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Nutrition and Superfund Chemical Toxicity

Award Number: P42ES007380
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/07/1997
PERIOD OF PERFORMANCE END DATE: 01/31/2025

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Nutrition and Superfund Chemical Toxicity - PROJECT SUMMARY The University of Kentucky Superfund Research Center (UK-SRC) provides a focused, cross-disciplinary research and training environment to address critical human health challenges associated with halogenated organic substance exposures. Four center projects and five cores make up the proposed UK-SRC to further develop research on lifestyle changes (e.g., nutrition and exercise) in addition to two environmental science projects that will focus on the remediation and engineering solutions to this set of problems. Due to their relative chemical stability and ubiquity in the environment, chlorinated organic contaminants such as polychlorinated biphenyls (PCBs) and trichloroethylene (TCE) pose significant health risks and enduring remediation challenges, including sites such as the Paducah Gaseous Diffusion Plant, the largest Superfund site in Kentucky. The UK-SRC’s overall focus for this next cycle is the human health impacts of persistent halogenated organics (e.g., PCBs, TCE, and tetrachloroethene (PCE), and in this new cycle of funding, additional questions about per- and polyfluoralkyl substances (PFAS) will be incorporated. Projects covering biomedical research hypothesize that healthy nutrition and exercise components provide a platform to develop primary prevention strategies for diseases associated with environmental toxic insults, while also providing the basis for new risk assessment paradigms. Further, novel iron-based, nano-structured sensing, capture and remediation systems based on biomimetic binding domains and functionalized membrane platforms offer potential for sustainable advances in technical capability for site remediation. The UK-SRC proposes the following goals: 1) to expedite data-driven discovery as facilitated by the Data Management and Analysis Core that will provide insight about biomarkers of exposures to generate new information about the relationship between pollutant exposure, nutrient intake, physical activity and disease risk; 2) to better understand the biochemical, molecular, and cellular mechanisms underlying the toxicity of halogenated organic compounds (i.e., PCBs and PFAS) with a specific focus on chronic inflammatory diseases and windows of susceptibility; 3) to foster informed decisions that expedite clean-up of halogenated organic compounds through advanced material-based technologies, smart filters, and fate and transport science to reduce exposure risks; 4) to promote and interdisciplinary approaches to environmental health science training that accelerate the impact of complex solution-oriented, stakeholder-engaged research aimed at reducing exposures and improving human health; and 5) to engage bi-directionally and provide environmental health programmatic activities to vulnerable, socially-isolated, under-resourced communities in Kentucky, especially Eastern Kentucky (i.e. Central Appalachia), where chronic inflammatory diseases exceed national averages and exposure risks to environmental pollutants are prevalent. Activities will involve community engaged research and an innovative means of integrating projects through the WHY-ENVIRONMENT initiative.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$257,966 )
2025	2024	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE	LEXINGTON	KY	40526	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	26	6/17/2025	NON-COMPETING CONTINUATION	-$257,966
														Subtotal = -$257,966

Issue Date FY: 2024 ( Subtotal = $1,428,120 )
2024	2024	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE	LEXINGTON	KY	40526	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	26	9/12/2024	NON-COMPETING CONTINUATION	$52,910
2024	2024	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE	LEXINGTON	KY	40526	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	26	1/25/2024	NON-COMPETING CONTINUATION	$1,375,210
2024	2023	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE	LEXINGTON	KY	40526	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	25	11/16/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,428,120

Issue Date FY: 2023 ( Subtotal = $1,389,710 )
2023	2023	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	25	6/10/2023	SUPPLEMENT FOR EXPANSION	$14,500
2023	2023	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	25	1/23/2023	NON-COMPETING CONTINUATION	$1,375,210
2023	2022	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	24	10/31/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,389,710

Issue Date FY: 2022 ( Subtotal = $1,389,710 )
2022	2022	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	24	8/9/2022	SUPPLEMENT FOR EXPANSION	$14,500
2022	2022	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	24	3/23/2022	NON-COMPETING CONTINUATION	$1,375,210
2022	2022	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	24	9/8/2022	NON-COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	23	10/21/2021	NON-COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	23	11/18/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,389,710

