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PAHs: New Technologies and Emerging Health Risks

Award Number: P42ES016465
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/17/2009
PERIOD OF PERFORMANCE END DATE: 06/23/2025

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PAHs: New Technologies and Emerging Health Risks - SUMMARY – OVERALL CENTER The Oregon State University Superfund Research Program (SRP), in partnership with Pacific Northwest National Laboratories and other stakeholders and collaborators, seeks to develop new technologies to identify the polycyclic aromatic hydrocarbon (PAHs) mixtures found at many of the nation's Superfund sites before and after remediation. We will identify novel hazard and toxicity mechanisms for PAHs and real-world PAH mixtures. The SRP will support three biomedical research projects and two environmental science and engineering projects. We aligned these research projects with the four SRP mandates to address pressing challenges at Superfund sites. The Administrative, Community Engagement, Chemical Mixtures, Research Experience and Training, and Data Management and Analysis cores support the research projects. This proposal builds on our successes during the previous grant period. Over the next five years, we will pursue innovative, high-impact research goals. For example, we propose to (1) develop the first generalizable technology to measure the movement of PAHs to and from Superfund sites, (2) measure external exposures to PAHs for individuals near Superfund sites and determine how their exposures vary as a function of location, (3) predict the secondary transformation products of PAHs that will form during biotic and abiotic remediation at Superfund sites, (4) predict the toxicity of complex PAH mixtures using zebrafish, (5) link PAH exposure to health outcomes with the aid of a powerful human in vitro respiratory model, and (6) elucidate metabolic and physicochemical control of PAH susceptibility in toxicity systems. The cores will (1) direct the activities of the SRP and disseminate our findings to stakeholders (Administrative), (2) work with communities impacted by PAH exposure to address concerns and reduce risk (Community Engagement); (3) provide intensive multi-disciplinary training for the next generation of Environmental Health Scientists (RETCC), (4) provide data management and analysis support (DMAC), and (5) apply state-of- the-art chemistry instrumentation and approaches to measure PAHs and PAH mixtures found in environmental and biological matrices. By accomplishing these goals, we will advance the frontiers of science and also improve the quality of life for impacted communities.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $2,736,987 )
2025	2025	OREGON STATE UNIVERSITY	1500 SW JEFFERSON AVE	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	16	6/23/2025	COMPETING CONTINUATION	$2,736,987
2025	2024	OREGON STATE UNIVERSITY	1500 SW JEFFERSON AVE	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	15	7/17/2025	NON-COMPETING CONTINUATION	$0
2025	2024	OREGON STATE UNIVERSITY	1500 SW JEFFERSON AVE	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	15	6/17/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,736,987

Issue Date FY: 2024 ( Subtotal = $2,501,996 )
2024	2024	OREGON STATE UNIVERSITY	1500 SW JEFFERSON AVE	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	15	1/31/2024	SUPPLEMENT FOR EXPANSION	$7,768
2024	2024	OREGON STATE UNIVERSITY	1500 SW JEFFERSON AVE	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	15	1/30/2024	NON-COMPETING CONTINUATION	$2,494,228
														Subtotal = $2,501,996

Issue Date FY: 2023 ( Subtotal = $2,536,460 )
2023	2023	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	14	3/27/2023	SUPPLEMENT FOR EXPANSION	$42,232
2023	2023	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	14	1/30/2023	NON-COMPETING CONTINUATION	$2,494,228
2023	2022	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	13	11/10/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,536,460

Issue Date FY: 2022 ( Subtotal = $2,547,099 )
2022	2022	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	13	2/17/2022	SUPPLEMENT FOR EXPANSION	$50,000
2022	2022	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	13	4/13/2022	NON-COMPETING CONTINUATION	$0
2022	2022	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	13	2/15/2022	NON-COMPETING CONTINUATION	$2,497,099
2022	2022	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	13	7/1/2022	NON-COMPETING CONTINUATION	$0
2022	2021	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	12	10/15/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,547,099

