Monday, September 25, 2023 9/25/2023

LSU Superfund Research Center - Environmentally Persistent Free Radicals

Award Number: P42ES013648
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract: Overall Nearly 53 million people (17% of the US population; 18% of children <5 yrs) live within 3 miles of a Superfund remediation site. Superfund sites contain a wide variety of pollutants, including organic chemicals, metals, carbo- naceous material and silica. Although each of these components is capable of damage to organisms, their poten- tial to combine into unique hazardous agents has been understudied. Interestingly, when these agents are pre- sent together, particularly during thermal remediation, they combine to form particulate matter (PM) with chemi- sorbed free radicals that persist in the environment and yet are biologically active. We call these pollutant-particle systems environmentally persistent free radicals (EPFRs). EPFRs are produced during thermal treatment of haz- ardous wastes and nearly 30% of all Superfund sites (excluding groundwater) are remediated by thermal treat- ment. EPFR concentrations near Superfund sites range from 1x1018-4x1019 EPFRs/g (spins/g) of PM. This sug- gests a vast number of US residents are exposed to PM containing EPFRs. LSU Superfund Research Center researchers have shown that these EPFRs 1) induce cardiac and pulmonary dysfunction in the exposed host, 2) are associated with current wheeze in children if present in household dust, and 3) are intermediates in the for- mation of new pollutants such as dioxins. Our Center now seeks to understand how EPFRs induce pulmo- nary/cardiovascular dysfunction and how to attenuate EPFR formation, facilitate EPFR decay, and limit exposure to EPFRs, with the ultimate goal of improving human health and the environment. We will determine how EPFRs are formed, stabilized, and decay and how they catalytically cycle to produce hydroxyl radicals. This will be done using a suite of advanced surface and chemical analyses. Since the airway is a major site of entry of environ- mental PM, we will demonstrate a link between EPFR exposure and poor respiratory health in children using es- tablished community-based birth cohorts. We will explore mechanisms of EPFR-induced asthma and cardiovas- cular disease using mouse models exposed by inhalation. Support cores (Administration, Data Management & Analysis, Community Engagement, Research Experience and Training Coordination, Materials, and Inhalation Toxicology) will provide essential, centralized reagents/services and technological resources allowing for precision of data and economy of effort, and foster interdisciplinary activities. To ensure success, experts in these respective fields were brought together as an External Advisory Committee to advise this Center. The chemistry and physics of EPFRs, let alone their health impacts, are poorly understood, and an interdisciplinary approach is required to address the critical research areas.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $2,147,281 )
2023	2023	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	11	1/31/2023	NON-COMPETING CONTINUATION	$2,126,450
2023	2023	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	11	5/19/2023	NON-COMPETING CONTINUATION	$0
2023	2023	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	11	2/1/2023	SUPPLEMENT FOR EXPANSION	$20,831


Issue Date FY: 2022 ( Subtotal = $2,195,323 )
2022	2022	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	10	8/9/2022	SUPPLEMENT FOR EXPANSION	$14,800
2022	2022	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	10	6/17/2022	NON-COMPETING CONTINUATION	$0
2022	2022	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	005	10	8/18/2022	SUPPLEMENT FOR EXPANSION	$12,600
2022	2022	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	10	2/17/2022	NON-COMPETING CONTINUATION	$2,120,688
2022	2022	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	10	3/25/2022	NON-COMPETING CONTINUATION	$0
2022	2022	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	10	2/24/2022	SUPPLEMENT FOR EXPANSION	$47,235


Issue Date FY: 2021 ( Subtotal = $2,413,372 )
2021	2021	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	9	7/22/2021	SUPPLEMENT FOR EXPANSION	$29,165
2021	2021	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	9	2/4/2021	NON-COMPETING CONTINUATION	$2,150,527
2021	2021	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	9	9/2/2021	SUPPLEMENT FOR EXPANSION	$226,970
2021	2017	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	7	8/13/2021	SUPPLEMENT FOR EXPANSION	$6,710


Issue Date FY: 2020 ( Subtotal = $2,671,138 )
2020	2020	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	8	9/10/2020	SUPPLEMENT FOR EXPANSION	$319,120
2020	2020	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	8	2/28/2020	COMPETING CONTINUATION	$2,358,728
2020	2017	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	7	11/15/2019	SUPPLEMENT FOR EXPANSION	-$6,710
2020	2016	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	7	11/15/2019	SUPPLEMENT FOR EXPANSION	$3,710
2020	2015	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	7	11/15/2019	SUPPLEMENT FOR EXPANSION	-$3,710


