Sunday, November 24, 2024 11/24/2024

Airborne PCBs: Sources, Exposures, Toxicities, Remediation

Award Number: P42ES013661
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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SUMMARY: Iowa Superfund Research Program Overall The Iowa Superfund Research Program (ISRP) is a center of research excellence focused on polychlorinated biphenyls (PCBs). PCBs were widely produced in the mid-20th century and used in thousands of products, from common household items to construction materials, until the chemicals were banned 40 years ago. Today, people are still exposed to PCBs indoors and in communities surrounding Superfund sites. Recent ISRP research demonstrated that airborne PCBs present an especially urgent problem: Inhalation of airborne PCBs may be the most significant route for human exposure to these important toxic chemicals. The ISRP’s long- term goal is to develop recommendations to prevent and/or limit human exposure to airborne PCBs and to improve the health and well-being of the population. The ISRP renewal will focus on PCBs in air, particularly in buildings (especially schools) and those emitted from contaminated waters (including Superfund sites). We will examine the health impacts of inhaled PCBs, particularly on adolescents, with a focus on neurodevelopmental and metabolic effects. The ISRP will accomplish its long-term goal through the following integrated Specific Aims: 1) Clarify the biochemical mechanisms of toxicity of lower-chlorinated PCBs in adolescence. Two projects will address how PCBs and their metabolites are risk factors for altered neurodevelopment during adolescence and the mechanisms by which these compounds interfere with lipid metabolism. 2) Define susceptible populations, assess exposure and accumulation of these compounds (particularly in schools), and evaluate the relative importance of airborne vs. dietary exposure. Three cohorts of mothers and adolescents will help us evaluate individuals’ exposure to airborne PCBs, the specific environments that contribute to inhalation exposure, and its importance compared to exposure through diet. 3) Reduce emissions of airborne PCBs from building materials, products, and contaminated sediments. We will investigate sources of airborne PCBs in indoor environments, determine the magnitude of emissions from contaminated waters, and identify cost-effective strategies to remove or reduce emissions. This includes development of a new approach using novel materials to sequester lower chlorinated PCBs in sediments and break down PCBs through microbial processes to reduce PCB emissions from contaminated waters. 4) Train and attract new scientists to the environmental health sciences. Our training program will enhance research skills in data science, chemical analysis, community engagement, and research translation. 5) Engage the scientific community and stakeholders in bi-directional communication on ISRP research priorities, findings, and recommendations. We will communicate the ISRP’s research approaches and findings to a wide range of researchers, agencies, and community stakeholders to maximize impact and enable communities to make timely, informed decisions to reduce local PCB exposure.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $2,204,080 )
2024	2024	THE UNIVERSITY OF IOWA	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	19	9/16/2024	NON-COMPETING CONTINUATION	$150,713
2024	2024	THE UNIVERSITY OF IOWA	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	19	1/5/2024	NON-COMPETING CONTINUATION	$2,053,367
2024	2024	THE UNIVERSITY OF IOWA	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	19	7/22/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,204,080

Issue Date FY: 2023 ( Subtotal = $2,237,645 )
2023	2023	THE UNIVERSITY OF IOWA	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	18	1/24/2023	NON-COMPETING CONTINUATION	$2,237,645
2023	2023	THE UNIVERSITY OF IOWA	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	18	6/15/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,237,645

Issue Date FY: 2022 ( Subtotal = $2,253,095 )
2022	2022	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	17	4/29/2022	NON-COMPETING CONTINUATION	$0
2022	2022	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	17	2/1/2022	NON-COMPETING CONTINUATION	$2,237,645
2022	2022	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	17	8/9/2022	SUPPLEMENT FOR EXPANSION	$15,450
														Subtotal = $2,253,095

Issue Date FY: 2021 ( Subtotal = $2,298,846 )
2021	2021	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	16	7/16/2021	SUPPLEMENT FOR EXPANSION	$11,201
2021	2021	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	16	1/28/2021	NON-COMPETING CONTINUATION	$2,237,645
2021	2021	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	16	2/26/2021	SUPPLEMENT FOR EXPANSION	$50,000
														Subtotal = $2,298,846

Issue Date FY: 2020 ( Subtotal = $2,457,826 )
2020	2020	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	15	4/13/2020	COMPETING CONTINUATION	$0
2020	2020	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	15	3/31/2020	COMPETING CONTINUATION	$2,447,026
2020	2020	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	15	6/29/2020	SUPPLEMENT FOR EXPANSION	$10,800
2020	2020	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	007	15	9/19/2020	COMPETING CONTINUATION	$653,373
2020	2020	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	15	4/6/2020	COMPETING CONTINUATION	$0
2020	2019	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	005	14	9/19/2020	NON-COMPETING CONTINUATION	-$237,726
2020	2019	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	006	14	9/19/2020	SUPPLEMENT FOR EXPANSION	-$415,647
2020	2019	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	14	12/13/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,457,826

Issue Date FY: 2019 ( Subtotal = $2,726,226 )
2019	2019	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	14	9/13/2019	SUPPLEMENT FOR EXPANSION	$415,647
2019	2019	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	14	4/1/2019	NON-COMPETING CONTINUATION	$2,310,579
2019	2019	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	14	7/4/2019	NON-COMPETING CONTINUATION	$0
2019	2019	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	14	9/19/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2018	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	13	12/7/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,726,226

Issue Date FY: 2018 ( Subtotal = $2,460,602 )
2018	2018	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	13	9/10/2018	SUPPLEMENT FOR EXPANSION	$120,226
2018	2018	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	13	3/23/2018	NON-COMPETING CONTINUATION	$2,340,376
														Subtotal = $2,460,602

Issue Date FY: 2017 ( Subtotal = $2,349,805 )
2017	2017	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	12	6/23/2017	NON-COMPETING CONTINUATION	$190,067
2017	2017	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	12	5/8/2017	SUPPLEMENT FOR EXPANSION	$10,796
2017	2017	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	12	5/9/2017	SUPPLEMENT FOR EXPANSION	$10,687
2017	2017	UNIVERSITY OF IOWA, THE	105 JESSUP HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	12	3/17/2017	NON-COMPETING CONTINUATION	$2,138,255
														Subtotal = $2,349,805

Issue Date FY: 2016 ( Subtotal = $2,411,778 )
2016	2016	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	11	3/25/2016	NON-COMPETING CONTINUATION	$2,411,778
2016	2015	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	10	10/22/2015	COMPETING CONTINUATION	$0
2016	2015	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	10	1/14/2016	COMPETING CONTINUATION	$0
														Subtotal = $2,411,778

Issue Date FY: 2015 ( Subtotal = $2,489,430 ) (Continued on the next page)
2015	2015	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Hazardous Waste Worker Health and Safety Training	002	9	5/5/2015	SUPPLEMENT FOR EXPANSION	$0
2015	2015	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	007	10	9/24/2015	COMPETING CONTINUATION	$2,329,783
2015	2015	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	006	9	9/23/2015	SUPPLEMENT FOR EXPANSION	$0
2015	2015	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	9	6/17/2015	SUPPLEMENT FOR EXPANSION	$148,852
2015	2015	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Hazardous Waste Worker Health and Safety Training	001	9	5/1/2015	SUPPLEMENT FOR EXPANSION	$10,795
2015	2014	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	005	9	9/23/2015	SUPPLEMENT FOR EXPANSION	$0
2015	2014	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	9	4/17/2015	NON-COMPETING CONTINUATION	$0
Grand Total All Awards = $51,414,459

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Airborne PCBs: Sources, Exposures, Toxicities, Remediation

Award Number: P42ES013661

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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