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Health Effects and Geochemistry of Arsenic

Award Number: P42ES010349
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Health Effects and Geochemistry of Arsenic - Overall - Project Summary/Abstract: The contamination of water and aquifer sediments with arsenic (As) is associated with major public health and environmental mitigation issues in the United States. At present, 823 of 1739 U.S. Superfund sites list As as a major contaminant; in addition millions of U.S. residents are unduly exposed due to naturally occurring As in their household well water. This proposal includes two biomedical and two geoscience projects that seek to address critically important issues that collectively aim to reduce As exposure and toxicity in exposed human populations in the U.S. and in Bangladesh, where much information can be learned that will benefit residents of the U.S. and elsewhere. The proposal builds on the strengths of our existing longitudinal cohort study of 35,000 adults in Bangladesh by examining dose-response relationships between As exposure (in the low-mid range) from contaminated food and water with incident cases (and sub-types) of cardiovascular disease (CVD) and non-malignant lung disease, as well as diabetes mellitus (DM). In addition, we will combine and meta-analyze data from Bangladesh, Taiwan, China (Inner Mongolia) and the U.S. (AZ, CO, ND, OK, SD) to refine the dose-response relationships between As exposure and CVD. We build off our previous observations that: a) As exposure is associated with deficits in child intelligence; and b) that folate, a B vitamin, facilitates As metabolism and elimination in adults. We propose to conduct a randomized clinical trial in 8-10 year old children in Bangladesh to test the hypothesis that folate+B12 supplementation can: a) lower blood As; and b) improve cognitive abilities in children. Building on our previous geoscience research which indicates that in situ magnetite formation forms a diffuse barrier capable of long-term As retention, we propose to conduct laboratory and field research to optimize and implement this new approach at a U.S. Geological Survey research site on Cape Cod, MA and a Superfund site in Raleigh, NC. In Bangladesh, we will quantify the geographic and socio-political barriers to reducing As exposure by analyzing the vast data sets accumulated in our main study area and we will conduct a randomized controlled trial comparing ways to overcome some of them. In parallel, we will continue to examine the potential vulnerability to human perturbations of shallow and deep aquifers that are low in As. These low As aquifers are crucial for reducing exposure to our study population and the country at large. In the U.S., we will build on our proven success of partnering with state and local governments to reduce As exposure in communities that rely on As-contaminated household wells in ME, NJ and MN. We will also continue to facilitate effective communication among our SRP scientists, stakeholders and government partners via five specific strategies. Finally, we will continue to train the next generation of scientists with disciplinary and inter-disciplinary skills that will enable them to improve the health of those who reside in environments that might expose them to As and other contaminants in soil, water and food.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$10,800 )
2024	2020	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	18	10/1/2023	SUPPLEMENT FOR EXPANSION	-$10,800
														Subtotal = -$10,800

Issue Date FY: 2022 ( Subtotal = -$32,282 )
2022	2020	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	18	8/23/2022	SUPPLEMENT FOR EXPANSION	-$10,800
2022	2020	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	18	8/23/2022	SUPPLEMENT FOR EXPANSION	-$10,800
2022	2019	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	18	8/23/2022	SUPPLEMENT FOR EXPANSION	-$10,682
														Subtotal = -$32,282

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	18	6/29/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2020	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	18	10/15/2020	SUPPLEMENT FOR EXPANSION	$0
2021	2020	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	18	6/29/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2019	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	18	3/26/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $21,600 )
2020	2020	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	18	6/26/2020	SUPPLEMENT FOR EXPANSION	$10,800
2020	2020	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	18	6/25/2020	SUPPLEMENT FOR EXPANSION	$10,800
2020	2019	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	18	7/9/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $21,600

Issue Date FY: 2019 ( Subtotal = $1,734,649 )
2019	2019	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	18	9/19/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2019	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	18	9/13/2019	SUPPLEMENT FOR EXPANSION	$451,147
2019	2019	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	18	4/4/2019	NON-COMPETING CONTINUATION	$1,283,502
2019	2018	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	17	1/29/2019	NON-COMPETING CONTINUATION	$0
2019	2018	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	17	12/10/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,734,649

Issue Date FY: 2018 ( Subtotal = $1,468,584 )
2018	2018	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	17	5/7/2018	SUPPLEMENT FOR EXPANSION	$10,800
2018	2018	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	17	8/1/2018	SUPPLEMENT FOR EXPANSION	$177,572
2018	2018	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	17	3/30/2018	NON-COMPETING CONTINUATION	$1,280,212
2018	2017	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	16	3/23/2018	COMPETING CONTINUATION	$83,887
2018	2016	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	15	3/23/2018	SUPPLEMENT FOR EXPANSION	-$83,887
														Subtotal = $1,468,584