Issue Date FY: 2018 ( Subtotal = $0 )
2018	2015	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	7	4/20/2018	NON-COMPETING CONTINUATION	$0


Issue Date FY: 2017 ( Subtotal = $150,128 )
2017	2017	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	7	9/25/2017	SUPPLEMENT FOR EXPANSION	$150,128
2017	2015	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	7	3/31/2017	NON-COMPETING CONTINUATION	$0


Issue Date FY: 2016 ( Subtotal = $2,122,919 )
2016	2016	LOUISIANA STATE UNIV AND A&M COLLEGE	THOMAS BOYD HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	7	8/19/2016	SUPPLEMENT FOR EXPANSION	$1,822,655
2016	2016	LOUISIANA STATE UNIV AND A&M COLLEGE	THOMAS BOYD HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	7	9/27/2016	SUPPLEMENT FOR EXPANSION	$290,264
2016	2016	LOUISIANA STATE UNIV AND A&M COLLEGE	THOMAS BOYD HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	7	3/29/2016	SUPPLEMENT FOR EXPANSION	$10,000


Issue Date FY: 2015 ( Subtotal = $2,268,714 )
2015	2015	LOUISIANA STATE UNIV AND A&M COLLEGE	THOMAS BOYD HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	7	4/3/2015	NON-COMPETING CONTINUATION	$2,176,954
2015	2015	LOUISIANA STATE UNIV AND A&M COLLEGE	THOMAS BOYD HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	7	9/18/2015	SUPPLEMENT FOR EXPANSION	$91,760


Issue Date FY: 2014 ( Subtotal = $2,165,183 )
2014	2014	LOUISIANA STATE UNIV AND A&M COLLEGE	THOMAS BOYD HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	6	5/2/2014	SUPPLEMENT FOR EXPANSION	$10,000
2014	2014	LOUISIANA STATE UNIV AND A&M COLLEGE	THOMAS BOYD HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	6	4/1/2014	NON-COMPETING CONTINUATION	$2,155,183


Issue Date FY: 2013 ( Subtotal = $2,121,365 )
2013	2013	LOUISIANA STATE UNIV AND A&M COLLEGE	THOMAS BOYD HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	5	8/1/2013	SUPPLEMENT FOR EXPANSION	$42,374
2013	2013	LOUISIANA STATE UNIV AND A&M COLLEGE	THOMAS BOYD HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	5	5/7/2013	NON-COMPETING CONTINUATION	$1,741,564
2013	2013	LOUISIANA STATE UNIV AND A&M COLLEGE	THOMAS BOYD HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	5	6/26/2013	NON-COMPETING CONTINUATION	$337,427


Issue Date FY: 2012 ( Subtotal = $2,186,954 )
2012	2012	LOUISIANA STATE UNIV AND A&M COLLEGE	THOMAS BOYD HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	4	3/30/2012	NON-COMPETING CONTINUATION	$2,186,954


Issue Date FY: 2011 ( Subtotal = $1,500,077 )
2011	2011	LOUISIANA STATE UNIV AND A&M COLLEGE	THOMAS BOYD HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	2	8/31/2011	SUPPLEMENT FOR EXPANSION	$0
2011	2011	LOUISIANA STATE UNIV AND A&M COLLEGE	THOMAS BOYD HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	2	1/28/2011	SUPPLEMENT FOR EXPANSION	$20,000
2011	2011	LOUISIANA STATE UNIV AND A&M COLLEGE	THOMAS BOYD HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	3	9/1/2011	COMPETING CONTINUATION	$1,472,960
2011	2011	LOUISIANA STATE UNIV AND A&M COLLEGE	THOMAS BOYD HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	3	9/23/2011	COMPETING CONTINUATION	$7,117
2011	2010	LOUISIANA STATE UNIV AND A&M COLLEGE	THOMAS BOYD HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Trans-NIH Recovery Act Research Support	002	2	8/31/2011	NON-COMPETING CONTINUATION	$0


Issue Date FY: 2010 ( Subtotal = $1,800,000 ) (Continued on the next page)
Grand Total All Awards = $25,542,454

Sum of Action Amount is $25,542,454;

Grand Total = $25,542,454

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LSU Superfund Research Center - Environmentally Persistent Free Radicals

Award Number: P42ES013648

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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