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Center for the Science, Technology, and Emerging Health Risks of PAHs

Award Number: P42ES016465
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/17/2009
PERIOD OF PERFORMANCE END DATE: 01/31/2030

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Center for the Science, Technology, and Emerging Health Risks of PAHs - SUMMARY – OVERALL CENTER The mission of the Oregon State University (OSU) SRP Center is to identify polycyclic aromatic hydrocarbons (PAHs) in the environment, to characterize their toxicity, and to specify the environmental concentrations below which they pose no threat to human health. The OSU SRC will study the composition of complex PAH mixtures, the changes in composition after remediation and natural attenuation, and the implications of PAH mixtures for human health. The scientific community does not fully understand the toxicity of structurally diverse, substituted PAHs, nor the toxicity of complex environmental PAH mixtures. We do not fully understand the degree to which typical environmental exposures to PAHs threaten human health, particularly in vulnerable populations. We cannot yet predict the biological effects of complex PAH mixtures. We cannot identify the sources of PAHs. Site managers, being unable to distinguish between PAHs from legacy sources (such as petrochemical plants) and PAHs from contemporary sources (such as wildfires), cannot optimize their remediation plans, nor can they evaluate their remediation efforts. Communities can apply passive sampling devices to determine whether they are being exposed to PAHs, but they do not know the sources of those PAHs and therefore cannot devise effective plans to protect themselves. The OSU SRP Center proposes to answer these scientific questions: What doses of PAHs and a-PAHs (what is that?) can cause cancer and evoke other adverse responses in humans? Do typical environmental exposures to PAHs threaten human health? By what biological mechanisms do PAHs exert adverse effects? How does the toxicity of PAHs depend on their chemical structures? Can long-term zebrafish studies evaluate the carcinogenicity of PAHs? Can we identify gene expression pathways specific to each category of PAHs? Do common genetic polymorphisms alter toxicity and subsequent risk to PAH exposure and thereby allow us to identify susceptible individuals? How does the toxicity of PAHs and PAH mixtures depend on variations in susceptibility caused by stressors? How can we identify the components in a complex PAH mixture that are causing additive, synergistic, or antagonistic toxicity? How do novel and abundant a-PAHs contribute to toxicity in mixtures? Can current remediation techniques reduce human health hazards? How can we develop novel, safe, sustainable systems that treat PAH mixtures while minimizing the formation of hazardous PAH breakdown products? How do PAHs move into, through, and away from Superfund sites? How can we identify the sources of PAHs in ways that not only enable communities to minimize their exposure but also enable remediators to optimize their remediation plans and evaluate their remediation efforts?


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $2,736,987 )
2025	2025	OREGON STATE UNIVERSITY	1500 SW JEFFERSON AVE	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	16	6/23/2025	COMPETING CONTINUATION	$2,736,987
2025	2024	OREGON STATE UNIVERSITY	1500 SW JEFFERSON AVE	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	15	6/17/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,736,987

Issue Date FY: 2024 ( Subtotal = $2,501,996 )
2024	2024	OREGON STATE UNIVERSITY	1500 SW JEFFERSON AVE	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	15	1/31/2024	SUPPLEMENT FOR EXPANSION	$7,768
2024	2024	OREGON STATE UNIVERSITY	1500 SW JEFFERSON AVE	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	15	1/30/2024	NON-COMPETING CONTINUATION	$2,494,228
														Subtotal = $2,501,996

Issue Date FY: 2023 ( Subtotal = $2,536,460 )
2023	2023	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	14	3/27/2023	SUPPLEMENT FOR EXPANSION	$42,232
2023	2023	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	14	1/30/2023	NON-COMPETING CONTINUATION	$2,494,228
2023	2022	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	13	11/10/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,536,460

Issue Date FY: 2022 ( Subtotal = $2,547,099 )
2022	2022	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	13	2/17/2022	SUPPLEMENT FOR EXPANSION	$50,000
2022	2022	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	13	4/13/2022	NON-COMPETING CONTINUATION	$0
2022	2022	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	13	7/1/2022	NON-COMPETING CONTINUATION	$0
2022	2022	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	13	2/15/2022	NON-COMPETING CONTINUATION	$2,497,099
2022	2021	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	12	10/15/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,547,099