Issue Date FY: 2017 ( Subtotal = $1,424,943 )
2017	2017	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	16	8/4/2017	SUPPLEMENT FOR EXPANSION	$10,800
2017	2017	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	16	8/3/2017	COMPETING CONTINUATION	$1,414,143
2017	2016	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	15	1/23/2017	EXTENSION WITH OR WITHOUT FUNDS	$2,956,370
2017	2016	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	15	1/23/2017	EXTENSION WITH OR WITHOUT FUNDS	-$2,956,370
2017	2016	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	15	7/31/2017	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $1,424,943

Issue Date FY: 2016 ( Subtotal = $3,064,874 )
2016	2016	COLUMBIA UNIVERSITY, SCHOOL OF ARTS & SCIENCES	106 LOW LIBRARY	NEW YORK-NEW YORK	NY	10027		USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	15	6/24/2016	SUPPLEMENT FOR EXPANSION	$10,800
2016	2016	COLUMBIA UNIVERSITY, SCHOOL OF ARTS & SCIENCES	106 LOW LIBRARY	NEW YORK-NEW YORK	NY	10027		USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	15	9/28/2016	EXTENSION WITH OR WITHOUT FUNDS	$0
2016	2016	COLUMBIA UNIVERSITY, SCHOOL OF ARTS & SCIENCES	106 LOW LIBRARY	NEW YORK-NEW YORK	NY	10027		USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	15	9/26/2016	SUPPLEMENT FOR EXPANSION	$97,704
2016	2016	COLUMBIA UNIVERSITY, SCHOOL OF ARTS & SCIENCES	106 LOW LIBRARY	NEW YORK-NEW YORK	NY	10027		USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	15	3/28/2016	EXTENSION WITH OR WITHOUT FUNDS	$2,956,370
														Subtotal = $3,064,874

Issue Date FY: 2015 ( Subtotal = $3,042,333 )
2015	2015	COLUMBIA UNIVERSITY, SCHOOL OF ARTS & SCIENCES	106 LOW LIBRARY	NEW YORK-NEW YORK	NY	10027		USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	14	4/17/2015	NON-COMPETING CONTINUATION	$3,042,333
														Subtotal = $3,042,333

Issue Date FY: 2014 ( Subtotal = $2,988,361 )
2014	2014	COLUMBIA UNIVERSITY, SCHOOL OF ARTS & SCIENCES	106 LOW LIBRARY	NEW YORK-NEW YORK	NY	10027		USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	13	4/18/2014	NON-COMPETING CONTINUATION	$2,988,361
														Subtotal = $2,988,361

Issue Date FY: 2013 ( Subtotal = $3,019,684 )
2013	2013	COLUMBIA UNIVERSITY, SCHOOL OF ARTS & SCIENCES	106 LOW Memorial LIBRARY	NEW YORK-NEW YORK	NY	10027		USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	12	5/7/2013	NON-COMPETING CONTINUATION	$2,382,648
2013	2013	COLUMBIA UNIVERSITY, SCHOOL OF ARTS & SCIENCES	106 LOW Memorial LIBRARY	NEW YORK-NEW YORK	NY	10027		USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	12	8/1/2013	SUPPLEMENT FOR EXPANSION	$101,677
2013	2013	COLUMBIA UNIVERSITY, SCHOOL OF ARTS & SCIENCES	106 LOW Memorial LIBRARY	NEW YORK-NEW YORK	NY	10027		USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	12	6/26/2013	NON-COMPETING CONTINUATION	$461,636
2013	2013	COLUMBIA UNIVERSITY, SCHOOL OF ARTS & SCIENCES	106 LOW Memorial LIBRARY	NEW YORK-NEW YORK	NY	10027		USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	12	8/20/2013	SUPPLEMENT FOR EXPANSION	$16,332
2013	2013	COLUMBIA UNIVERSITY, SCHOOL OF ARTS & SCIENCES	106 LOW Memorial LIBRARY	NEW YORK-NEW YORK	NY	10027		USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	12	8/20/2013	SUPPLEMENT FOR EXPANSION	$57,391
														Subtotal = $3,019,684

Issue Date FY: 2012 ( Subtotal = $3,248,981 ) (Continued on the next page)
2012	2012	COLUMBIA UNIVERSITY, SCHOOL OF ARTS & SCIENCES	106 LOW Memorial LIBRARY	NEW YORK-NEW YORK	NY	10027		USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	11	4/20/2012	COMPETING CONTINUATION	$3,078,052
Grand Total All Awards = $53,603,433

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Health Effects and Geochemistry of Arsenic

Award Number: P42ES010349

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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