2023	UNIVERSITY OF NEW MEXICO	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	005	7	9/29/2023	NON-COMPETING CONTINUATION	$0
2023	2023	UNIVERSITY OF NEW MEXICO	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	7	7/18/2023	NON-COMPETING CONTINUATION	$1,930,318
2023	2022	UNIVERSITY OF NEW MEXICO	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	6	12/12/2022	COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF NEW MEXICO	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	6	3/13/2023	COMPETING CONTINUATION	$292,238
2023	2021	UNIVERSITY OF NEW MEXICO	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	5	3/13/2023	NON-COMPETING CONTINUATION	-$282,577
2023	2021	UNIVERSITY OF NEW MEXICO	1 UNIVERSITY OF NEW MEXICO	ALBUQUERQUE	NM	87131	BERNALILLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	5	3/13/2023	SUPPLEMENT FOR EXPANSION	-$9,661
														Subtotal = $1,930,318

Issue Date FY: 2022 ( Subtotal = $1,839,044 )
2022	2022	UNIVERSITY OF NEW MEXICO	2500 MARBLE DR NE	ALBUQUERQUE	NM	87131	BERNALILLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	6	9/20/2022	COMPETING CONTINUATION	$1,839,044
2022	2021	UNIVERSITY OF NEW MEXICO	2500 MARBLE DR NE	ALBUQUERQUE	NM	87131	BERNALILLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	5	9/19/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2021	UNIVERSITY OF NEW MEXICO	2500 MARBLE DR NE	ALBUQUERQUE	NM	87131	BERNALILLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	5	9/19/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,839,044

Issue Date FY: 2021 ( Subtotal = $1,512,535 )
2021	2021	UNIVERSITY OF NEW MEXICO	2500 MARBLE DR NE	ALBUQUERQUE	NM	87131	BERNALILLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	5	8/31/2021	NON-COMPETING CONTINUATION	$0
2021	2021	UNIVERSITY OF NEW MEXICO	2500 MARBLE DR NE	ALBUQUERQUE	NM	87131	BERNALILLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	5	7/22/2021	SUPPLEMENT FOR EXPANSION	$50,000
2021	2021	UNIVERSITY OF NEW MEXICO	2500 MARBLE DR NE	ALBUQUERQUE	NM	87131	BERNALILLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	5	3/24/2021	NON-COMPETING CONTINUATION	$1,462,535
														Subtotal = $1,512,535

Issue Date FY: 2020 ( Subtotal = $1,271,267 )
2020	2020	UNIVERSITY OF NEW MEXICO	2500 MARBLE DR NE	ALBUQUERQUE	NM	87131	BERNALILLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	4	4/6/2020	NON-COMPETING CONTINUATION	$1,271,267
														Subtotal = $1,271,267

Issue Date FY: 2019 ( Subtotal = $1,858,885 )
2019	2019	UNIVERSITY OF NEW MEXICO	2500 MARBLE DR NE	ALBUQUERQUE	NM	87131	BERNALILLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	3	9/13/2019	SUPPLEMENT FOR EXPANSION	$568,136
2019	2019	UNIVERSITY OF NEW MEXICO	2500 MARBLE DR NE	ALBUQUERQUE	NM	87131	BERNALILLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	3	5/21/2019	SUPPLEMENT FOR EXPANSION	$10,536
2019	2019	UNIVERSITY OF NEW MEXICO	2500 MARBLE DR NE	ALBUQUERQUE	NM	87131	BERNALILLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	3	3/29/2019	NON-COMPETING CONTINUATION	$1,280,213
2019	2019	UNIVERSITY OF NEW MEXICO	2500 MARBLE DR NE	ALBUQUERQUE	NM	87131	BERNALILLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	3	9/19/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2018	UNIVERSITY OF NEW MEXICO	2500 MARBLE DR NE	ALBUQUERQUE	NM	87131	BERNALILLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	2	12/7/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,858,885

Issue Date FY: 2018 ( Subtotal = $1,287,660 )
2018	2018	UNIVERSITY OF NEW MEXICO	2500 MARBLE DR NE	ALBUQUERQUE	NM	87131	BERNALILLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	2	3/27/2018	NON-COMPETING CONTINUATION	$1,287,660
														Subtotal = $1,287,660

Issue Date FY: 2017 ( Subtotal = $1,297,378 )
2017	2017	UNIVERSITY OF NEW MEXICO	2500 MARBLE DR NE	ALBUQUERQUE	NM	87131	BERNALILLO	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	1	8/14/2017	NEW	$1,297,378
														Subtotal = $1,297,378

Grand Total All Awards = $12,771,271

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UNM Metals Exposure and Toxicity Assessment on tribal Lands in the Southwest (METALS) Superfund Research Program

Award Number: P42ES025589

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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