Issue Date FY: 2021 ( Subtotal = $2,526,139 )
2021	2021	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	12	7/23/2021	SUPPLEMENT FOR EXPANSION	$14,850
2021	2021	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	12	2/3/2021	NON-COMPETING CONTINUATION	$2,497,441
2021	2021	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	12	7/22/2021	SUPPLEMENT FOR EXPANSION	$13,848
2021	2020	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	11	1/12/2021	COMPETING CONTINUATION	$0
2021	2020	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	11	11/6/2020	COMPETING CONTINUATION	$0
														Subtotal = $2,526,139

Issue Date FY: 2020 ( Subtotal = $2,724,824 )
2020	2020	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	11	4/3/2020	COMPETING CONTINUATION	$0
2020	2020	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	11	6/4/2020	SUPPLEMENT FOR EXPANSION	$7,344
2020	2020	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	11	3/30/2020	COMPETING CONTINUATION	$2,717,480
2020	2017	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	10	9/17/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,724,824

Issue Date FY: 2019 ( Subtotal = $397,097 )
2019	2019	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	10	9/11/2019	SUPPLEMENT FOR EXPANSION	$397,097
2019	2019	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	10	9/18/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2018	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	10	3/15/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2017	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	10	3/15/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $397,097

Issue Date FY: 2018 ( Subtotal = $3,067,853 )
2018	2018	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	10	7/12/2018	SUPPLEMENT FOR EXPANSION	$3,067,853
														Subtotal = $3,067,853

Issue Date FY: 2017 ( Subtotal = $2,998,492 )
2017	2017	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	10	6/23/2017	NON-COMPETING CONTINUATION	$244,776
2017	2017	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	10	3/28/2017	NON-COMPETING CONTINUATION	$2,753,716
														Subtotal = $2,998,492

Issue Date FY: 2016 ( Subtotal = $3,025,643 )
2016	2016	OREGON STATE UNIVERSITY	OFFICE OF POST AWARD ADMINISTRATION	CORVALLIS	OR	97339	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	9	3/24/2016	NON-COMPETING CONTINUATION	$2,937,296
2016	2016	OREGON STATE UNIVERSITY	OFFICE OF POST AWARD ADMINISTRATION	CORVALLIS	OR	97339	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	9	9/26/2016	SUPPLEMENT FOR EXPANSION	$88,347
														Subtotal = $3,025,643

Issue Date FY: 2015 ( Subtotal = $3,079,713 )
2015	2015	OREGON STATE UNIVERSITY	OFFICE OF POST AWARD ADMINISTRATION	CORVALLIS	OR	97339	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	7	4/1/2015	NON-COMPETING CONTINUATION	$3,068,913
2015	2015	OREGON STATE UNIVERSITY	OFFICE OF POST AWARD ADMINISTRATION	CORVALLIS	OR	97339	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	8	5/20/2015	SUPPLEMENT FOR EXPANSION	$10,800
2015	2015	OREGON STATE UNIVERSITY	OFFICE OF POST AWARD ADMINISTRATION	CORVALLIS	OR	97339	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	006	8	6/17/2015	SUPPLEMENT FOR EXPANSION	-$10,800
2015	2015	OREGON STATE UNIVERSITY	OFFICE OF POST AWARD ADMINISTRATION	CORVALLIS	OR	97339	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	005	8	6/17/2015	SUPPLEMENT FOR EXPANSION	$10,800
2015	2015	OREGON STATE UNIVERSITY	OFFICE OF POST AWARD ADMINISTRATION	CORVALLIS	OR	97339	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	7	4/24/2015	NON-COMPETING CONTINUATION	-$3,068,913
2015	2015	OREGON STATE UNIVERSITY	OFFICE OF POST AWARD ADMINISTRATION	CORVALLIS	OR	97339	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	7	5/11/2015	NON-COMPETING CONTINUATION	$0
2015	2015	OREGON STATE UNIVERSITY	OFFICE OF POST AWARD ADMINISTRATION	CORVALLIS	OR	97339	BENTON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	8	5/12/2015	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$3,068,913
														Subtotal = $3,079,713

Issue Date FY: 2014 ( Subtotal = $2,989,969 ) (Continued on the next page)
Grand Total All Awards = $46,398,122

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PAHs: New Technologies and Emerging Health Risks

Award Number: P42ES016465

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/17/2009

PERIOD OF PERFORMANCE END DATE: 06/23/2025

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