Issue Date FY: 2021 ( Subtotal = $2,526,139 )
2021	2021	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	12	7/23/2021	SUPPLEMENT FOR EXPANSION	$14,850
2021	2021	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	12	2/3/2021	NON-COMPETING CONTINUATION	$2,497,441
2021	2021	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	12	7/22/2021	SUPPLEMENT FOR EXPANSION	$13,848
2021	2020	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	11	1/12/2021	COMPETING CONTINUATION	$0
2021	2020	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	11	11/6/2020	COMPETING CONTINUATION	$0
														Subtotal = $2,526,139

Issue Date FY: 2020 ( Subtotal = $2,724,824 )
2020	2020	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	11	4/3/2020	COMPETING CONTINUATION	$0
2020	2020	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	11	6/4/2020	SUPPLEMENT FOR EXPANSION	$7,344
2020	2020	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	11	3/30/2020	COMPETING CONTINUATION	$2,717,480
2020	2017	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	10	9/17/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,724,824

Issue Date FY: 2019 ( Subtotal = $397,097 )
2019	2019	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	10	9/11/2019	SUPPLEMENT FOR EXPANSION	$397,097
2019	2019	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	10	9/18/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2018	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	10	3/15/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2017	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	10	3/15/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $397,097

Issue Date FY: 2018 ( Subtotal = $3,067,853 )
2018	2018	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	10	7/12/2018	SUPPLEMENT FOR EXPANSION	$3,067,853
														Subtotal = $3,067,853

Issue Date FY: 2017 ( Subtotal = $2,998,492 )
2017	2017	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	10	6/23/2017	NON-COMPETING CONTINUATION	$244,776
2017	2017	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	10	3/28/2017	NON-COMPETING CONTINUATION	$2,753,716
														Subtotal = $2,998,492

Issue Date FY: 2016 ( Subtotal = $3,025,643 )
2016	2016	OREGON STATE UNIVERSITY	OFFICE OF POST AWARD ADMINISTRATION	CORVALLIS	OR	97339	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	9	3/24/2016	NON-COMPETING CONTINUATION	$2,937,296
2016	2016	OREGON STATE UNIVERSITY	OFFICE OF POST AWARD ADMINISTRATION	CORVALLIS	OR	97339	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	9	9/26/2016	SUPPLEMENT FOR EXPANSION	$88,347
														Subtotal = $3,025,643

Issue Date FY: 2015 ( Subtotal = $3,079,713 )
2015	2015	OREGON STATE UNIVERSITY	OFFICE OF POST AWARD ADMINISTRATION	CORVALLIS	OR	97339	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	7	4/1/2015	NON-COMPETING CONTINUATION	$3,068,913
2015	2015	OREGON STATE UNIVERSITY	OFFICE OF POST AWARD ADMINISTRATION	CORVALLIS	OR	97339	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	8	5/20/2015	SUPPLEMENT FOR EXPANSION	$10,800
2015	2015	OREGON STATE UNIVERSITY	OFFICE OF POST AWARD ADMINISTRATION	CORVALLIS	OR	97339	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	006	8	6/17/2015	SUPPLEMENT FOR EXPANSION	-$10,800
2015	2015	OREGON STATE UNIVERSITY	OFFICE OF POST AWARD ADMINISTRATION	CORVALLIS	OR	97339	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	005	8	6/17/2015	SUPPLEMENT FOR EXPANSION	$10,800
2015	2015	OREGON STATE UNIVERSITY	OFFICE OF POST AWARD ADMINISTRATION	CORVALLIS	OR	97339	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	7	4/24/2015	NON-COMPETING CONTINUATION	-$3,068,913
2015	2015	OREGON STATE UNIVERSITY	OFFICE OF POST AWARD ADMINISTRATION	CORVALLIS	OR	97339	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	7	5/11/2015	NON-COMPETING CONTINUATION	$0
2015	2015	OREGON STATE UNIVERSITY	OFFICE OF POST AWARD ADMINISTRATION	CORVALLIS	OR	97339	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	8	5/12/2015	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$3,068,913
														Subtotal = $3,079,713

Issue Date FY: 2014 ( Subtotal = $2,989,969 ) (Continued on the next page)
2014	2014	OREGON STATE UNIVERSITY	P.O. BOX 1086	CORVALLIS	OR	97339	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	6	4/11/2014	NON-COMPETING CONTINUATION	$2,979,169
Grand Total All Awards = $46,398,122

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Center for the Science, Technology, and Emerging Health Risks of PAHs

Award Number: P42ES016465

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/17/2009

PERIOD OF PERFORMANCE END DATE: 01/31/2030

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