Issue Date FY: 2021 ( Subtotal = $1,681,491 )
2021	2021	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	23	7/22/2021	SUPPLEMENT FOR EXPANSION	$13,620
2021	2021	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	006	23	9/24/2021	NON-COMPETING CONTINUATION	$0
2021	2021	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	005	23	7/23/2021	SUPPLEMENT FOR EXPANSION	$15,300
2021	2021	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	23	2/4/2021	SUPPLEMENT FOR EXPANSION	$277,361
2021	2021	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	23	1/28/2021	NON-COMPETING CONTINUATION	$1,375,210
2021	2020	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	22	7/17/2021	COMPETING CONTINUATION	$722,430
2021	2019	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	21	7/17/2021	SUPPLEMENT FOR EXPANSION	-$722,430
														Subtotal = $1,681,491

Issue Date FY: 2020 ( Subtotal = $1,783,831 )
2020	2020	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	22	9/16/2020	SUPPLEMENT FOR EXPANSION	$198,849
2020	2020	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	22	3/26/2020	COMPETING CONTINUATION	$1,584,982
2020	2020	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	22	7/14/2020	COMPETING CONTINUATION	$0
2020	2020	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	22	7/27/2020	COMPETING CONTINUATION	$0
														Subtotal = $1,783,831

Issue Date FY: 2019 ( Subtotal = $2,722,692 )
2019	2019	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	21	9/19/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2019	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	21	5/17/2019	SUPPLEMENT FOR EXPANSION	$2,441,545
2019	2019	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	21	9/12/2019	SUPPLEMENT FOR EXPANSION	$281,147
2019	2018	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	21	11/12/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,722,692

Issue Date FY: 2018 ( Subtotal = $2,498,181 )
2018	2018	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	21	5/31/2018	SUPPLEMENT FOR EXPANSION	$10,000
2018	2018	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	21	5/7/2018	SUPPLEMENT FOR EXPANSION	$10,800
2018	2018	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	21	9/10/2018	SUPPLEMENT FOR EXPANSION	$35,000
2018	2018	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	21	3/23/2018	NON-COMPETING CONTINUATION	$2,442,381
														Subtotal = $2,498,181

Issue Date FY: 2017 ( Subtotal = $2,393,534 )
2017	2017	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	20	3/24/2017	NON-COMPETING CONTINUATION	$2,198,143
2017	2017	UNIVERSITY OF KENTUCKY	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	20	6/23/2017	NON-COMPETING CONTINUATION	$195,391
														Subtotal = $2,393,534

Issue Date FY: 2016 ( Subtotal = $2,448,757 )
2016	2016	UNIVERSITY OF KENTUCKY, RESEARCH FOUNDATION	105 KINKEAD HALL	LEXINGTON	KY	40506	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	19	6/21/2016	SUPPLEMENT FOR EXPANSION	$10,800
2016	2016	UNIVERSITY OF KENTUCKY, RESEARCH FOUNDATION	105 KINKEAD HALL	LEXINGTON	KY	40506	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	19	4/6/2016	NON-COMPETING CONTINUATION	$2,417,957
2016	2016	UNIVERSITY OF KENTUCKY, RESEARCH FOUNDATION	105 KINKEAD HALL	LEXINGTON	KY	40506	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	19	6/14/2016	SUPPLEMENT FOR EXPANSION	$20,000
														Subtotal = $2,448,757

Issue Date FY: 2015 ( Subtotal = $2,447,381 )
2015	2015	UNIVERSITY OF KENTUCKY, RESEARCH FOUNDATION	105 KINKEAD HALL	LEXINGTON	KY	40506	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	17	1/26/2015	SUPPLEMENT FOR EXPANSION	$5,000
2015	2015	UNIVERSITY OF KENTUCKY, RESEARCH FOUNDATION	105 KINKEAD HALL	LEXINGTON	KY	40506	FAYETTE	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	18	4/3/2015	NON-COMPETING CONTINUATION	$2,442,381
														Subtotal = $2,447,381

Issue Date FY: 2014 ( Subtotal = $2,442,381 ) (Continued on the next page)
Grand Total All Awards = $49,222,931

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Nutrition and Superfund Chemical Toxicity

Award Number: P42ES007380

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/07/1997

PERIOD OF PERFORMANCE END DATE: 01/31/2025

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